Hgf - hepatocyte growth factor Gene

Mus musculus

Also known as SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik

Gene ID: 15234 | Gene type: protein coding

About Hgf

Summary

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Hgf Products(5)

mRNA	Protein	Name
NM_001289458.1	NP_001276387.1	hepatocyte growth factor isoform 1 preproprotein
NM_001289459.1	NP_001276388.1	hepatocyte growth factor isoform 1 preproprotein
NM_001289460.2	NP_001276389.1	hepatocyte growth factor isoform 2 precursor
NM_001289461.1	NP_001276390.1	hepatocyte growth factor isoform 3 preproprotein
NM_010427.5	NP_034557.3	hepatocyte growth factor isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17804794	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cell morphogenesis	IDA IDA: Inferred from direct assay	12130561	MGI
acts upstream of or within epithelial cell proliferation	IDA IDA: Inferred from direct assay	12130561	MGI
acts upstream of or within hepatocyte growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15314156	MGI
acts upstream of or within liver development	IDA IDA: Inferred from direct assay	16880525	MGI
acts upstream of or within myoblast proliferation	IDA IDA: Inferred from direct assay	11061428	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA IDA: Inferred from direct assay	15314156	MGI
acts upstream of or within negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	21072211	MGI
acts upstream of or within negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	21072211	MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21072211	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15314156	MGI
acts upstream of or within positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	21072211	MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	IMP IMP: Inferred from mutant phenotype	14517989	MGI
acts upstream of or within regulation of p38MAPK cascade	IDA IDA: Inferred from direct assay	23994610	MGI
acts upstream of or within regulation of tau-protein kinase activity	IDA IDA: Inferred from direct assay	21072211	MGI
acts upstream of or within skeletal muscle cell proliferation	IDA IDA: Inferred from direct assay	11061428	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte growth factor

hepatopoietin-A

scatter factor

Recombinant Hgf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70561	HGF Protein, Mouse (HEK293, His)	Q08048-1 (Q33-L728)	≥95%
HY-P73928	HGF Protein, Mouse (HEK293)	Q08048-1 (Q33-L728)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0020	Eldecalcitol		99.94%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137455	Terevalefim	Activator	99.89%	Phase 3
HY-18696	AMG-337		99.43%	Phase 2

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99250	Onartuzumab	Inhibitor	99.62%	Phase 3
HY-P99196	Ficlatuzumab	Inhibitor	99.21%	Phase 3
HY-P99217	Rilotumumab	Inhibitor	99.10%	Phase 3
HY-P99192	Emibetuzumab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16969	Dihexa	Activator	98.92%	Unkown
HY-116282D	Dextran sulfate sodium salt (MW 450000-550000)		/	Unkown
HY-114363A	SRI 31215 TFA	Inhibitor	98.53%	Unkown
HY-106961	ONO 1301	Agonist	99.06%	Unkown
HY-W014940	Ethylene glycol dimethacrylate		99.52%	Unkown
HY-P1415A	Norleual TFA		99.32%	Unkown
HY-154988	MARK4 inhibitor 4		99.23%	Unkown
HY-145263	VD2173	Inhibitor	/	Unkown
HY-N13286	Glycozolidal	Inhibitor	99.92%	Unkown
HY-10338A	Foretinib phosphate	Inhibitor	/	Unkown
HY-106961A	(Z)-ONO 1301	Agonist	/	Unkown
HY-120159	GS-493	Inhibitor	/	Unkown
HY-P1415	Norleual		/	Unkown
HY-RS06152	HGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990949	Umikibart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hgf	NCBI	NCBI:3082
Canis familiaris	Hgf	NCBI	NCBI:403441
Macaca fascicularis	Hgf	NCBI	NCBI:102133907
Rattus norvegicus	Hgf	NCBI	NCBI:24446
Macaca mulatta	Hgf	NCBI	NCBI:708316

Name
Email *

	Sorry, but the email address you supplied was invalid.