MAGEB6 - MAGE family member B6 Gene

Homo sapiens

Also known as CT3.4; MAGE-B6; MAGEB6A

Gene ID: 158809 | Gene type: protein coding

About MAGEB6

Cytogenetic location: Xp21.3 Genomic coordinates (GRCh38): X:26,192,440-26,195,646 (from NCBI)

This gene has 1 transcript (splice variant), 232 orthologues and 37 paralogues. Restricted expression toward testis (RPKM 2.3).

Summary

This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each Other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is expressed in testis, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]

MAGEB6 Products(1)

mRNA	Protein	Name
NM_173523.2	NP_775794.2	melanoma-associated antigen B6

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23275563	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEB6 Protein Structure

MAGE_N

MAGE

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

melanoma-associated antigen B6

MAGE-B6 antigen

MAGEB6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAGEB6	Q8N7X4	AGTR1	Homo sapiens	Q6NUP5	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	AGTR1	Homo sapiens	Q6NUP5	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	AGTR1	Homo sapiens	Q6NUP5	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	APBA2	Homo sapiens	Q99767-2	Y2H Array	32296183
Intra	MAGEB6	Q8N7X4	APBA2	Homo sapiens	Q99767-2	Y2H Prey Pooling	32296183
Intra	MAGEB6	Q8N7X4	ROBO1	Homo sapiens	Q2M1J3	Y2H Array	32296183
Intra	MAGEB6	Q8N7X4	ROBO1	Homo sapiens	Q2M1J3	Y2H Prey Pooling	32296183
Intra	MAGEB6	Q8N7X4	F8	Homo sapiens	P00451-2	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	F8	Homo sapiens	P00451-2	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	F8	Homo sapiens	P00451-2	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	CLN3	Homo sapiens	Q13286	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	CLN3	Homo sapiens	Q13286	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	CLN3	Homo sapiens	Q13286	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	HSP90AB1	Homo sapiens	P08238	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	HSP90AB1	Homo sapiens	P08238	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	HSP90AB1	Homo sapiens	P08238	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	PRDX1	Homo sapiens	Q06830	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	PRDX1	Homo sapiens	Q06830	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	PRDX1	Homo sapiens	Q06830	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	CCT8	Homo sapiens	P50990	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	CCT8	Homo sapiens	P50990	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	CCT8	Homo sapiens	P50990	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	TPPP	Homo sapiens	O94811	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	TPPP	Homo sapiens	O94811	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	TPPP	Homo sapiens	O94811	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	EEF1D	Homo sapiens	P29692-2	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	EEF1D	Homo sapiens	P29692-2	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	DNM1L	Homo sapiens	O00429-3	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	DNM1L	Homo sapiens	O00429-3	Y2H Pooling	32814053
Intra	MAGEB6	Q8N7X4	DNM1L	Homo sapiens	O00429-3	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	PHC2	Homo sapiens	Q8IXK0	Y2H Array	25416956
Intra	MAGEB6	Q8N7X4	PHC2	Homo sapiens	Q8IXK0	Y2H Prey Pooling	25416956
Intra	MAGEB6	Q8N7X4	SERPINA1	Homo sapiens	P01009	Validated Y2H	32814053
Intra	MAGEB6	Q8N7X4	SERPINA1	Homo sapiens	P01009	Y2H Array	32814053
Intra	MAGEB6	Q8N7X4	SERPINA1	Homo sapiens	P01009	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 6

RP6	Retinitis Pigmentosa, X-Linked Recessive, 6
Retinitis Pigmentosa-6, X-Linked Recessive

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07972	MAGEB6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAGEB6	RGD	RGD:1565662

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