Ctla4 - cytotoxic T-lymphocyte-associated protein 4 Gene

Mus musculus

Also known as Cd152; Ly-56; Ctla-4

Gene ID: 12477 | Gene type: protein coding

About Ctla4

Chromosome 1: 60,926,159-60,954,991 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 157 orthologues, 1 paralogue and is associated with 34 phenotypes. Biased expression in thymus adult (RPKM 1.4), spleen adult (RPKM .8) and 6 other tissues.

Summary

This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

Ctla4 Products(2)

mRNA	Protein	Name
NM_001281976.1	NP_001268905.1	cytotoxic T-lymphocyte protein 4 isoform 2 precursor
NM_009843.4	NP_033973.2	cytotoxic T-lymphocyte protein 4 isoform 1 precursor

Ctla4 Protein Structure

IgV_CTLA-4

0
100
200
223 a.a.

Protein Preferred Names

Protein Names

cytotoxic T-lymphocyte protein 4

CD152 antigen

cytotoxic T-lymphocyte-associated antigen 4

Recombinant Ctla4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70706	CTLA-4 Protein, Mouse (HEK293, Fc)	P09793 (A37-D161)	≥95%
HY-P71991	CTLA-4 Protein, Mouse (HEK293, His)	P09793 (A37-D161)	≥95%
HY-P75317	CTLA-4 Protein, Mouse (Biotinylated, HEK293, His)	P09793 (E36-F162)	≥95%

Related Agents

Approval

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9901	Ipilimumab	Inhibitor	99.88%	Unkown
HY-108829	Abatacept		≥99.0%	Unkown
HY-P9918	Tremelimumab		99.50%	Unkown

Clinical Phase

Inhibitory Antibodies (10)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99117	Cadonilimab	Inhibitor	/	Phase 3
HY-P99484	Botensilimab	Inhibitor	97.18%	Phase 3
HY-P990042	Gotistobart	Inhibitor	98.00%	Phase 3
HY-P99540	Tuvonralimab	Inhibitor	99.14%	Phase 3
HY-P99166	Vudalimab	Inhibitor	≥99.0%	Phase 2
HY-P99514	Zalifrelimab	Inhibitor	98.28%	Phase 2
HY-P99809	Quavonlimab	Inhibitor	≥99.0%	Phase 2
HY-P99714	Lorigerlimab	Inhibitor	/	Phase 2
HY-P99760	Nurulimab	Inhibitor	95.00%	Phase 1
HY-P99844	Davoceticept		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03299	CTLA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03300	Ctla4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03301	Ctla4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99132	Anti-Mouse CTLA-4 Antibody (9D9)		≥98.0%	Unkown
HY-108829A	Abatacept (powder)	Inhibitor	95.00%	Unkown
HY-P990041	Firastotug	Inhibitor	/	Unkown
HY-P990048	Muzastotug	Inhibitor	/	Unkown
HY-P990703	Porustobart		/	Unkown
HY-P99354	Bavunalimab		/	Unkown
HY-P99943	Erfonrilimab		/	Unkown
HY-P990080	Sovipostobart	Inhibitor	/	Unkown
HY-P990690	Volrustomig		/	Unkown
HY-P990722	Danvilostomig		/	Unkown
HY-P990739	Evalstotug		/	Unkown
HY-P990775	Vilastobart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctla4	NCBI	NCBI:1493
Canis familiaris	Ctla4	NCBI	NCBI:403696
Macaca fascicularis	Ctla4	NCBI	NCBI:102115124
Rattus norvegicus	Ctla4	NCBI	NCBI:63835
Macaca mulatta	Ctla4	NCBI	NCBI:705673

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