CHMP1B - charged multivesicular body protein 1B Gene

Homo sapiens

Also known as Vps46B; C10orf2; C18orf2; CHMP1.5; Vps46-2; C18-ORF2; hVps46-2

Gene ID: 57132 | Gene type: protein coding

About CHMP1B

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:11,851,413-11,854,444 (from NCBI)

This gene has 2 transcripts (splice variants), 189 orthologues and 4 paralogues.

Summary

CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface Receptor Proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]

CHMP1B Products(1)

mRNA	Protein	Name
NM_020412.5	NP_065145.2	charged multivesicular body protein 1b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables MIT domain binding	IDA IDA: Inferred from direct assay	16174732	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16730941	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14505570	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17928862	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagosome maturation	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in cell division	IMP IMP: Inferred from mutant phenotype	19129479	GOA
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	23015756	GOA
involved in late endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	17984323	GOA
involved in midbody abscission	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	16554368	GOA
involved in nuclear membrane reassembly	IMP IMP: Inferred from mutant phenotype	26040713	GOA
involved in nucleus organization	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	24482116	GOA
involved in regulation of centrosome duplication	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	20616062	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA IDA: Inferred from direct assay	17984323	GOA
involved in viral budding from plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA
involved in viral budding via host ESCRT complex	IDA IDA: Inferred from direct assay	24878737	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESCRT III complex	IDA IDA: Inferred from direct assay	24878737	GOA
located in amphisome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in autophagosome membrane	IDA IDA: Inferred from direct assay	17984323	GOA
located in endosome membrane	IDA IDA: Inferred from direct assay	25556234	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	26040712	GOA
located in kinetochore microtubule	IDA IDA: Inferred from direct assay	26040712	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	17984323	GOA
part of membrane coat	IDA IDA: Inferred from direct assay	24878737	GOA
located in midbody	IDA IDA: Inferred from direct assay	26040712	GOA
located in multivesicular body membrane	IDA IDA: Inferred from direct assay	16554368	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	26040713	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24878737	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP1B Protein Structure

Snf7

0
100
199 a.a.

Protein Preferred Names

Protein Names

charged multivesicular body protein 1b

chromatin modifying protein 1B

CHMP1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CHMP1B	Q7LBR1	SNRNP200	Homo sapiens	O75643	Y2H	16730941
Intra	CHMP1B	Q7LBR1	USP8	Homo sapiens	P40818	Pull Down	17711858
Intra	CHMP1B	Q7LBR1	USP8	Homo sapiens	P40818	Anti Tag CoIP	17711858
Intra	CHMP1B	Q7LBR1	CHMP1A	Homo sapiens	Q9HD42	Anti Tag CoIP	33961781
Intra	CHMP1B	Q7LBR1	VPS4A	Homo sapiens	Q9UN37	SPR	17928862
Intra	CHMP1B	Q7LBR1	VPS4A	Homo sapiens	Q9UN37	Y2H	16730941
Intra	CHMP1B	Q7LBR1	IST1	Homo sapiens	P53990-4	SPR	19525971
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Array	25416956
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H	16730941
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Array	32296183
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Beta Lactamase	16730941
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Prey Pooling	32296183
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Pull Down	17711858
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	16730941
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H Array	31515488
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Anti Tag CoIP	17711858
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Y2H	17711858
Intra	CHMP1B	Q7LBR1	STAMBP	Homo sapiens	O95630	Confocal	16730941
Intra	CHMP1B	Q7LBR1	MITD1	Homo sapiens	Q8WV92	Validated Y2H	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Validated Y2H	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Y2H Array	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Y2H Prey Pooling	32296183
Intra	CHMP1B	Q7LBR1	VTA1	Homo sapiens	Q9NP79	Anti Tag CoIP	33961781
Intra	CHMP1B	Q7LBR1	RAB11A	Homo sapiens	P62491	Y2H	16730941
Intra	CHMP1B	Q7LBR1	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	CHMP1B	Q7LBR1	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	CHMP1B	Q7LBR1	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 8

Pontocerebellar Hypoplasia Type 8	PCH8
Pontocerebellar Hypoplasia Due To Chmp1a Mutation	Pontocerebellar Hypoplasia 8
Hypoplasia, Pontocerebellar, Type 8

Pontocerebellar Hypoplasia, Type 1a

Pontocerebellar Hypoplasia Type 1a	PCH1A
Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy	Pontocerebellar Hypoplasia With Anterior Horn Cell Disease
Pch1	Pontocerebellar Hypoplasia 1a
Hypoplasia, Pontocerebellar, Type 1a	Pontocerebellar Hypoplasia Type 1

Spastic Paraplegia 80, Autosomal Dominant

SPG80	Hereditary Spastic Paraplegia 80
Spastic Paraplegia 80 Autosomal Dominant	Doid:0112341

Spinal Cord Neuroblastoma

Neuroblastoma Of The Spinal Cord

Spinal Cord Primitive Neuroectodermal Neoplasm

Spinal Cord Pnet

Spinal Cord Primitive Neuroectodermal Tumor

Spastic Paraplegia 10, Autosomal Dominant

SPG10	Hereditary Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia Type 10	Spastic Paraplegia 10
Spastic Paraplegia 10 With Or Without Peripheral Neuropathy	Autosomal Dominant Spastic Paraplegia 10
Autosomal Dominant Spastic Paraplegia	Spastic Paraplegia, Autosomal Dominant
Paraplegia, Spastic, Autosomal Dominant, Type 10

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02639	CHMP1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHMP1B	RGD	RGD:1593500
Mus musculus	CHMP1B	MGD	MGI:1914314

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