ZBTB43 - zinc finger and BTB domain containing 43 Gene

Homo sapiens

Also known as ZNF-X; ZBTB22B; ZNF297B

Gene ID: 23099 | Gene type: protein coding

About ZBTB43

Cytogenetic location: 9q33.3 Genomic coordinates (GRCh38): 9:126,804,072-126,838,210 (from NCBI)

This gene has 5 transcripts (splice variants), 161 orthologues and 4 paralogues. Broad expression in bone marrow (RPKM 18.2), testis (RPKM 10.2) and 24 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB43 Products(2)

mRNA	Protein	Name
NM_001135776.2	NP_001129248.1	zinc finger and BTB domain-containing protein 43
NM_014007.4	NP_054726.1	zinc finger and BTB domain-containing protein 43

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase III general transcription initiation factor binding	IPI IPI: Inferred from physical interaction	16542149	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB43 Protein Structure

BTB

zf-C2H2_4

zf-H2C2_2

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

zinc finger and BTB domain-containing protein 43

zinc finger and BTB domain-containing protein 22B

ZBTB43 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZBTB43	O43298	ZNF250	Homo sapiens	P15622-3	Validated Y2H	32296183
Intra	ZBTB43	O43298	DIP2A	Homo sapiens	Q14689-6	Y2H Prey Pooling	25416956
Intra	ZBTB43	O43298	SYT6	Homo sapiens	Q5T7P8-2	Y2H Prey Pooling	25416956
Intra	ZBTB43	O43298	SYT6	Homo sapiens	Q5T7P8-2	Validated Y2H	32296183
Intra	ZBTB43	O43298	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	32296183
Intra	ZBTB43	O43298	CIB3	Homo sapiens	Q96Q77	Validated Y2H	32296183
Intra	ZBTB43	O43298	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
Intra	ZBTB43	O43298	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	ZBTB43	O43298	LMO4	Homo sapiens	P61968	Y2H Prey Pooling	25416956
Intra	ZBTB43	O43298	DDX6	Homo sapiens	P26196	Validated Y2H	32296183
Intra	ZBTB43	O43298	PSMD3	Homo sapiens	O43242	Validated Y2H	25416956
Intra	ZBTB43	O43298	PSMD3	Homo sapiens	O43242	Y2H Array	25416956
Intra	ZBTB43	O43298	CDKL3	Homo sapiens	Q8IVW4	Validated Y2H	32296183
Intra	ZBTB43	O43298	MORF4L2	Homo sapiens	Q15014	Y2H Array	25416956
Intra	ZBTB43	O43298	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	25416956
Intra	ZBTB43	O43298	AP1M1	Homo sapiens	Q9BXS5	Validated Y2H	32296183
Intra	ZBTB43	O43298	AP1M1	Homo sapiens	Q9BXS5	Y2H Prey Pooling	25416956
Intra	ZBTB43	O43298	ZNF587	Homo sapiens	Q96SQ5	Validated Y2H	32296183
Intra	ZBTB43	O43298	TCEA2	Homo sapiens	Q15560	Validated Y2H	32296183
Intra	ZBTB43	O43298	ARR3	Homo sapiens	P36575	Validated Y2H	25416956
Intra	ZBTB43	O43298	FAM161A	Homo sapiens	Q3B820	Y2H Array	25416956
Intra	ZBTB43	O43298	FAM161A	Homo sapiens	Q3B820	Validated Y2H	25416956
Intra	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Y2H Array	29892012
Intra	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
Intra	ZBTB43	O43298	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	ZBTB43	O43298	ZNF417	Homo sapiens	Q8TAU3	Y2H Pooling	16189514
Intra	ZBTB43	O43298	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	ZBTB43	O43298	ARRB1	Homo sapiens	P49407	Validated Y2H	32296183
Intra	ZBTB43	O43298	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
Intra	ZBTB43	O43298	ZBTB24	Homo sapiens	O43167	Y2H Prey Pooling	25416956
Intra	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Y2H Prey Pooling	25416956
Intra	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Validated Y2H	25416956
Intra	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	ZBTB43	O43298	LMO1	Homo sapiens	P25800	Y2H Array	25416956
Intra	ZBTB43	O43298	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	ZBTB43	O43298	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	ZBTB43	O43298	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Diamond-Blackfan Anemia 4

