Eno1 - enolase 1 Gene

Rattus norvegicus

Also known as Nne

Gene ID: 24333 | Gene type: protein coding

About Eno1

Summary

Enables several functions, including heat shock protein binding activity; phosphopyruvate hydratase activity; and protein homodimerization activity. Involved in ERK1 and ERK2 cascade; canonical glycolysis; and cellular response to hypoxia. Located in several cellular components, including growth cone; membrane raft; and synaptic membrane. Part of phosphopyruvate hydratase complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (Enolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eno1 Products(2)

mRNA	Protein	Name
NM_001109908.1	NP_001103378.1	alpha-enolase
NM_012554.3	NP_036686.2	alpha-enolase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	14499952	RGD
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	21958194	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	7086434	RGD
enables phosphopyruvate hydratase activity	IDA IDA: Inferred from direct assay	7964722	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7964722	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	7964722	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	7086434	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	15459207	RGD
involved in canonical glycolysis	IDA IDA: Inferred from direct assay	15041191	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	15459207	RGD
involved in glycolytic process	IDA IDA: Inferred from direct assay	7964722	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	19433310	RGD
located in cell surface	IDA IDA: Inferred from direct assay	7964722	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	15459207	RGD
located in cytosol	IDA IDA: Inferred from direct assay	14499952	RGD
located in growth cone	IDA IDA: Inferred from direct assay	19433310	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	14499952	RGD
part of phosphopyruvate hydratase complex	IDA IDA: Inferred from direct assay	15041191	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	7964722	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	15041191	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-enolase

2-phospho-D-glycerate hydro-lyase	enolase 1, (alpha)
enolase 1, alpha non-neuron	non-neural enolase

Recombinant Eno1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75253	Enolase 1/ENO1 Protein, Rat (His)	Q5BJ93 (M1-K434)	≥95%

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108868	Mersalyl	Inducer	≥80.0%	Unkown

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131904	POMHEX		99.77%	Unkown
HY-117778	SF2312	Inhibitor	≥95.0%	Unkown
HY-131904A	Hex	Inhibitor	99.96%	Unkown
HY-117778B	SF2312 ammonium	Inhibitor	≥98.0%	Unkown
HY-102062	Nω-Propyl-L-arginine	Inhibitor	98.62%	Unkown
HY-102062A	Nω-Propyl-L-arginine hydrochloride	Inhibitor	98.28%	Unkown
HY-W003969	Aminopicoline	Inhibitor	99.96%	Unkown
HY-162168	Anti-inflammatory agent 71		/	Unkown
HY-RS04378	ENO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eno1	NCBI	NCBI:2023
Mus musculus	Eno1	NCBI	NCBI:13806

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