2. Gene
  3. PCGF2 - polycomb group ring finger 2 Gene

PCGF2 - polycomb group ring finger 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TPFS; MEL-18; RNF110; ZNF144

Gene ID: 7703 | Gene type: protein coding

About PCGF2

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,733,898-38,749,792 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 180 orthologues, 7 paralogues and is associated with 3 phenotypes. Ubiquitous expression in kidney (RPKM 9.0), thyroid (RPKM 6.9) and 24 other tissues.

Summary

The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

PCGF2 Products(3)

mRNA Protein Name
NM_001369614.1 NP_001356543.1 polycomb group RING finger protein 2
NM_001369615.1 NP_001356544.1 polycomb group RING finger protein 2
NM_007144.3 NP_009075.1 polycomb group RING finger protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19636380 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
26151332 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19636380 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PRC1 complex IDA
IDA: Inferred from direct assay
19636380 GOA
part of PcG protein complex IDA
IDA: Inferred from direct assay
21282530 GOA
located in chromatin IDA
IDA: Inferred from direct assay
19636380 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21282530 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PCGF2 Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 56)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

polycomb group RING finger protein 2

DNA-binding protein Mel-18

PCGF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PCGF2 P35227 USP7 Homo sapiens Q93009
Pull Down
20601937
Intra
PCGF2 P35227 USP7 Homo sapiens Q93009
Anti Tag CoIP
20601937
Intra
PCGF2 P35227 USP7 Homo sapiens Q93009
TAP
20601937
Intra
PCGF2 P35227 USP11 Homo sapiens P51784
Anti Tag CoIP
20601937
Intra
PCGF2 P35227 USP11 Homo sapiens P51784
Pull Down
20601937
Intra
PCGF2 P35227 USP11 Homo sapiens P51784
TAP
20601937
Intra
PCGF2 P35227 UBC Homo sapiens P0CG48
Pull Down
20601937
Intra
PCGF2 P35227 UBC Homo sapiens P0CG48
TAP
20601937
Intra
PCGF2 P35227 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
PCGF2 P35227 CBX7 Homo sapiens O95931
Anti Tag CoIP
33961781
Intra
PCGF2 P35227 CBX7 Homo sapiens O95931
TAP
27705803
Intra
PCGF2 P35227 CBX7 Homo sapiens O95931
Anti Tag CoIP
28514442
Intra
PCGF2 P35227 CBX6 Homo sapiens O95503
Anti Tag CoIP
33961781
Intra
PCGF2 P35227 CBX6 Homo sapiens O95503
Anti Tag CoIP
28514442
Intra
PCGF2 P35227 CBX6 Homo sapiens O95503
TAP
27705803
Intra
PCGF2 P35227 PELI2 Homo sapiens Q9HAT8
Validated Y2H
32296183
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Bait CoIP
19636380
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
33961781
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
TAP
19636380
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
TAP
20601937
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
19636380
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
TAP
27705803
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Pull Down
21282530
Intra
PCGF2 P35227 CBX8 Homo sapiens Q9HC52
Anti Tag CoIP
28514442
Intra
PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
TAP
19636380
Intra
PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
TAP
27705803
Intra
PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
Anti Tag CoIP
33961781
Intra
PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
TAP
20601937
Intra
PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
Y2H Prey Pooling
25416956
Intra
PCGF2 P35227 PHC2 Homo sapiens Q8IXK0
Anti Bait CoIP
19636380
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Bait CoIP
19636380
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Tag CoIP
22493164
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
TAP
19636380
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
TAP
20601937
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Validated Y2H
32296183
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Tag CoIP
33961781
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Y2H Array
22493164
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Anti Tag CoIP
28514442
Intra
PCGF2 P35227 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra
PCGF2 P35227 PHC1 Homo sapiens P78364
TAP
19636380
Intra
PCGF2 P35227 PHC1 Homo sapiens P78364
Anti Tag CoIP
33961781
Intra
PCGF2 P35227 PHC1 Homo sapiens P78364
TAP
20601937
Intra
PCGF2 P35227 PHC1 Homo sapiens P78364
TAP
27705803
Intra
PCGF2 P35227 PHC1 Homo sapiens P78364
Anti Tag CoIP
28514442
Intra
PCGF2 P35227 PHC1 Homo sapiens P78364
Validated Y2H
32296183
Intra
PCGF2 P35227 RING1 Homo sapiens Q06587
Anti Tag CoIP
33961781
Intra
PCGF2 P35227 RING1 Homo sapiens Q06587
TAP
20601937
Intra
PCGF2 P35227 RING1 Homo sapiens Q06587
TAP
27705803
Intra
PCGF2 P35227 RING1 Homo sapiens Q06587
TAP
19636380
Intra
PCGF2 P35227 RING1 Homo sapiens Q06587
Validated Y2H
32296183
Intra
PCGF2 P35227 RING1 Homo sapiens Q06587
Y2H Array
22493164
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Turnpenny-Fry Syndrome

TPFS

Neurocardioskeletal Syndrome
Pontocerebellar Hypoplasia, Type 13

PCH13

Pontocerebellar Hypoplasia Type 13

Pontocerebellar Hypoplasia 13

Doid:0112332

Hypoplasia, Pontocerebellar, Type 13
Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10146 PCGF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCGF2 RGD RGD:1305097
Macaca mulatta PCGF2 VGNC VGNC:104640
Felis catus PCGF2 VGNC VGNC:64066
Mus musculus PCGF2 MGD MGI:99161
Canis familiaris PCGF2 VGNC VGNC:44301
Bos taurus PCGF2 VGNC VGNC:32627