PDCD6 - programmed cell death 6 Gene

Homo sapiens

Also known as ALG2; ALG-2; PEF1B

Gene ID: 10016 | Gene type: protein coding

About PDCD6

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:271,646-314,974 (from NCBI)

This gene has 12 transcripts (splice variants), 189 orthologues and 20 paralogues. Ubiquitous expression in colon (RPKM 23.5), adrenal (RPKM 21.4) and 25 other tissues.

Summary

This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to Other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, Apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

PDCD6 Products(5)

mRNA	Protein	Name
NM_001267556.2	NP_001254485.1	programmed cell death protein 6 isoform 2
NM_001267557.2	NP_001254486.1	programmed cell death protein 6 isoform 3
NM_001267558.2	NP_001254487.1	programmed cell death protein 6 isoform 4
NM_001267559.2	NP_001254488.1	programmed cell death protein 6 isoform 5
NM_013232.4	NP_037364.1	programmed cell death protein 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	25667979	GOA
enables calcium-dependent protein binding	IMP IMP: Inferred from mutant phenotype	14999017	GOA
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	12445460	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11883939	GOA
enables protein dimerization activity	IPI IPI: Inferred from physical interaction	11883899	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11278427	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25667979	GOA
enables protein-macromolecule adaptor activity	IMP IMP: Inferred from mutant phenotype	19520058	GOA
enables protein-membrane adaptor activity	IMP IMP: Inferred from mutant phenotype	16957052	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IMP IMP: Inferred from mutant phenotype	27716508	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in COPII vesicle coating	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	21122810	GOA
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	21122810	GOA
involved in negative regulation of TOR signaling	IDA IDA: Inferred from direct assay	21893193	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	21893193	GOA
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	21893193	GOA
involved in neural crest cell development	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in neural crest formation	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	21893193	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	16132846	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	21893193	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	21893193	GOA
involved in positive regulation of protein monoubiquitination	IMP IMP: Inferred from mutant phenotype	27716508	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	12445460	GOA
involved in vascular endothelial growth factor receptor-2 signaling pathway	IDA IDA: Inferred from direct assay	21893193	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of COPII vesicle coat	IDA IDA: Inferred from direct assay	27716508	GOA
part of Cul3-RING ubiquitin ligase complex	IDA IDA: Inferred from direct assay	27716508	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	11278427	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	21122810	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17196169	GOA
located in endoplasmic reticulum exit site	IDA IDA: Inferred from direct assay	27813252	GOA
located in endoplasmic reticulum exit site	IMP IMP: Inferred from mutant phenotype	16957052	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11278427	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17196169	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD6 Protein Structure

EF-hand_8

EF-hand_7

0
100
191 a.a.

