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  2. SNRPD2 - small nuclear ribonucleoprotein D2 polypeptide Gene

SNRPD2 - small nuclear ribonucleoprotein D2 polypeptide Gene

Homo sapiens

Also known as SMD2; Sm-D2; SNRPD1

Gene ID: 6633 | Gene type: protein coding

About SNRPD2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,687,454-45,692,316 (from NCBI)

This gene has 8 transcripts (splice variants) and 263 orthologues. Ubiquitous expression in ovary (RPKM 85.9), lymph node (RPKM 73.9) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the small nuclear ribonucleoprotein core protein family. It is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

SNRPD2 Products(5)

mRNA Protein Name
NM_001369751.1 NP_001356680.1 small nuclear ribonucleoprotein Sm D2 isoform 2
NM_001369752.1 NP_001356681.1 small nuclear ribonucleoprotein Sm D2 isoform 3
NM_001384647.1 NP_001371576.1 small nuclear ribonucleoprotein Sm D2 isoform 1
NM_004597.6 NP_004588.1 small nuclear ribonucleoprotein Sm D2 isoform 1
NM_177542.3 NP_808210.2 small nuclear ribonucleoprotein Sm D2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9417867 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
18984161 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SMN-Sm protein complex IDA
IDA: Inferred from direct assay
18984161 GOA
part of U1 snRNP IDA
IDA: Inferred from direct assay
21113136 GOA
part of U1 snRNP IPI
IPI: Inferred from physical interaction
33677607 GOA
part of U12-type spliceosomal complex IDA
IDA: Inferred from direct assay
15146077 GOA
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of U2-type precatalytic spliceosome IDA
IDA: Inferred from direct assay
28781166 GOA
part of U2-type spliceosomal complex IDA
IDA: Inferred from direct assay
32494006 GOA
part of U4 snRNP IDA
IDA: Inferred from direct assay
21516107 GOA
part of U4/U6 x U5 tri-snRNP complex IDA
IDA: Inferred from direct assay
26912367 GOA
part of U4/U6 x U5 tri-snRNP complex IPI
IPI: Inferred from physical interaction
30975767 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18984161 GOA
part of methylosome IDA
IDA: Inferred from direct assay
18984161 GOA
located in nucleus IDA
IDA: Inferred from direct assay
28076346 GOA
part of pICln-Sm protein complex IDA
IDA: Inferred from direct assay
18984161 GOA
part of spliceosomal complex IPI
IPI: Inferred from physical interaction
33677607 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SNRPD2 Protein Structure

LSM

LSM: LSM domain (37 - 109)

  • 0
  • 100
  • 118 a.a.
Protein Preferred Names Protein Names

small nuclear ribonucleoprotein Sm D2

small nuclear ribonucleoprotein D2 polypeptide 16.5kDa

SNRPD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SNRPD2 P62316 SPANXN2 Homo sapiens Q5MJ10
Validated Y2H
32296183
Intra SNRPD2 P62316 LSM2 Homo sapiens Q9Y333
Anti Tag CoIP
35271311
Intra SNRPD2 P62316 SNRPF Homo sapiens P62306
Y2H Array
32296183
Intra SNRPD2 P62316 SNRPF Homo sapiens P62306
Anti Tag CoIP
35271311
Intra SNRPD2 P62316 SNRPF Homo sapiens P62306
Y2H Prey Pooling
32296183
Intra SNRPD2 P62316 SNRPD1 Homo sapiens P62314
Crosslink
30021884
Intra SNRPD2 P62316 SNRPD1 Homo sapiens P62314
Y2H
9417867
Intra SNRPD2 P62316 SNRPD1 Homo sapiens P62314
Anti Tag CoIP
35271311
Intra SNRPD2 P62316 LSM6 Homo sapiens P62312
Anti Tag CoIP
35271311
Intra SNRPD2 P62316 LSM6 Homo sapiens P62312
Y2H
22365833
Intra SNRPD2 P62316 CLNS1A Homo sapiens P54105
Y2H Prey Pooling
25416956
Intra SNRPD2 P62316 CLNS1A Homo sapiens P54105
Y2H Prey Pooling
32296183
Intra SNRPD2 P62316 CLNS1A Homo sapiens P54105
Y2H Array
32296183
Intra SNRPD2 P62316 CLNS1A Homo sapiens P54105
Anti Tag CoIP
35271311
Intra SNRPD2 P62316 CLNS1A Homo sapiens P54105
Y2H
22365833
Intra SNRPD2 P62316 STRAP Homo sapiens Q9Y3F4
Anti Tag CoIP
35271311
Intra SNRPD2 P62316 STRAP Homo sapiens Q9Y3F4
Pull Down
15848170
Intra SNRPD2 P62316 CINP Homo sapiens Q9BW66
Validated Y2H
32296183
Intra SNRPD2 P62316 GEMIN6 Homo sapiens Q8WXD5
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 2

NS2

Noonan Syndrome, Autosomal Recessive

Noonan Syndrome 2, Autosomal Recessive

Noonan Syndrome, Type 2

Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]

Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus SNRPD2 VGNC VGNC:35079
Mus musculus SNRPD2 MGD MGI:98345
Canis familiaris SNRPD2 VGNC VGNC:53987
Rattus norvegicus SNRPD2 RGD RGD:1593018