SNRPB - small nuclear ribonucleoprotein polypeptides B and B1 Gene

Homo sapiens

Also known as COD; CCMS; SNRPB1; SmB/B'; Sm-B/B'; snRNP-B; SmB/SmB'

Gene ID: 6628 | Gene type: protein coding

About SNRPB

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:2,461,642-2,470,789 (from NCBI)

This gene has 10 transcripts (splice variants), 228 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 101.8), lymph node (RPKM 67.1) and 25 other tissues.

Summary

The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]

SNRPB Products(2)

mRNA	Protein	Name
NM_003091.4	NP_003082.1	small nuclear ribonucleoprotein-associated proteins B and B' isoform B
NM_198216.2	NP_937859.1	small nuclear ribonucleoprotein-associated proteins B and B' isoform B'

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8076607	GOA
enables telomerase RNA binding	IPI IPI: Inferred from physical interaction	18082603	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
acts upstream of or within protein methylation	IDA IDA: Inferred from direct assay	18495660	GOA
involved in spliceosomal snRNP assembly	IDA IDA: Inferred from direct assay	18984161	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SMN-Sm protein complex	IDA IDA: Inferred from direct assay	18984161	GOA
part of U1 snRNP	IDA IDA: Inferred from direct assay	21113136	GOA
part of U1 snRNP	IPI IPI: Inferred from physical interaction	33677607	GOA
part of U12-type spliceosomal complex	IDA IDA: Inferred from direct assay	15146077	GOA
part of U2-type catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	28076346	GOA
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
part of U2-type spliceosomal complex	IDA IDA: Inferred from direct assay	32494006	GOA
part of U4 snRNP	IDA IDA: Inferred from direct assay	21516107	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: Inferred from direct assay	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: Inferred from physical interaction	30975767	GOA
part of U7 snRNP	IDA IDA: Inferred from direct assay	11574479	GOA
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18984161	GOA
part of methylosome	IDA IDA: Inferred from direct assay	18984161	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28076346	GOA
part of spliceosomal complex	IPI IPI: Inferred from physical interaction	33677607	GOA
part of telomerase holoenzyme complex	IDA IDA: Inferred from direct assay	18082603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPB Protein Structure

LSM

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

small nuclear ribonucleoprotein-associated proteins B and B'

B polypeptide of Sm protein

SNRPB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SNRPB	P14678	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	SF3A2	Homo sapiens	Q15428	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Anti Bait CoIP	37248947
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	X-Ray Diffraction	19325628
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Ion Exchange Chrom	19325628
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	SNRPD3	Homo sapiens	P62318	Comig Non-Denat Gel	18984161
Intra	SNRPB	P14678	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	CLNS1A	Homo sapiens	P54105	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	STRAP	Homo sapiens	Q9Y3F4	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	STRAP	Homo sapiens	Q9Y3F4	Pull Down	15848170
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Y2H	16000308
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	NMR	16000308
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Anti Tag CoIP	35271311
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Y2H Array	31515488
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Anti Tag CoIP	33961781
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Peptide Array	15105431
Intra	SNRPB	P14678	CD2BP2	Homo sapiens	O95400	Confocal	15105431
Intra	SNRPB	P14678	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	SNRPB	P14678	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	SNRPB	P14678	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	SNRPB	P14678	COIL	Homo sapiens	P38432	Pull Down	21070772
Intra	SNRPB	P14678	COIL	Homo sapiens	P38432	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Rare Disease With Pierre Robin Syndrome

Pierre Robin Syndrome

Pierre Robin Sequence	Glossoptosis, Micrognathia, And Cleft Palate
Pierre Robin Syndrome Skeletal Dysplasia Polydactyly	Pierre-Robin Syndrome
Isolated Pierre Robin Sequence	Isolated Pierre-Robin Syndrome
PRBNS	Robin Sequence
Robin Syndrome	Isolated Pierre Robin Syndrome

Lupus Erythematosus

Lupus	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus, Systemic
Subacute Cutaneous Lupus	Le - [Lupus Erythematosus]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Burn-Mckeown Syndrome

Choanal Atresia-Hearing Loss-Cardiac Defects-Craniofacial Dysmorphism Syndrome	Oculootofacial Dysplasia
BMKS	Oofd
Bilateral Choanal Atresia, Cardiac Defects, Deafness, And Dysmorphic Appearance	Choanal Atresia - Deafness - Cardiac Defects - Dysmorphism Syndrome
Choanal Atresia Deafness Cardiac Defects Dysmorphism	Oculo-Oto-Facial Dysplasia

Mandibulofacial Dysostosis, Guion-Almeida Type

Mandibulofacial Dysostosis With Microcephaly	Mandibulofacial Dysostosis-Microcephaly Syndrome
MFDGA	MFDM
Mfdm Syndrome	Growth And Mental Retardation, Mandibulofacial Dysostosis, Microcephaly, And Cleft Palate
Growth Delay - Intellectual Disability - Mandibulofacial Dysostosis - Microcephaly - Cleft Palate	Growth Delay-Intellectual Disability-Mandibulofacial Dysostosis-Microcephaly-Cleft Palate Syndrome
Dysostosis, Mandibulofacial, Guion-Almeida Type

Acrofacial Dysostosis 1, Nager Type

Nager Syndrome	Nager Acrofacial Dysostosis
AFD1	Preaxial Acrofacial Dysostosis
Mandibulofacial Dysostosis, Treacher Collins Type, With Limb Anomalies	Afd, Nager Type
Nager Acrofacial Dysostosis Syndrome	Nafd
Acrofacial Dysostosis, Nager Type	Afd
Preaxial Manibulofacial Dysostosis	Split Hand Deformity-Mandibulofacial Dysostosis
Preaxial Mandibulofacial Dysostosis	Mandibulofacial Dysostosis With Preaxial Limb Anomalies
Preaxial Acrodysostosis	Afd Nager Type
Mandibulofacial Dysostosis Treacher Collins Type With Limb Anomalies

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Microcephaly, Autosomal Dominant

Autosomal Dominant Microcephaly	Microcephaly Autosomal Dominant
Autosomal Dominant Primary Microcephaly	Microcephaly With Autosomal Dominant Inheritance

Acrofacial Dysostosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13502	SNRPB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13503	SNRPB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SNRPB	VGNC	VGNC:99671
Macaca mulatta	SNRPB	VGNC	VGNC:77676
Bos taurus	SNRPB	VGNC	VGNC:35076
Rattus norvegicus	SNRPB	RGD	RGD:621301
Mus musculus	SNRPB	MGD	MGI:98342

Name
Email *

	Sorry, but the email address you supplied was invalid.