2. Gene
  3. NDUFB7 - NADH:ubiquinone oxidoreductase subunit B7 Gene

NDUFB7 - NADH:ubiquinone oxidoreductase subunit B7 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as B18; CI-B18; MC1DN39

Gene ID: 4713 | Gene type: protein coding

About NDUFB7

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:14,566,078-14,572,066 (from NCBI)

This gene has 2 transcripts (splice variants), 184 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 29.3), heart (RPKM 25.7) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the Enzyme is believed to be ubiquinone. [provided by RefSeq, Jul 2008]

NDUFB7 Products(1)

mRNA Protein Name
NM_004146.6 NP_004137.2 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NADH dehydrogenase (ubiquinone) activity IMP
IMP: Inferred from mutant phenotype
33502047 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitochondrial respiratory chain complex I assembly IMP
IMP: Inferred from mutant phenotype
27626371 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
28844695 GOA
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
21310150 GOA
part of respiratory chain complex I IDA
IDA: Inferred from direct assay
12611891 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFB7 Protein Structure

NDUF_B7

NDUF_B7: NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) (38 - 103)

  • 0
  • 100
  • 137 a.a.
Protein Preferred Names Protein Names

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa

NDUFB7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NDUFB7 P17568 RIPPLY1 Homo sapiens Q0D2K3
Validated Y2H
32296183
Intra
NDUFB7 P17568 RIPPLY2 Homo sapiens Q5TAB7
Validated Y2H
32296183
Intra
NDUFB7 P17568 RECK Homo sapiens Q6P9E2
Validated Y2H
32296183
Intra
NDUFB7 P17568 NFKBID Homo sapiens Q8NI38
Validated Y2H
32296183
Intra
NDUFB7 P17568 ZNF564 Homo sapiens Q8TBZ8
Validated Y2H
32296183
Intra
NDUFB7 P17568 CCDC24 Homo sapiens Q8N4L8
Validated Y2H
32296183
Intra
NDUFB7 P17568 TLE5 Homo sapiens Q08117-2
Validated Y2H
32296183
Intra
NDUFB7 P17568 KRTAP10-10 Homo sapiens P60014
Validated Y2H
32296183
Intra
NDUFB7 P17568 LMO2 Homo sapiens P25791-3
Validated Y2H
32296183
Intra
NDUFB7 P17568 GPATCH2L Homo sapiens Q9NWQ4-1
Validated Y2H
32296183
Intra
NDUFB7 P17568 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
NDUFB7 P17568 CLCNKA Homo sapiens P51800-3
Validated Y2H
32296183
Intra
NDUFB7 P17568 ATG9A Homo sapiens Q7Z3C6-3
Validated Y2H
32296183
Intra
NDUFB7 P17568 STRA6 Homo sapiens Q9BX79-6
Validated Y2H
32296183
Intra
NDUFB7 P17568 ANKRD36B Homo sapiens Q8N2N9-4
Validated Y2H
32296183
Intra
NDUFB7 P17568 AGBL2 Homo sapiens Q5U5Z8-3
Validated Y2H
32296183
Intra
NDUFB7 P17568 WUGSC:H_DJ0726N20.gs.b Homo sapiens Q9Y6T4
Validated Y2H
32296183
Intra
NDUFB7 P17568 RCOR3 Homo sapiens Q9P2K3-2
Validated Y2H
32296183
Intra
NDUFB7 P17568 RCOR3 Homo sapiens Q9P2K3-2
Y2H Array
32296183
Intra
NDUFB7 P17568 MKRN3 Homo sapiens Q13064
Validated Y2H
32296183
Intra
NDUFB7 P17568 TFAP4 Homo sapiens Q01664
Validated Y2H
32296183
Intra
NDUFB7 P17568 NFKBIB Homo sapiens Q15653
Validated Y2H
32296183
Intra
NDUFB7 P17568 ZNF330 Homo sapiens Q9Y3S2
Validated Y2H
32296183
Intra
NDUFB7 P17568 CCNC Homo sapiens P24863
Validated Y2H
32296183
Intra
NDUFB7 P17568 CDCA7L Homo sapiens Q96GN5
Validated Y2H
32296183
Intra
NDUFB7 P17568 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
NDUFB7 P17568 FAM90A1 Homo sapiens Q86YD7
Validated Y2H
32296183
Intra
NDUFB7 P17568 SPRED2 Homo sapiens Q7Z698
Validated Y2H
32296183
Intra
NDUFB7 P17568 FAM161B Homo sapiens Q96MY7
Validated Y2H
32296183
Intra
NDUFB7 P17568 CINP Homo sapiens Q9BW66
Validated Y2H
32296183
Intra
NDUFB7 P17568 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
NDUFB7 P17568 CHIC2 Homo sapiens Q9UKJ5
Validated Y2H
32296183
Intra
NDUFB7 P17568 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
NDUFB7 P17568 GEM Homo sapiens P55040
Validated Y2H
32296183
Intra
NDUFB7 P17568 CDKN2D Homo sapiens P55273
Validated Y2H
32296183
Intra
NDUFB7 P17568 MAGOHB Homo sapiens Q96A72
Validated Y2H
32296183
Intra
NDUFB7 P17568 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
NDUFB7 P17568 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mitochondrial Disorder Due To A Defect In Assembly Or Maturation Of The Respiratory Chain Complexes
Mitochondrial Complex Iii Deficiency

Complex 3 Mitochondrial Respiratory Chain Deficiency

Isolated Coq-Cytochrome C Reductase Deficiency

Ubiquinone-Cytochrome C Oxidoreductase Deficiency
Mitochondrial Complex V Deficiency, Nuclear Type 3

Mitochondrial Complex Iii Deficiency Nuclear Type 5

MC5DN3

Mitochondrial Complex Iii Deficiency, Nuclear Type 5

Mitochondrial Complex V Deficiency Nuclear Type 3

MC3DN5

Mitochondrial Complex V Deficiency, Atp5e Type

Mitochondrial Complex Iii Deficiency, Nuclear 5

Mitochondrial Complex V Deficiency, Nuclear Type 3

Mitochondrial Complex V Deficiency Atp5e Type

Mitochondrial Complex V Deficiency Type 3

Mitochondrial Complex V Deficiency, Nuclear, Type 3
Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Leigh Syndrome

Leigh Disease

Infantile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency

LS

Sne

Leigh'S Disease

Leigh Syndrome Due To Mitochondrial Complex I Deficiency

Necrotizing Encephalopathy, Infantile Subacute, Of Leigh

Subacute Necrotizing Encephalomyelopathy

Necrotizing Encephalopathy Infantile Subacute Of Leigh

Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency

Infantile Necrotizing Encephalomyelopathy

Juvenile Subacute Necrotizing Encephalomyelopathy

Leigh'S Necrotizing Encephalopathy

Subacute Necrotizing Encephalopathy

Juvenile Subacute Necrotizing Encephalopathy

Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency

Leigh Syndrome Due To Mitochondrial Complex V Deficiency

Encephalopathy, Subacute Necrotizing, Infantile

Encephalopathy, Subacute Necrotizing, Juvenile

Maternally Inherited Leigh Syndrome

Subacute Necrotising Encephalomyelopathy

Subacute Necrotising Encephalopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09152 NDUFB7 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-169281 Antiviral agent 61 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NDUFB7 VGNC VGNC:68443
Canis familiaris NDUFB7 VGNC VGNC:43705
Bos taurus NDUFB7 VGNC VGNC:31966
Mus musculus NDUFB7 MGD MGI:1914166
Rattus norvegicus NDUFB7 RGD RGD:1308550