Tlr2 - toll-like receptor 2 Gene

Mus musculus

Also known as Ly105

Gene ID: 24088 | Gene type: protein coding

About Tlr2

Chromosome 3: 83,743,579-83,749,074 reverse strand.GRCm39:CM000996.3

This gene has 1 transcript (splice variant), 248 orthologues, 23 paralogues and is associated with 114 phenotypes. Broad expression in lung adult (RPKM 3.8), bladder adult (RPKM 3.5) and 24 other tissues.

Summary

Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like Receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system Cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Tlr2 Products(1)

mRNA	Protein	Name
NM_011905.3	NP_036035.3	toll-like receptor 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IDA IDA: Inferred from direct assay	22198949	MGI
enables diacyl lipopeptide binding	IDA IDA: Inferred from direct assay	17889651	MGI
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	19931471	MGI
enables pattern recognition receptor activity	IMP IMP: Inferred from mutant phenotype	22033934	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16832055	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	22198949	MGI
enables triacyl lipopeptide binding	IDA IDA: Inferred from direct assay	17889651	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22033934	MGI
acts upstream of or within MyD88-dependent toll-like receptor signaling pathway	IGI IGI: Inferred from genetic interaction	12719478	MGI
acts upstream of or within cell surface pattern recognition receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12719478	MGI
acts upstream of or within cellular response to bacterial lipopeptide	IMP IMP: Inferred from mutant phenotype	15690042	MGI
acts upstream of or within cellular response to lipoteichoic acid	IMP IMP: Inferred from mutant phenotype	15690042	MGI
acts upstream of or within cellular response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	16949315	MGI
acts upstream of chemokine production	IMP IMP: Inferred from mutant phenotype	16239543	MGI
acts upstream of or within defense response	IMP IMP: Inferred from mutant phenotype	12091878	MGI
acts upstream of or within defense response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	11067888	MGI
acts upstream of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	16239543	MGI
acts upstream of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	10549626	MGI
involved in learning	IGI IGI: Inferred from genetic interaction	22198949	MGI
acts upstream of leukocyte migration	IMP IMP: Inferred from mutant phenotype	17114491	MGI
acts upstream of macrophage cytokine production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	10549626	MGI
involved in microglia development	IGI IGI: Inferred from genetic interaction	22198949	MGI
involved in negative regulation of actin filament polymerization	IGI IGI: Inferred from genetic interaction	22198949	MGI
acts upstream of or within negative regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	16949315	MGI
acts upstream of or within negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	16239543	MGI
involved in negative regulation of phagocytosis	IGI IGI: Inferred from genetic interaction	22198949	MGI
involved in negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	22198949	MGI
involved in negative regulation of synapse assembly	IGI IGI: Inferred from genetic interaction	22198949	MGI
acts upstream of neutrophil migration	IMP IMP: Inferred from mutant phenotype	17114491	MGI
acts upstream of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	10549626	MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22033934	MGI
acts upstream of or within positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	16239543	MGI
acts upstream of or within positive regulation of cytokine production	IGI IGI: Inferred from genetic interaction	19770268	MGI
involved in positive regulation of inflammatory response	IGI IGI: Inferred from genetic interaction	22198949	MGI
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	22198949	MGI
involved in positive regulation of interleukin-12 production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of interleukin-18 production	IDA IDA: Inferred from direct assay	15356140	MGI
acts upstream of or within positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	18261938	MGI
involved in positive regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	15356140	MGI
acts upstream of or within positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	10549626	MGI
involved in positive regulation of intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	22033934	MGI
acts upstream of or within positive regulation of leukocyte migration	IMP IMP: Inferred from mutant phenotype	17114491	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IDA IDA: Inferred from direct assay	18261938	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	10549626	MGI
acts upstream of or within positive regulation of neutrophil migration	IMP IMP: Inferred from mutant phenotype	17114491	MGI
acts upstream of or within positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	10549626	MGI
involved in positive regulation of nitric-oxide synthase biosynthetic process	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	15356140	MGI
involved in positive regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	22198949	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	10549626	MGI
acts upstream of or within positive regulation of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI
acts upstream of or within regulation of dendritic cell cytokine production	IDA IDA: Inferred from direct assay	19047410	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	17114491	MGI
acts upstream of or within response to molecule of fungal origin	IMP IMP: Inferred from mutant phenotype	12719478	MGI
acts upstream of or within response to peptidoglycan	IMP IMP: Inferred from mutant phenotype	10549626	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	10549626	MGI
acts upstream of xenophagy	IMP IMP: Inferred from mutant phenotype	22033934	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of Toll-like receptor 2-Toll-like receptor 6 protein complex	IPI IPI: Inferred from physical interaction	19931471	MGI
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	15220916	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12719478	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Tlr2 Protein Structure

LRR_1

PPP1R42

LRR_8

LRR_1

LRR_RI

PRK15370

LRR_RI

TPKR_C2

TIR

0
200
400
600
784 a.a.

Protein Preferred Names

Protein Names

toll-like receptor 2

Tlr2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Tlr2	Q9QUN7	Myd88	Mus musculus	P22366	Anti Bait CoIP	23994200
Intra	Tlr2	Q9QUN7	Myd88	Mus musculus	P22366	Anti Tag CoIP	16832055

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Tlr2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73590	TLR2 Protein, Mouse (sf9, His)	Q9QUN7 (M1-Q587)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100461	C29	Inhibitor	≥98.0%	Unkown
HY-P1180A	Pam3CSK4 TFA	Agonist	99.66%	Unkown
HY-123942	Diprovocim	Agonist	98.35%	Unkown
HY-108471	CU-CPT22	Inhibitor	≥99.0%	Unkown
HY-110353	CU-T12-9	Agonist	98.94%	Unkown
HY-112146	MMG-11	Antagonist	99.11%	Unkown
HY-116213	Sparstolonin B	Antagonist	99.54%	Unkown
HY-P2036A	FSL-1 TFA	Agonist	99.65%	Unkown
HY-N1346	Robinin	Inhibitor	98.77%	Unkown
HY-N2055	Kaempferol 3-O-sophoroside	Inhibitor	99.84%	Unkown
HY-18325	AN-3485	Inhibitor	95.63%	Unkown
HY-112146A	MMG-11 quarterhydrate	Antagonist	99.09%	Unkown
HY-150501	Diprovocim-X	Agonist	98.64%	Unkown
HY-P1180	Pam3CSK4	Agonist	/	Unkown
HY-P2036	FSL-1	Agonist	/	Unkown
HY-P2848A	Cholesterol oxidase, rhodococcus sp	Inhibitor	/	Unkown
HY-163829	TLR2 agonist 1	Agonist	/	Unkown
HY-P1405	Pam3CSK4-Biotin	Agonist	/	Unkown
HY-158058	WYJ-2	Agonist	/	Unkown
HY-14750	Rabeximod		/	Unkown
HY-P10586	Macrophage-activating lipopeptide 2	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tlr2	NCBI	NCBI:7097
Rattus norvegicus	Tlr2	NCBI	NCBI:310553

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