2. Gene
  3. PCGF1 - polycomb group ring finger 1 Gene

PCGF1 - polycomb group ring finger 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NSPC1; RNF68; RNF3A-2; 2010002K04Rik

Gene ID: 84759 | Gene type: protein coding

About PCGF1

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:74,505,043-74,507,695 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 7 paralogues. Ubiquitous expression in thyroid (RPKM 3.8), testis (RPKM 3.8) and 25 other tissues.

Summary

PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development (Nunes et al., 2001 [PubMed 11287196]). See also PCGF2 (MIM 600346).[supplied by OMIM, Aug 2008]

PCGF1 Products(1)

mRNA Protein Name
NM_032673.3 NP_116062.2 polycomb group RING finger protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16943429 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
16943429 GOA
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
26151332 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
16943429 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21282530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCGF1 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (47 - 85)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

polycomb group RING finger protein 1

RING finger protein 68

PCGF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PCGF1 Q9BSM1 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra
PCGF1 Q9BSM1 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra
PCGF1 Q9BSM1 CBX7 Homo sapiens O95931
Pull Down
21282530
Intra
PCGF1 Q9BSM1 CBX6 Homo sapiens O95503
Pull Down
21282530
Intra
PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
TAP
27705803
Intra
PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
27505670
Intra
PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
TAP
27505670
Intra
PCGF1 Q9BSM1 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
33961781
Intra
PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra
PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Pull Down
16943429
Intra
PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra
PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
TAP
27505670
Intra
PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Anti Tag CoIP
27505670
Intra
PCGF1 Q9BSM1 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra
PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
TAP
27505670
Intra
PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra
PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Y2H Array
22493164
Intra
PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
TAP
27705803
Intra
PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Anti Tag CoIP
22493164
Intra
PCGF1 Q9BSM1 RING1 Homo sapiens Q06587
Pull Down
16943429
Intra
PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Pull Down
16943429
Intra
PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Tag CoIP
16943429
Intra
PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
TAP
27505670
Intra
PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Bait CoIP
16943429
Intra
PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Tag CoIP
33961781
Intra
PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
Anti Tag CoIP
27505670
Intra
PCGF1 Q9BSM1 BCOR Homo sapiens Q6W2J9
TAP
27705803
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 13

PCH13

Pontocerebellar Hypoplasia Type 13

Pontocerebellar Hypoplasia 13

Doid:0112332

Hypoplasia, Pontocerebellar, Type 13
Microphthalmia, Syndromic 2

Oculofaciocardiodental Syndrome

Ofcd Syndrome

MCOPS2

Microphthalmia, Cataracts, Radiculomegaly, And Septal Heart Defects

Syndromic Microphthalmia 2

Anop2

Cataract-Microphthalmia-Radiculomegaly-Cardiac Septal Defect Syndrome

Maa2

Microphthalmia Cataracts Radiculomegaly And Septal Heart Defects

Syndromic Microphthalmia Type 2

Oculo-Facio-Cardio-Dental Syndrome

Anop2, Formerly

Maa2, Formerly

Microphthalmia Syndromic 2

Oculo Facio Cardio Dental Syndrome

Microphthalmia, Syndromic, 2

Marashi-Gorlin Syndrome

Microphthalmia, Cataracts, Radiculomegaly And Septal Heart Defects

Microphthalmia, Syndromic, Type 2
Syndromic Microphthalmia

Microphthalmia, Syndromic
Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma
Microphthalmia, Syndromic 1

MCOPS1

Lenz Microphthalmia Syndrome

Lenz Dysplasia

Mcops4

Syndromic Microphthalmia 1

Lenz Microphthalmia

Maa

Microphthalmia Or Anophthalmos With Associated Anomalies

Syndromic Microphthalmia Type 4

Microphthalmia, Syndromic 4

Microphthalmia, Syndromic 4, Formerly

Mcops4, Formerly

Anop1, Formerly

Maa, Formerly

Lenz Type Microphthalmia

Syndromic Microphthalmia 4

Microphthalmia Lenz Type

Microphthalmia Syndromic 1

Syndromic Microphthalmia Type 1

Microphthalmia Syndromic 4

Microphthalmia With Ankyloblepharon And Intellectual Disability

Microphthalmia, Lenz Type

Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome

Microphthalmia, Syndromic, 1

Anop1

Microphthalmia, Syndromic, Type 1
Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney

Childhood Kidney Clear Cell Sarcoma

Renal Clear Cell Sarcoma

Ccsk

Clear Cell Sarcoma Of The Kidney
Endometrial Stromal Sarcoma

Ess

Endometrial Stromal Sarcoma, High Grade

Undifferentiated Endometrial Sarcoma

Stromal Sarcoma Of The Corpus Uteri

Sarcoma Endometrial Stromal

Sarcoma, Endometrial Stromal

Undifferentiated Stromal Sarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10145 PCGF1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PCGF1 MGD MGI:1917087
Felis catus PCGF1 VGNC VGNC:81141
Canis familiaris PCGF1 VGNC VGNC:44300
Bos taurus PCGF1 VGNC VGNC:32626
Macaca mulatta PCGF1 VGNC VGNC:75640
Rattus norvegicus PCGF1 RGD RGD:1549782