2. Gene
  3. RIPPLY2 - ripply transcriptional repressor 2 Gene

RIPPLY2 - ripply transcriptional repressor 2 Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as SCDO6; C6orf159; dJ237I15.1

Gene ID: 134701 | Gene type: protein coding

About RIPPLY2

Summary

This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RIPPLY2 Products(1)

mRNA Protein Name
NM_001009994.3 NP_001009994.1 protein ripply2 isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein ripply2

ripply2 homolog

RIPPLY2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra RIPPLY2 Q5TAB7 TFG Homo sapiens Q05BK6
Y2H Array
25416956
Intra RIPPLY2 Q5TAB7 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra RIPPLY2 Q5TAB7 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra RIPPLY2 Q5TAB7 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra RIPPLY2 Q5TAB7 NDUFB7 Homo sapiens P17568
Y2H Prey Pooling
32296183
Intra RIPPLY2 Q5TAB7 NDUFB7 Homo sapiens P17568
Y2H Array
32296183
Intra RIPPLY2 Q5TAB7 C3orf36 Homo sapiens Q3SXR2
Y2H Array
32296183
Intra RIPPLY2 Q5TAB7 C3orf36 Homo sapiens Q3SXR2
Y2H Prey Pooling
32296183
Intra RIPPLY2 Q5TAB7 PBX2 Homo sapiens P40425
Y2H Array
32296183
Intra RIPPLY2 Q5TAB7 PBX2 Homo sapiens P40425
MAPPIT
32296183
Intra RIPPLY2 Q5TAB7 PBX2 Homo sapiens P40425
Y2H Prey Pooling
32296183
Intra RIPPLY2 Q5TAB7 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra RIPPLY2 Q5TAB7 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra RIPPLY2 Q5TAB7 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra RIPPLY2 Q5TAB7 GOLM1 Homo sapiens Q8NBJ4
Validated Y2H
32296183
Intra RIPPLY2 Q5TAB7 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
Intra RIPPLY2 Q5TAB7 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
Intra RIPPLY2 Q5TAB7 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
Intra RIPPLY2 Q5TAB7 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra RIPPLY2 Q5TAB7 KASH5 Homo sapiens Q8N6L0
Validated Y2H
27107012
Intra RIPPLY2 Q5TAB7 KASH5 Homo sapiens Q8N6L0
BFG-2H
27107012
Intra RIPPLY2 Q5TAB7 KASH5 Homo sapiens Q8N6L0
Validated Y2H
32296183
Intra RIPPLY2 Q5TAB7 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra RIPPLY2 Q5TAB7 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra RIPPLY2 Q5TAB7 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
25416956
Intra RIPPLY2 Q5TAB7 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra RIPPLY2 Q5TAB7 AVPI1 Homo sapiens Q5T686
Y2H Prey Pooling
32296183
Intra RIPPLY2 Q5TAB7 AVPI1 Homo sapiens Q5T686
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction