EIF3D - eukaryotic translation initiation factor 3 subunit D Gene

Homo sapiens

Also known as EIF3S7; eIF3-p66; eIF3-zeta

Gene ID: 8664 | Gene type: protein coding

About EIF3D

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:36,510,855-36,529,166 (from NCBI)

This gene has 12 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in ovary (RPKM 83.0), lymph node (RPKM 75.1) and 25 other tissues.

Summary

Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq, Jul 2008]

EIF3D Products(1)

mRNA	Protein	Name
NM_003753.4	NP_003744.1	eukaryotic translation initiation factor 3 subunit D

EIF3D Protein Structure

eIF-3_zeta

0
100
200
300
400
500
548 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit D

eIF3 p66

EIF3D Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3D	O15371	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	EIF3D	O15371	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Array	32296183
Intra	EIF3D	O15371	CCDC57	Homo sapiens	Q2TAC2-2	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	HOOK2	Homo sapiens	Q96ED9-2	Y2H Array	32296183
Intra	EIF3D	O15371	HOOK2	Homo sapiens	Q96ED9-2	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	HOOK2	Homo sapiens	Q96ED9-2	Validated Y2H	32296183
Intra	EIF3D	O15371	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	EIF3D	O15371	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	EIF3D	O15371	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	EIF3D	O15371	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	EIF3D	O15371	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
Intra	EIF3D	O15371	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	EIF3D	O15371	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	EIF3D	O15371	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	EIF3D	O15371	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	EIF3D	O15371	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	EIF3D	O15371	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	33961781
Intra	EIF3D	O15371	EIF3E	Homo sapiens	P60228	Pull Down	23623729
Intra	EIF3D	O15371	EIF3E	Homo sapiens	P60228	SLCA	18599441
Intra	EIF3D	O15371	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	EIF3D	O15371	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	POLR2G	Homo sapiens	P62487	Validated Y2H	32296183
Intra	EIF3D	O15371	ANKRD28	Homo sapiens	O15084	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	ANKRD28	Homo sapiens	O15084	Y2H Array	32296183
Intra	EIF3D	O15371	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	EIF3D	O15371	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	EIF3D	O15371	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	EIF3D	O15371	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Cross	EIF3D	O15371	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034
Intra	EIF3D	O15371	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	25416956
Intra	EIF3D	O15371	SAT1	Homo sapiens	P21673	Y2H Array	25416956
Intra	EIF3D	O15371	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	HSF2BP	Homo sapiens	O75031	Validated Y2H	32296183
Intra	EIF3D	O15371	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	EIF3D	O15371	TRIM27	Homo sapiens	P14373	Validated Y2H	32296183
Intra	EIF3D	O15371	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	EIF3D	O15371	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	EIF3D	O15371	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	BEND5	Homo sapiens	Q7L4P6	Validated Y2H	25416956
Intra	EIF3D	O15371	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	EIF3D	O15371	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	EIF3D	O15371	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	EIF3D	O15371	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	DVL3	Homo sapiens	Q92997	Validated Y2H	32296183
Intra	EIF3D	O15371	TRIM23	Homo sapiens	P36406	Validated Y2H	32296183
Intra	EIF3D	O15371	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	TRIM23	Homo sapiens	P36406	Y2H Array	32296183
Intra	EIF3D	O15371	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	25416956
Intra	EIF3D	O15371	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	EIF3D	O15371	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	EIF3D	O15371	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956
Intra	EIF3D	O15371	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	EIF3D	O15371	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	EIF3D	O15371	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	EIF3D	O15371	MORN3	Homo sapiens	Q6PF18	Y2H Array	32296183
Intra	EIF3D	O15371	MORN3	Homo sapiens	Q6PF18	Y2H Prey Pooling	32296183
Intra	EIF3D	O15371	MORN3	Homo sapiens	Q6PF18	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168106	ZMF-24		/	Unkown
HY-RS04260	EIF3D Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF3D	MGD	MGI:1933181
Canis familiaris	EIF3D	VGNC	VGNC:40270
Bos taurus	EIF3D	VGNC	VGNC:28394
Felis catus	EIF3D	VGNC	VGNC:61782
Macaca mulatta	EIF3D	VGNC	VGNC:72192
Rattus norvegicus	EIF3D	RGD	RGD:1303255

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