COMMD3 - COMM domain containing 3 Gene

Homo sapiens

Also known as BUP; C10orf8

Gene ID: 23412 | Gene type: protein coding

About COMMD3

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:22,316,388-22,320,306 (from NCBI)

This gene has 15 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in heart (RPKM 26.0), appendix (RPKM 25.1) and 25 other tissues.

Summary

Predicted to be involved in sodium ion transport. Predicted to be located in extracellular region and ficolin-1-rich granule lumen. [provided by Alliance of Genome Resources, Apr 2022]

COMMD3 Products(1)

mRNA	Protein	Name
NM_012071.4	NP_036203.1	COMM domain-containing protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15799966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD3 Protein Structure

COMM_domain

0
100
195 a.a.

Protein Preferred Names

Protein Names

COMM domain-containing protein 3

protein Bup

COMMD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COMMD3	Q9UBI1	PIH1D2	Homo sapiens	Q8WWB5	Y2H Prey Pooling	32296183
Intra	COMMD3	Q9UBI1	PIH1D2	Homo sapiens	Q8WWB5	Y2H Array	32296183
Intra	COMMD3	Q9UBI1	CCDC93	Homo sapiens	Q567U6	Pull Down	25355947
Intra	COMMD3	Q9UBI1	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	33961781
Intra	COMMD3	Q9UBI1	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	37172566
Intra	COMMD3	Q9UBI1	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	28514442
Intra	COMMD3	Q9UBI1	CCDC93	Homo sapiens	Q567U6	Pull Down	30833792
Intra	COMMD3	Q9UBI1	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	37172566
Intra	COMMD3	Q9UBI1	COMMD1	Homo sapiens	Q8N668	Pull Down	15799966
Intra	COMMD3	Q9UBI1	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	33961781
Intra	COMMD3	Q9UBI1	COMMD1	Homo sapiens	Q8N668	Pull Down	30833792
Intra	COMMD3	Q9UBI1	COMMD2	Homo sapiens	Q86X83	Anti Tag CoIP	37172566
Intra	COMMD3	Q9UBI1	COMMD2	Homo sapiens	Q86X83	Y2H Prey Pooling	32296183
Intra	COMMD3	Q9UBI1	COMMD2	Homo sapiens	Q86X83	Y2H Array	32296183
Intra	COMMD3	Q9UBI1	COMMD2	Homo sapiens	Q86X83	Pull Down	30833792
Intra	COMMD3	Q9UBI1	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	37172566
Intra	COMMD3	Q9UBI1	CCDC22	Homo sapiens	O60826	Pull Down	30833792
Intra	COMMD3	Q9UBI1	COMMD8	Homo sapiens	Q9NX08	Pull Down	30833792
Intra	COMMD3	Q9UBI1	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	37172566
Intra	COMMD3	Q9UBI1	COMMD8	Homo sapiens	Q9NX08	Anti Tag CoIP	33961781
Intra	COMMD3	Q9UBI1	COMMD8	Homo sapiens	Q9NX08	Y2H	21900206

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myopathy, Distal, 4

Distal Myopathy With Posterior Leg And Anterior Hand Involvement	MPD4
Williams Distal Myopathy	Distal Muscular Dystrophy 4
Distal Abd-Filaminopathy	Distal Myopathy 4
Myopathy, Distal, Type 4

Opioid Abuse

Opioid-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03012	COMMD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	COMMD3	VGNC	VGNC:27584
Mus musculus	COMMD3	MGD	MGI:88218
Canis familiaris	COMMD3	VGNC	VGNC:39494
Rattus norvegicus	COMMD3	RGD	RGD:735116

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