CBX6 - chromobox 6 Gene

Homo sapiens

Gene ID: 23466 | Gene type: protein coding

About CBX6

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:38,861,422-38,872,216 (from NCBI)

This gene has 3 transcripts (splice variants), 109 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 28.2), ovary (RPKM 14.0) and 24 other tissues.

Summary

Predicted to enable single-stranded RNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of PcG protein complex. Biomarker of glioblastoma. [provided by Alliance of Genome Resources, Apr 2022]

CBX6 Products(2)

mRNA	Protein	Name
NM_001303494.2	NP_001290423.1	chromobox protein homolog 6 isoform 2
NM_014292.5	NP_055107.3	chromobox protein homolog 6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18927235	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21282530	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of PcG protein complex	IDA IDA: Inferred from direct assay	21282530	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21282530	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CBX6 Protein Structure

Chromo

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

chromobox protein homolog 6

chromobox homolog 6

CBX6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CBX6	O95503	MOV10	Homo sapiens	Q9HCE1	TAP	21282530
Intra	CBX6	O95503	MOV10	Homo sapiens	Q9HCE1	Anti Tag CoIP	33961781
Intra	CBX6	O95503	PCGF2	Homo sapiens	P35227	Pull Down	21282530
Intra	CBX6	O95503	PCGF3	Homo sapiens	Q3KNV8	Anti Tag CoIP	21282530
Intra	CBX6	O95503	BMI1	Homo sapiens	P35226	TAP	27705803
Intra	CBX6	O95503	BMI1	Homo sapiens	P35226	TAP	24981860
Intra	CBX6	O95503	BMI1	Homo sapiens	P35226	Anti Tag CoIP	33961781
Intra	CBX6	O95503	BMI1	Homo sapiens	P35226	Anti Tag CoIP	21282530
Intra	CBX6	O95503	RNF2	Homo sapiens	Q99496	TAP	27705803
Intra	CBX6	O95503	RNF2	Homo sapiens	Q99496	Anti Tag CoIP	33961781
Intra	CBX6	O95503	RNF2	Homo sapiens	Q99496	TAP	21282530
Intra	CBX6	O95503	RNF2	Homo sapiens	Q99496	TAP	24981860
Intra	CBX6	O95503	PCGF1	Homo sapiens	Q9BSM1	Anti Tag CoIP	33961781
Intra	CBX6	O95503	RING1	Homo sapiens	Q06587	TAP	27705803
Intra	CBX6	O95503	RING1	Homo sapiens	Q06587	Pull Down	21282530
Intra	CBX6	O95503	RING1	Homo sapiens	Q06587	Anti Tag CoIP	21282530
Intra	CBX6	O95503	RING1	Homo sapiens	Q06587	Anti Tag CoIP	33961781
Intra	CBX6	O95503	RING1	Homo sapiens	Q06587	TAP	21282530

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Benign Pleural Mesothelioma

Mesothelioma Of Pleura	Benign Neoplasm Of Mesothelial Tissue Of Pleura
Pleural Malignant Mesothelioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02013	CBX6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CBX6	MGD	MGI:3512628
Bos taurus	CBX6	VGNC	VGNC:26819
Rattus norvegicus	CBX6	RGD	RGD:1307314

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