DBA4	Rps17-Related Diamond-Blackfan Anemia
Anemia, Diamond-Blackfan, Type 4

Spastic Paraplegia 16, X-Linked

SPG16	Hereditary Spastic Paraplegia 16
X-Linked Spastic Paraplegia Type 16	Spastic Paraplegia 16, X-Linked, Complicated
X-Linked Spastic Paraplegia 16	Spastic Paraplegia 16
Spastic Paraplegia-16, X-Linked, Complicated

Spastic Paraplegia 12, Autosomal Dominant

SPG12	Hereditary Spastic Paraplegia 12
Autosomal Dominant Spastic Paraplegia Type 12	Autosomal Dominant Spastic Paraplegia 12
Spastic Paraplegia 12	Spastic Paraplegia-12
Paraplegia, Spastic, Autosomal Dominant, Type 12

Hemochromatosis Type 2

Juvenile Hemochromatosis	Juvenile Hereditary Hemochromatosis
Hfe2	Jhh
Hemochromatosis Juvenile	Iron Overload Disease Juvenile
Hemochromatosis, Juvenile	Hemochromatosis, Type 2
Hemochromatosis	Hemochromatosis, Type 1

Hereditary Spastic Paraplegia 56

Autosomal Recessive Spastic Paraplegia Type 56	Spg56
Autosomal Recessive Spastic Paraplegia 56

Masa Syndrome

L1 Syndrome	Crash Syndrome
X-Linked Hydrocephalus Syndrome	SPG1
Gareis-Mason Syndrome	Spastic Paraplegia 1, X-Linked
Corpus Callosum Hypoplasia-Retardation-Adducted Thumbs-Spasticity-Hydrocephalus Syndrome	L1cam Syndrome
Spastic Paraplegia 1	Mental Retardation, Aphasia, Shuffling Gait, And Adducted Thumbs
Clasped Thumb And Mental Retardation	Thumb, Congenital Clasped, With Mental Retardation
Adducted Thumb With Mental Retardation	Hereditary Spastic Paraplegia 1
X-Linked Complicated Hereditary Spastic Paraplegia Type 1	X-Linked Corpus Callosum Agenesis
X-Linked Spastic Paraplegia 1	L1 Disease
X-Linked Intellectual Disability - Corpus Callosum Agenesis - Spastic Quadriparesis	Adducted Thumb With Intellectual Disability
Clasped Thumb And Intellectual Disability	Intellectual Disability Aphasia Shuffling Gait Adducted Thumbs
Thumb Congenital Clasped With Intellectual Disability	X-Linked Intellectual Disability-Corpus Callosum Agenesis-Spastic Quadriparesis Syndrome
Adducted Thumbs-Mental Retardation Syndrome	Corpus Callosum Hypoplasia, Mental Retardation, Adducted Thumbs, Spastic Paraplegia, Hydrocephalus Syndrome
Mental Retardation-Clasped Thumb Syndrome	Intellectual Disability-Aphasia-Shuffling Gait-Adducted Thumbs Syndrome
Spastic Paraplegia Type 1, X-Linked	MASA
Corpus Callosum Hypoplasia-Psychomotor Retardation, Adducted Thumbs-Spastic Paraparesis-Hydrocephalus	Crash
Masa Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15976	ZBTB43 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZBTB43	VGNC	VGNC:37082
Mus musculus	ZBTB43	MGD	MGI:1919084
Rattus norvegicus	ZBTB43	RGD	RGD:1310287
Felis catus	ZBTB43	VGNC	VGNC:67171
Macaca mulatta	ZBTB43	VGNC	VGNC:79101

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