CLNS1A - chloride nucleotide-sensitive channel 1A Gene

Homo sapiens

Also known as CLCI; ICln; CLNS1B

Gene ID: 1207 | Gene type: protein coding

About CLNS1A

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:77,614,530-77,637,794 (from NCBI)

This gene has 12 transcripts (splice variants) and 239 orthologues. Ubiquitous expression in adrenal (RPKM 36.6), brain (RPKM 32.8) and 25 other tissues.

Summary

This gene encodes a protein that functions in multiple regulatory pathways. The encoded protein complexes with numerous cytosolic proteins and performs diverse functions including regulation of small nuclear ribonucleoprotein biosynthesis, platelet activation and cytoskeletal organization. The protein is also found associated with the plasma membrane where it functions as a chloride current regulator. Pseudogenes of this gene are found on chromosomes 1, 4 and 6. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]

CLNS1A Products(5)

mRNA	Protein	Name
NM_001293.3	NP_001284.1	methylosome subunit pICln isoform a
NM_001311199.2	NP_001298128.1	methylosome subunit pICln isoform a
NM_001311200.2	NP_001298129.1	methylosome subunit pICln isoform b
NM_001311201.2	NP_001298130.1	methylosome subunit pICln isoform c
NM_001311202.2	NP_001298131.1	methylosome subunit pICln isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11756452	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of methylosome	IDA IDA: Inferred from direct assay	11756452	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21081503	GOA
part of pICln-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLNS1A Protein Structure

Voldacs

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

methylosome subunit pICln

chloride channel regulatory protein

CLNS1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CLNS1A	P54105	EPB41	Homo sapiens	P11171-2	Validated Y2H	25416956
Intra	CLNS1A	P54105	EPB41	Homo sapiens	P11171-2	Y2H Array	25416956
Intra	CLNS1A	P54105	FRMD7	Homo sapiens	Q6ZUT3	Validated Y2H	32296183
Intra	CLNS1A	P54105	SNRPD2	Homo sapiens	P62316	GMS	18984161
Intra	CLNS1A	P54105	SNRPD2	Homo sapiens	P62316	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	SNRPD2	Homo sapiens	P62316	Y2H Array	25416956
Intra	CLNS1A	P54105	SNRPD2	Homo sapiens	P62316	Anti Bait CoIP	18984161
Intra	CLNS1A	P54105	SNRPD2	Homo sapiens	P62316	Validated Y2H	25416956
Intra	CLNS1A	P54105	SNRPD2	Homo sapiens	P62316	Validated Y2H	32296183
Intra	CLNS1A	P54105	LSM2	Homo sapiens	Q9Y333	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	LSM2	Homo sapiens	Q9Y333	Validated Y2H	32296183
Intra	CLNS1A	P54105	LSM3	Homo sapiens	P62310	Validated Y2H	25416956
Intra	CLNS1A	P54105	LSM3	Homo sapiens	P62310	Validated Y2H	32296183
Intra	CLNS1A	P54105	PRMT5	Homo sapiens	O14744	Anti Bait CoIP	11756452
Intra	CLNS1A	P54105	PRMT5	Homo sapiens	O14744	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	PRMT5	Homo sapiens	O14744	Pull Down	11756452
Intra	CLNS1A	P54105	PRMT5	Homo sapiens	O14744	Anti Bait CoIP	18984161
Intra	CLNS1A	P54105	PRMT5	Homo sapiens	O14744	Y2H	22365833
Intra	CLNS1A	P54105	SNRPF	Homo sapiens	P62306	GMS	18984161
Intra	CLNS1A	P54105	SNRPF	Homo sapiens	P62306	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	SNRPF	Homo sapiens	P62306	Y2H	22365833
Intra	CLNS1A	P54105	SNRPF	Homo sapiens	P62306	Anti Bait CoIP	18984161
Intra	CLNS1A	P54105	SNRPD1	Homo sapiens	P62314	Y2H	22365833
Intra	CLNS1A	P54105	SNRPD1	Homo sapiens	P62314	Validated Y2H	32296183
Intra	CLNS1A	P54105	SNRPD1	Homo sapiens	P62314	Y2H Array	25416956
Intra	CLNS1A	P54105	SNRPD1	Homo sapiens	P62314	Anti Bait CoIP	18984161
Intra	CLNS1A	P54105	SNRPD1	Homo sapiens	P62314	GMS	18984161
Intra	CLNS1A	P54105	SNRPD1	Homo sapiens	P62314	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	SNRPD1	Homo sapiens	P62314	Y2H Prey Pooling	25416956
Intra	CLNS1A	P54105	SNRPB	Homo sapiens	P14678	Anti Bait CoIP	18984161
Intra	CLNS1A	P54105	SNRPB	Homo sapiens	P14678	Y2H	22365833
Intra	CLNS1A	P54105	SNRPB	Homo sapiens	P14678	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	SNRPB	Homo sapiens	P14678	GMS	18984161
Intra	CLNS1A	P54105	SNRPD3	Homo sapiens	P62318	Y2H	22365833
Intra	CLNS1A	P54105	SNRPD3	Homo sapiens	P62318	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	SNRPD3	Homo sapiens	P62318	GMS	18984161
Intra	CLNS1A	P54105	SNRPD3	Homo sapiens	P62318	Anti Bait CoIP	18984161
Intra	CLNS1A	P54105	SNRPD3	Homo sapiens	P62318	Validated Y2H	32296183
Intra	CLNS1A	P54105	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	25416956
Intra	CLNS1A	P54105	LSM6	Homo sapiens	P62312	Validated Y2H	25416956
Intra	CLNS1A	P54105	LSM6	Homo sapiens	P62312	Validated Y2H	32296183
Intra	CLNS1A	P54105	LSM6	Homo sapiens	P62312	Anti Tag CoIP	35271311
Intra	CLNS1A	P54105	SNRPG	Homo sapiens	P62308	GMS	18984161
Intra	CLNS1A	P54105	SNRPG	Homo sapiens	P62308	Anti Bait CoIP	18984161
Intra	CLNS1A	P54105	SNRPG	Homo sapiens	P62308	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02827	CLNS1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CLNS1A	VGNC	VGNC:82000
Macaca mulatta	CLNS1A	VGNC	VGNC:71261
Bos taurus	CLNS1A	VGNC	VGNC:27455
Mus musculus	CLNS1A	MGD	MGI:109638
Rattus norvegicus	CLNS1A	RGD	RGD:61884

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