Protein Preferred Names

Protein Names

programmed cell death protein 6

apoptosis-linked gene 2 protein homolog

PDCD6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDCD6	O75340	KDR	Homo sapiens	P35968	Anti Bait CoIP	21893193
Intra	PDCD6	O75340	KDR	Homo sapiens	P35968	Y2H	21893193
Intra	PDCD6	O75340	KDR	Homo sapiens	P35968	Anti Tag CoIP	21893193
Intra	PDCD6	O75340	ANXA11	Homo sapiens	Q5T0G8	Validated Y2H	25416956
Intra	PDCD6	O75340	ANXA11	Homo sapiens	Q5T0G8	Y2H Array	25416956
Intra	PDCD6	O75340	ANXA11	Homo sapiens	Q5T0G8	Y2H Prey Pooling	25416956
Intra	PDCD6	O75340	SEC31A	Homo sapiens	O94979	Pull Down	17196169
Intra	PDCD6	O75340	SEC31A	Homo sapiens	O94979	Anti Tag CoIP	35271311
Intra	PDCD6	O75340	SEC31A	Homo sapiens	O94979	Confocal	17196169
Intra	PDCD6	O75340	SEC31A	Homo sapiens	O94979	Pull Down	18256029
Intra	PDCD6	O75340	VPS37C	Homo sapiens	A5D8V6	Y2H Prey Pooling	25416956
Intra	PDCD6	O75340	VPS37C	Homo sapiens	A5D8V6	Y2H Array	25416956
Intra	PDCD6	O75340	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	PDCD6	O75340	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	PDCD6	O75340	BAG4	Homo sapiens	O95429	Validated Y2H	32296183
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	Far-WB	18940611
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	Pull Down	18940611
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	Far-WB	17196169
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	Y2H Array	31515488
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	Pull Down	17196169
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	X-Ray Diffraction	18940611
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	Pull Down	18256029
Intra	PDCD6	O75340	PDCD6IP	Homo sapiens	Q8WUM4	Anti Tag CoIP	35271311
Intra	PDCD6	O75340	PEF1	Homo sapiens	Q9UBV8	Anti Tag CoIP	35271311
Intra	PDCD6	O75340	PEF1	Homo sapiens	Q9UBV8	Y2H Pooling	16189514
Intra	PDCD6	O75340	PEF1	Homo sapiens	Q9UBV8	Validated Y2H	32296183
Intra	PDCD6	O75340	PEF1	Homo sapiens	Q9UBV8	Y2H Array	25416956
Intra	PDCD6	O75340	PEF1	Homo sapiens	Q9UBV8	Y2H	21988832
Intra	PDCD6	O75340	PEF1	Homo sapiens	Q9UBV8	Y2H Prey Pooling	25416956
Intra	PDCD6	O75340	DAPK1	Homo sapiens	P53355	Y2H	16132846
Intra	PDCD6	O75340	DCTN2	Homo sapiens	Q13561	Anti Tag CoIP	26950892
Intra	PDCD6	O75340	ANXA11	Homo sapiens	P50995	Y2H Array	31515488
Intra	PDCD6	O75340	PTPN23	Homo sapiens	Q9H3S7	Anti Tag CoIP	17174262
Intra	PDCD6	O75340	PTPN23	Homo sapiens	Q9H3S7	Y2H	17174262
Intra	PDCD6	O75340	HEBP2	Homo sapiens	Q9Y5Z4	Validated Y2H	25416956
Intra	PDCD6	O75340	HEBP2	Homo sapiens	Q9Y5Z4	Validated Y2H	32296183
Intra	PDCD6	O75340	HEBP2	Homo sapiens	Q9Y5Z4	Y2H Array	25416956
Intra	PDCD6	O75340	HEBP2	Homo sapiens	Q9Y5Z4	Anti Tag CoIP	35271311
Intra	PDCD6	O75340	HEBP2	Homo sapiens	Q9Y5Z4	Y2H Pooling	16189514
Intra	PDCD6	O75340	PLSCR3	Homo sapiens	Q9NRY6	Far-WB	18256029
Intra	PDCD6	O75340	PLSCR3	Homo sapiens	Q9NRY6	Pull Down	18256029
Intra	PDCD6	O75340	PLSCR3	Homo sapiens	Q9NRY6	ELISA	18256029
Intra	PDCD6	O75340	PLSCR3	Homo sapiens	Q9NRY6	SPR	18256029
Intra	PDCD6	O75340	PLSCR3	Homo sapiens	Q9NRY6	Anti Bait CoIP	18256029
Intra	PDCD6	O75340	PLSCR3	Homo sapiens	Q9NRY6	Anti Tag CoIP	18256029

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ocular Melanoma

Intraocular Melanoma	Uveal Melanoma
Eye Melanoma	Melanoma Of Eye
Melanoma Of The Uvea	Malignant Melanoma Of Eye

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10194	PDCD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10195	PDCD6IP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PDCD6	VGNC	VGNC:32663
Canis familiaris	PDCD6	VGNC	VGNC:44340
Rattus norvegicus	PDCD6	RGD	RGD:1311239
Felis catus	PDCD6	VGNC	VGNC:102284
Mus musculus	PDCD6	MGD	MGI:109283
Others	PDCD6	NCBI

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