FRK - fyn related Src family tyrosine kinase Gene

Homo sapiens

Also known as GTK; RAK; PTK5

Gene ID: 2444 | Gene type: protein coding

About FRK

Cytogenetic location: 6q22.1 Genomic coordinates (GRCh38): 6:115,931,149-116,100,725 (from NCBI)

This gene has 1 transcript (splice variant), 217 orthologues and 32 paralogues. Broad expression in kidney (RPKM 3.0), duodenum (RPKM 2.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

FRK Products(1)

mRNA	Protein	Name
NM_002031.3	NP_002022.1	tyrosine-protein kinase FRK

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7664264	GOA
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	19345329	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	35723276	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12837246	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	7696183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase FRK

PTK5 protein tyrosine kinase 5

FRK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FRK	P42685	SF3B4	Homo sapiens	Q15427	Validated Y2H	25416956
Intra	FRK	P42685	SF3B4	Homo sapiens	Q15427	Y2H Array	25416956
Intra	FRK	P42685	RB1	Homo sapiens	P06400	Pull Down	7664264
Intra	FRK	P42685	RB1	Homo sapiens	P06400	Anti Bait CoIP	7664264
Intra	FRK	P42685	PTEN	Homo sapiens	P60484	Anti Bait CoIP	19345329
Intra	FRK	P42685	PTEN	Homo sapiens	P60484	Anti Tag CoIP	19345329
Intra	FRK	P42685	PTEN	Homo sapiens	P60484	Protein Kinase Assay	19345329
Intra	FRK	P42685	BNIP2	Homo sapiens	Q12982	Validated Y2H	32296183
Intra	FRK	P42685	BNIP2	Homo sapiens	Q12982	Y2H Prey Pooling	25416956
Intra	FRK	P42685	BNIP2	Homo sapiens	Q12982	Y2H	21516116
Intra	FRK	P42685	BNIP2	Homo sapiens	Q12982	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Liver Benign Neoplasm

Epithelial Hepatic And Intrahepatic Bile Duct Neoplasm

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05098	FRK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FRK	VGNC	VGNC:40978
Mus musculus	FRK	MGD	MGI:103265
Bos taurus	FRK	VGNC	VGNC:29112
Felis catus	FRK	VGNC	VGNC:62358
Rattus norvegicus	FRK	RGD	RGD:621423
Macaca mulatta	FRK	VGNC	VGNC:72818

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