HTRA3 - HtrA serine peptidase 3 Gene

Homo sapiens

Also known as Prsp; Tasp

Gene ID: 94031 | Gene type: protein coding

About HTRA3

Cytogenetic location: 4p16.1 Genomic coordinates (GRCh38): 4:8,269,754-8,307,098 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues and 3 paralogues. Broad expression in ovary (RPKM 19.8), gall bladder (RPKM 16.9) and 19 other tissues.

Summary

Enables endopeptidase activity; identical protein binding activity; and serine-type peptidase activity. Involved in proteolysis. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

HTRA3 Products(2)

mRNA	Protein	Name
NM_001297559.3	NP_001284488.1	serine protease HTRA3 isoform 2 precursor
NM_053044.5	NP_444272.1	serine protease HTRA3 isoform 1 precursor

HTRA3 Protein Structure

Kazal_2

Trypsin_2

PDZ_2

0
100
200
300
400
453 a.a.

Protein Preferred Names

Protein Names

serine protease HTRA3

high-temperature requirement factor A3

Related Diseases

Diseases

Alias

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06488	HTRA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HTRA3	MGD	MGI:1925808
Felis catus	HTRA3	VGNC	VGNC:62856
Bos taurus	HTRA3	VGNC	VGNC:59337
Canis familiaris	HTRA3	VGNC	VGNC:41837
Rattus norvegicus	HTRA3	RGD	RGD:1308120
Macaca mulatta	HTRA3	VGNC	VGNC:82160
Others	HTRA3	NCBI

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