DCC - DCC netrin 1 receptor Gene

Homo sapiens

Also known as CRC18; CRCR1; MRMV1; HGPPS2; IGDCC1; NTN1R1

Gene ID: 1630 | Gene type: protein coding

About DCC

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:52,340,197-53,535,899 (from NCBI)

This gene has 18 transcripts (splice variants), 193 orthologues, 36 paralogues and is associated with 109 phenotypes. Biased expression in testis (RPKM 2.4), brain (RPKM 1.4) and 2 other tissues.

Summary

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces Apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal Cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

DCC Products(1)

mRNA	Protein	Name
NM_005215.4	NP_005206.2	netrin receptor DCC

DCC Protein Structure

Ig_2

I-set

fn3

Neogenin_C

0
300
600
900
1200
1447 a.a.

Protein Preferred Names

Protein Names

netrin receptor DCC

colorectal cancer suppressor

Recombinant DCC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78745	Netrin receptor DCC/DCC Protein, Human (HEK293, His)	P43146-1 (F32-N1097)	≥95%

Related Diseases

Diseases

Alias

Mirror Movements 1

Congenital Mirror Movement Disorder	Bimanual Synergia
Congenital Mirror Movements	Familial Congenital Controlateral Synkinesia
Familial Congenital Mirror Movements	Hereditary Congenital Controlateral Synkinesia
Hereditary Congenital Mirror Movements	Isolated Congenital Controlateral Synkinesia
Isolated Congenital Mirror Movements	Mirror Movements
MRMV1	Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum
Mirror Movements, Congenital	Bimanual Synkinesis
Cmm	Mirror Movements, Type 1

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 2, With Impaired Intellectual Development

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2	HGPPS2
Developmental Split-Brain Syndrome	Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 2, With Impaired Intellectual Development

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Gaze Palsy, Familial Horizontal, With Progressive Scoliosis 1

Hgpps	Horizontal Gaze Palsy With Progressive Scoliosis
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis	HGPPS1
Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, 1	Gaze Palsy, Horizontal, With Progressive Scoliosis
Progressive External Ophthalmoplegia And Scoliosis	Familial Horizontal Gaze Palsy With Progressive Scoliosis
Familial Idiopathic Scoliosis Associated With Congenital Encephalopathy	Familial Infantile Scoliosis Associated With Bilateral Paralysis Of Conjugate Gaze
Ophthalmoplegia, Progressive External, And Scoliosis	Gaze Palsy, Familial Horizontal, With Progressive Scoliosis, Type 1

Corpus Callosum, Agenesis Of

Corpus Callosum Agenesis	Agenesis Of The Corpus Callosum
Isolated Corpus Callosum Agenesis	Acc
Non Rare In Europe: Isolated Corpus Callosum Agenesis	Congenital Malformation Of Corpus Callosum
Deformity Of Corpus Callosum	Absence Of Corpus Callosum
Absent Corpus Callosum	Acc - [Agenesis Of Corpus Callosum]
Aplasia Of Corpus Callosum	Congenital Absence Of Corpus Callosum
Hypoplastic Corpus Callosum	Hypoplasia Of Corpus Callosum

Intellectual Disability - Hypoplastic Corpus Callosum - Preauricular Tag

Da Silva Syndrome

Intellectual Disability-Hypoplastic Corpus Callosum-Preauricular Tag Syndrome

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Corpus Callosum, Partial Agenesis Of, X-Linked

X-Linked Complicated Corpus Callosum Dysgenesis	Corpus Callosum, Partial Agenesis Of
Partial Agenesis Of The Corpus Callosum	Partial Agenesis Of Corpus Callosum
Agenesis Of The Corpus Callosum, X-Linked, Partial	ACCPX
Agenesis, Corpus Callosum, Partial

Non-Syndromic X-Linked Intellectual Disability Arx-Related

Arx-Related Intellectual Disability	Mrxarx
X-Linked Mental Retardation 29	X-Linked Mental Retardation 29 And Others
X-Linked Mental Retardation 32	X-Linked Mental Retardation 33
X-Linked Mental Retardation 38	X-Linked Mental Retardation 43
X-Linked Mental Retardation 76	X-Linked Mental Retardation 87
X-Linked Mental Retardation With Or Without Seizures Arx-Related	Mental Retardation, X-Linked, Type 29 And Others

Scoliosis

Gastric Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Stomach

Squamous Cell Carcinoma Of The Stomach

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112306	Ripretinib		98.90%	Yes

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13024	Rebastinib		99.91%	Phase 2
HY-136256	Vimseltinib	Inhibitor	99.08%	Phase 2
HY-B0791	Altiratinib	Inhibitor	98.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-Y1092	N,N-Dicyclohexylcarbodiimide(DCC)		99.75%	Unkown
HY-160699	DCC-3116	Inhibitor	99.25%	Unkown
HY-W074890	Palmitoylglycine	Modulator	99.74%	Unkown
HY-100855	DC_C66	Inhibitor	/	Unkown
HY-117074	BMS-247243		/	Unkown
HY-157262	Methyl isonicotinate-(CH2)2-COOH		/	Unkown
HY-163008	Dicamba-5-aminopentanoic acid		/	Unkown
HY-RS03571	DCC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DCC	VGNC	VGNC:61363
Mus musculus	DCC	MGD	MGI:94869
Canis familiaris	DCC	VGNC	VGNC:39799
Macaca mulatta	DCC	VGNC	VGNC:71746
Bos taurus	DCC	VGNC	VGNC:109406
Rattus norvegicus	DCC	RGD	RGD:2492
Others	DCC	NCBI

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