COMMD2 - COMM domain containing 2 Gene

Homo sapiens

Also known as HSPC042

Gene ID: 51122 | Gene type: protein coding

About COMMD2

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,738,472-149,752,489 (from NCBI)

This gene has 7 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in thyroid (RPKM 7.0), lung (RPKM 6.4) and 25 other tissues.

Summary

Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

COMMD2 Products(1)

mRNA	Protein	Name
NM_016094.4	NP_057178.2	COMM domain-containing protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15799966	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COMMD2 Protein Structure

COMM_domain

0
100
199 a.a.

Protein Preferred Names

Protein Names

COMM domain-containing protein 2

COMMD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	COMMD2	Q86X83	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	28514442
Intra	COMMD2	Q86X83	CCDC93	Homo sapiens	Q567U6	Pull Down	25355947
Intra	COMMD2	Q86X83	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	33961781
Intra	COMMD2	Q86X83	CCDC93	Homo sapiens	Q567U6	Anti Tag CoIP	35271311
Intra	COMMD2	Q86X83	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	33961781
Intra	COMMD2	Q86X83	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	37172566
Intra	COMMD2	Q86X83	COMMD1	Homo sapiens	Q8N668	Pull Down	15799966
Intra	COMMD2	Q86X83	COMMD1	Homo sapiens	Q8N668	Anti Tag CoIP	35271311
Intra	COMMD2	Q86X83	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	28514442
Intra	COMMD2	Q86X83	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	35271311
Intra	COMMD2	Q86X83	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	37172566
Intra	COMMD2	Q86X83	CCDC22	Homo sapiens	O60826	Pull Down	23563313
Intra	COMMD2	Q86X83	CCDC22	Homo sapiens	O60826	Anti Tag CoIP	33961781
Intra	COMMD2	Q86X83	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	COMMD2	Q86X83	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	COMMD2	Q86X83	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	COMMD2	Q86X83	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	33961781
Intra	COMMD2	Q86X83	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	28514442
Intra	COMMD2	Q86X83	COMMD3	Homo sapiens	Q9UBI1	Anti Tag CoIP	37172566
Intra	COMMD2	Q86X83	COMMD3	Homo sapiens	Q9UBI1	Validated Y2H	32296183
Intra	COMMD2	Q86X83	COMMD3	Homo sapiens	Q9UBI1	GMS	37172566

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03011	COMMD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	COMMD2	VGNC	VGNC:102679
Canis familiaris	COMMD2	VGNC	VGNC:39493
Bos taurus	COMMD2	VGNC	VGNC:27583
Rattus norvegicus	COMMD2	RGD	RGD:1588810
Macaca mulatta	COMMD2	VGNC	VGNC:71341
Mus musculus	COMMD2	MGD	MGI:1098806

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