HTRA3 - HtrA serine peptidase 3 Gene

Homo sapiens

Also known as Prsp; Tasp

Gene ID: 94031 | Gene type: protein coding

About HTRA3

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,269,754-8,307,098 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in ovary (RPKM 19.8), gall bladder (RPKM 16.9) and 19 other tissues.

Summary

Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

HTRA3 Products(2)

mRNA	Protein	Name
NM_001297559.3	NP_001284488.1	serine protease HTRA3 isoform 2 precursor
NM_053044.5	NP_444272.1	serine protease HTRA3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	18387192	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26110759	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22229724	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	22229724	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in proteolysis	IDA IDA: Inferred from direct assay	18387192	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTRA3 Protein Structure

Kazal_2

Trypsin_2

PDZ_2

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

serine protease HTRA3

high-temperature requirement factor A3

HTRA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HTRA3	P83110	HTRA4	Homo sapiens	P83105	Anti Tag CoIP	25002585
Intra	HTRA3	P83110	HTRA3	Homo sapiens	P83110	GMS	26110759
Intra	HTRA3	P83110	XIAP	Homo sapiens	P98170	Anti Bait CoIP	31260151
Intra	HTRA3	P83110	ACTB	Homo sapiens	P60709	Anti Bait CoIP	29477555
Intra	HTRA3	P83110	XIAP	Homo sapiens	P98170	PLA	31260151
Intra	HTRA3	P83110	XIAP	Homo sapiens	P98170	Pull Down	31260151
Intra	HTRA3	P83110	XIAP	Homo sapiens	P98170	Confocal	31260151
Intra	HTRA3	P83110	HTRA3	Homo sapiens	P83110	GMS	31899476
Intra	HTRA3	P83110	HTRA3	Homo sapiens	P83110	X-Ray Diffraction	26110759
Intra	HTRA3	P83110	TCP1	Homo sapiens	P17987	Anti Bait CoIP	29477555
Cross	HTRA3	P83110	CSN2	Bos taurus	P02666	GMS	26110759
Cross	HTRA3	P83110	CSN2	Bos taurus	P02666	Protease Assay	26110759

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06488	HTRA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HTRA3	MGD	MGI:1925808
Felis catus	HTRA3	VGNC	VGNC:62856
Bos taurus	HTRA3	VGNC	VGNC:59337
Canis familiaris	HTRA3	VGNC	VGNC:41837
Rattus norvegicus	HTRA3	RGD	RGD:1308120
Macaca mulatta	HTRA3	VGNC	VGNC:82160
Others	HTRA3	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.