CCDC146 - coiled-coil domain containing 146 Gene

Homo sapiens

Also known as MBO2

Gene ID: 57639 | Gene type: protein coding

About CCDC146

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:77,122,615-77,295,204 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in testis (RPKM 14.9), skin (RPKM 7.4) and 22 other tissues.

Summary

Located in centriole. [provided by Alliance of Genome Resources, Apr 2022]

CCDC146 Products(1)

mRNA	Protein	Name
NM_020879.3	NP_065930.2	coiled-coil domain-containing protein 146

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in spermatid development	IMP IMP: Inferred from mutant phenotype	38441556	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in axoneme	IDA IDA: Inferred from direct assay	38441556	GOA
located in centriole	IDA IDA: Inferred from direct assay	25074808	GOA
located in centrosome	IDA IDA: Inferred from direct assay	30094225	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	38441556	GOA
located in midbody	IDA IDA: Inferred from direct assay	38441556	GOA
located in sperm flagellum	IDA IDA: Inferred from direct assay	38441556	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

coiled-coil domain-containing protein 146

CCDC146 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CCDC146	Q8IYE0	CENPH	Homo sapiens	Q9H3R5	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	CENPH	Homo sapiens	Q9H3R5	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	CENPH	Homo sapiens	Q9H3R5	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT38	Homo sapiens	O76015	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT38	Homo sapiens	O76015	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT38	Homo sapiens	O76015	Y2H Array	29892012
Intra	CCDC146	Q8IYE0	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	GRAMD4	Homo sapiens	Q6IC98	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	GRAMD4	Homo sapiens	Q6IC98	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	TRIML2	Homo sapiens	Q8N7C3	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	TRIML2	Homo sapiens	Q8N7C3	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	TRIML2	Homo sapiens	Q8N7C3	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	CDR2L	Homo sapiens	Q86X02	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	CDR2L	Homo sapiens	Q86X02	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	PROSER3	Homo sapiens	Q2NL68	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	PROSER3	Homo sapiens	Q2NL68	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	AKAP9	Homo sapiens	Q6PJH3	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	AKAP9	Homo sapiens	Q6PJH3	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	LHX3	Homo sapiens	Q9UBR4-2	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	LHX3	Homo sapiens	Q9UBR4-2	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	LHX3	Homo sapiens	Q9UBR4-2	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	KRT26	Homo sapiens	Q7Z3Y9	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT26	Homo sapiens	Q7Z3Y9	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	VPS28	Homo sapiens	Q9UK41-2	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	VPS28	Homo sapiens	Q9UK41-2	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	VPS28	Homo sapiens	Q9UK41-2	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	N4BP3	Homo sapiens	O15049	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	N4BP3	Homo sapiens	O15049	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	PPP2R3C	Homo sapiens	Q969Q6	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	PPP2R3C	Homo sapiens	Q969Q6	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	PPP2R3C	Homo sapiens	Q969Q6	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT24	Homo sapiens	Q2M2I5	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT24	Homo sapiens	Q2M2I5	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	SH3BP1	Homo sapiens	Q9Y3L3	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	SH3BP1	Homo sapiens	Q9Y3L3	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	SH3BP1	Homo sapiens	Q9Y3L3	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	NUP62	Homo sapiens	P37198	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	NUP62	Homo sapiens	P37198	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT16	Homo sapiens	P08779	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT16	Homo sapiens	P08779	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	TXLNA	Homo sapiens	P40222	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	TXLNA	Homo sapiens	P40222	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	GMNN	Homo sapiens	O75496	Anti Tag CoIP	33961781
Intra	CCDC146	Q8IYE0	GMNN	Homo sapiens	O75496	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	GMNN	Homo sapiens	O75496	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	GMNN	Homo sapiens	O75496	Y2H Array	31515488
Intra	CCDC146	Q8IYE0	NAP1L2	Homo sapiens	Q9ULW6	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	NAP1L2	Homo sapiens	Q9ULW6	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	NAP1L2	Homo sapiens	Q9ULW6	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	INSYN1	Homo sapiens	Q2T9L4	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	INSYN1	Homo sapiens	Q2T9L4	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	BLOC1S2	Homo sapiens	Q6QNY1	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	GPRASP2	Homo sapiens	Q96D09	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	GPRASP2	Homo sapiens	Q96D09	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	GPRASP2	Homo sapiens	Q96D09	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	THOC7	Homo sapiens	Q6I9Y2	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	THOC7	Homo sapiens	Q6I9Y2	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	CEP44	Homo sapiens	Q9C0F1	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	CEP44	Homo sapiens	Q9C0F1	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	CEP44	Homo sapiens	Q9C0F1	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	CCDC197	Homo sapiens	Q8NCU1	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	CCDC197	Homo sapiens	Q8NCU1	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	CCDC197	Homo sapiens	Q8NCU1	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	PDE4DIP	Homo sapiens	Q5VU43-2	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183
Intra	CCDC146	Q8IYE0	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	32296183
Intra	CCDC146	Q8IYE0	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT86	Homo sapiens	O43790	Y2H Prey Pooling	32296183
Intra	CCDC146	Q8IYE0	KRT86	Homo sapiens	O43790	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lymphogranuloma Venereum

Climatic Or Tropical Bubo	Durand-Nicolas-Favre Disease
Lymphogranuloma Inguinale	Poradenitis Inguinale
Strumous Bubo	Lgv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02033	CCDC146 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CCDC146	VGNC	VGNC:60464
Rattus norvegicus	CCDC146	RGD	RGD:1559535
Canis familiaris	CCDC146	VGNC	VGNC:38798
Bos taurus	CCDC146	VGNC	VGNC:26854
Macaca mulatta	CCDC146	VGNC	VGNC:70902
Mus musculus	CCDC146	MGD	MGI:1922422

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