2. Gene
  3. MARK2 - microtubule affinity regulating kinase 2 Gene

MARK2 - microtubule affinity regulating kinase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EMK1; EMK-1; PAR-1; Par1b; Par-1b

Gene ID: 2011 | Gene type: protein coding

About MARK2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,839,110-63,911,020 (from NCBI)

This gene has 23 transcripts (splice variants), 236 orthologues and 3 paralogues. Ubiquitous expression in esophagus (RPKM 11.9), colon (RPKM 10.6) and 25 other tissues.

Summary

This gene encodes a member of the Par-1 family of serine/threonine protein kinases. The protein is an important regulator of cell polarity in epithelial and neuronal cells, and also controls the stability of microtubules through phosphorylation and inactivation of several microtubule-associating proteins. The protein localizes to cell membranes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

MARK2 Products(5)

mRNA Protein Name
NM_001039469.3 NP_001034558.2 serine/threonine-protein kinase MARK2 isoform d
NM_001163296.2 NP_001156768.1 serine/threonine-protein kinase MARK2 isoform e
NM_001163297.2 NP_001156769.1 serine/threonine-protein kinase MARK2 isoform f
NM_004954.5 NP_004945.4 serine/threonine-protein kinase MARK2 isoform c
NM_017490.4 NP_059672.2 serine/threonine-protein kinase MARK2 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14676191 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14976552 GOA
enables tau-protein kinase activity IMP
IMP: Inferred from mutant phenotype
23666762 GOA
Biological Process GO Annotation Evidence Reference Source
involved in establishment of cell polarity IDA
IDA: Inferred from direct assay
12429843 GOA
involved in establishment or maintenance of epithelial cell apical/basal polarity IDA
IDA: Inferred from direct assay
15324659 GOA
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
14976552 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
10542369 GOA
involved in positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
12429843 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14976552 GOA
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23666762 GOA
involved in regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
20194617 GOA
involved in regulation of microtubule cytoskeleton organization IDA
IDA: Inferred from direct assay
10542369 GOA
Cellular Component GO Annotation Evidence Reference Source
located in actin filament IDA
IDA: Inferred from direct assay
23902687 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23666762 GOA
located in dendrite IDA
IDA: Inferred from direct assay
23666762 GOA
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
23902687 GOA
located in membrane IMP
IMP: Inferred from mutant phenotype
14976552 GOA
located in microtubule bundle IDA
IDA: Inferred from direct assay
23902687 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23902687 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MARK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (53 - 304)

KA1

KA1: Kinase associated domain 1 (745 - 788)

  • 0
  • 200
  • 400
  • 600
  • 788 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase MARK2

ELKL motif kinase 1

MARK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra MARK2 Q7KZI7 PARD6G Homo sapiens Q9BYG4
Anti Tag CoIP
14676191
Intra MARK2 Q7KZI7 YWHAH Homo sapiens Q04917
Pull Down
32707033
Intra MARK2 Q7KZI7 YWHAH Homo sapiens Q04917
Anti Tag CoIP
35271311
Intra MARK2 Q7KZI7 YWHAH Homo sapiens Q04917
Anti Tag CoIP
19615732
Intra MARK2 Q7KZI7 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra MARK2 Q7KZI7 YWHAZ Homo sapiens P63104
TAP
16306228
Intra MARK2 Q7KZI7 YWHAZ Homo sapiens P63104
Pull Down
32707033
Intra MARK2 Q7KZI7 YWHAZ Homo sapiens P63104
Anti Tag CoIP
35271311
Intra MARK2 Q7KZI7 YWHAB Homo sapiens P31946
Pull Down
32707033
Intra MARK2 Q7KZI7 YWHAB Homo sapiens P31946
Anti Tag CoIP
16959763
Intra MARK2 Q7KZI7 YWHAB Homo sapiens P31946
Anti Tag CoIP
35271311
Intra MARK2 Q7KZI7 YWHAG Homo sapiens P61981
Anti Tag CoIP
35271311
Intra MARK2 Q7KZI7 YWHAG Homo sapiens P61981
Pull Down
32707033
Intra MARK2 Q7KZI7 YWHAG Homo sapiens P61981
Anti Tag CoIP
16959763
Cross MARK2 Q7KZI7 cagA Helicobacter pylori P55980
X-Ray Diffraction
19966800
Cross MARK2 Q7KZI7 cagA Helicobacter pylori P55980
GMS
19966800
Cross MARK2 Q7KZI7 cagA Helicobacter pylori P55980
Pull Down
19966800
Cross MARK2 Q7KZI7 cagA Helicobacter pylori P55980
SLCA
19966800
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120877 MRT199665 99.74% Unkown
HY-139604 PCC0208017 98.03% Unkown
HY-148062 RSS0680 98.03% Unkown
HY-120877A (R)-MRT199665 98.70% Unkown
HY-RS08150 MARK2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MARK2 VGNC VGNC:74634
Canis familiaris MARK2 VGNC VGNC:43024
Mus musculus MARK2 MGD MGI:99638
Bos taurus MARK2 VGNC VGNC:31248
Rattus norvegicus MARK2 RGD RGD:708483
Felis catus MARK2 VGNC VGNC:63389