2. Gene
  3. CLNS1A - chloride nucleotide-sensitive channel 1A Gene

CLNS1A - chloride nucleotide-sensitive channel 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as CLCI; ICln; CLNS1B

Gene ID: 1207 | Gene type: protein coding

About CLNS1A

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:77,614,530-77,637,794 (from NCBI)

This gene has 12 transcripts (splice variants) and 239 orthologues. Ubiquitous expression in adrenal (RPKM 36.6), brain (RPKM 32.8) and 25 other tissues.

Summary

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

CLNS1A Products(5)

mRNA Protein Name
NM_001293.3 NP_001284.1 methylosome subunit pICln isoform a
NM_001311199.2 NP_001298128.1 methylosome subunit pICln isoform a
NM_001311200.2 NP_001298129.1 methylosome subunit pICln isoform b
NM_001311201.2 NP_001298130.1 methylosome subunit pICln isoform c
NM_001311202.2 NP_001298131.1 methylosome subunit pICln isoform d
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11756452 GOA
Biological Process GO Annotation Evidence Reference Source
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
18984161 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
18984161 GOA
part of methylosome IDA
IDA: Inferred from direct assay
11756452 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21081503 GOA
part of pICln-Sm protein complex IDA
IDA: Inferred from direct assay
18984161 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLNS1A Protein Structure

Voldacs

Voldacs: Regulator of volume decrease after cellular swelling (35 - 160)

  • 0
  • 100
  • 200
  • 237 a.a.
Protein Preferred Names Protein Names

methylosome subunit pICln

chloride channel regulatory protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02827 CLNS1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CLNS1A VGNC VGNC:82000
Macaca mulatta CLNS1A VGNC VGNC:71261
Bos taurus CLNS1A VGNC VGNC:27455
Mus musculus CLNS1A MGD MGI:109638
Rattus norvegicus CLNS1A RGD RGD:61884