Hgf - hepatocyte growth factor Gene

Rattus norvegicus

Also known as HPTA

Gene ID: 24446 | Gene type: protein coding

About Hgf

Summary

Enables growth factor activity. Involved in several processes, including animal organ regeneration; positive regulation of angiogenesis; and positive regulation of myelination. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Hgf Products(1)

mRNA	Protein	Name
NM_017017.2	NP_058713.1	hepatocyte growth factor preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor activity	IMP IMP: Inferred from mutant phenotype	1826679	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	1826679	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	19638569	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	16885537	RGD
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	17549731	RGD
involved in positive regulation of myelination	IDA IDA: Inferred from direct assay	17549731	RGD
involved in positive regulation of neuron projection regeneration	IDA IDA: Inferred from direct assay	17549731	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19638569	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hepatocyte growth factor

SF	hepatopoeitin-A
hepatopoietin-A	scatter factor

Recombinant Hgf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71688	HGF Protein, Rat (GST)	P17945 (T477-L728)	≥95%
HY-P73101	HGF Protein, Rat (HEK293)	NP_058713.1 (Q33-L728)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0020	Eldecalcitol		99.94%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137455	Terevalefim	Activator	99.89%	Phase 3
HY-18696	AMG-337		99.43%	Phase 2

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99250	Onartuzumab	Inhibitor	99.62%	Phase 3
HY-P99196	Ficlatuzumab	Inhibitor	99.21%	Phase 3
HY-P99217	Rilotumumab	Inhibitor	99.10%	Phase 3
HY-P99192	Emibetuzumab	Inhibitor	95.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116282D	Dextran sulfate sodium salt (MW 450000-550000)		/	Unkown
HY-16969	Dihexa	Activator	98.92%	Unkown
HY-114363A	SRI 31215 TFA	Inhibitor	98.53%	Unkown
HY-106961	ONO 1301	Agonist	99.06%	Unkown
HY-W014940	Ethylene glycol dimethacrylate		99.52%	Unkown
HY-P1415A	Norleual TFA		99.32%	Unkown
HY-154988	MARK4 inhibitor 4		99.23%	Unkown
HY-145263	VD2173	Inhibitor	/	Unkown
HY-N13286	Glycozolidal	Inhibitor	99.92%	Unkown
HY-10338A	Foretinib phosphate	Inhibitor	/	Unkown
HY-106961A	(Z)-ONO 1301	Agonist	/	Unkown
HY-120159	GS-493	Inhibitor	/	Unkown
HY-P1415	Norleual		/	Unkown
HY-RS06152	HGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990949	Umikibart		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hgf	NCBI	NCBI:3082
Canis familiaris	Hgf	NCBI	NCBI:403441
Macaca fascicularis	Hgf	NCBI	NCBI:102133907
Mus musculus	Hgf	NCBI	NCBI:15234
Macaca mulatta	Hgf	NCBI	NCBI:708316

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