Ngfr - nerve growth factor receptor Gene

Rattus norvegicus

Also known as p75; LNGFR; p75NTR; RNNGFRR; Tnfrsf16

Gene ID: 24596 | Gene type: protein coding

About Ngfr

Summary

Enables several functions, including amyloid-beta binding activity; nerve growth factor binding activity; and neurotrophin TrkA receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of neuron death; and regulation of neuron projection development. Located in several cellular components, including dendrite membrane; neuronal cell body membrane; and perikaryon. Used to study degenerative disc disease; glaucoma; hypertension; and middle cerebral artery infarction. Biomarker of several diseases, including brain disease (multiple); neuropathy (multiple); polycystic ovary syndrome; portal hypertension; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in Alzheimer's disease and mental depression. Orthologous to human NGFR (nerve growth factor receptor). [provided by Alliance of Genome Resources, Apr 2022]

Ngfr Products(1)

mRNA	Protein	Name
NM_012610.2	NP_036742.2	tumor necrosis factor receptor superfamily member 16 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	19334058	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	11756426	RGD
enables nerve growth factor binding	IDA IDA: Inferred from direct assay	3027580	RGD
enables neurotrophin TRKA receptor binding	IPI IPI: Inferred from physical interaction	9753156	RGD
enables neurotrophin binding	IPI IPI: Inferred from physical interaction	18596692	RGD
enables preprotein binding	IPI IPI: Inferred from physical interaction	20036257	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10485890	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23613963	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	19457114	RGD
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23920372	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23920372	RGD
involved in negative regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	22548193	RGD
involved in negative regulation of mitochondrial depolarization	IMP IMP: Inferred from mutant phenotype	19457114	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	11438587	RGD
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	18786176	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	12929129	RGD
involved in positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	18786176	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	21539892	RGD
involved in positive regulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	23114219	RGD
involved in positive regulation of myelination	IMP IMP: Inferred from mutant phenotype	12424382	RGD
involved in positive regulation of neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	23940017	RGD
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	23940017	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	22292018	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	19457114	RGD
involved in positive regulation of synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	18256260	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	18256260	RGD
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19457114	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	9267539	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	21084570	RGD
involved in skeletal muscle cell differentiation	IEP IEP: Inferred from expression pattern	16723531	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	1315318	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	17897318	RGD
located in dendrite membrane	IDA IDA: Inferred from direct assay	9521535	RGD
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	9521535	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	22138126	RGD
is active in neuromuscular junction	IDA IDA: Inferred from direct assay	20433604	RGD
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	9521535	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	9521535	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	9767155	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	20433604	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tumor necrosis factor receptor superfamily member 16

NGF receptor	gp80-LNGFR
low affinity nerve growth factor receptor	low affinity neurotrophin receptor p75NTR
nerve growth factor receptor (TNFR superfamily, member 16)	nerve growth factor receptor, fast
p75 ICD

Ngfr Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ngfr	P07174	NGF	Homo sapiens	P01138	X-Ray Diffraction	15131306
Intra	Ngfr	P07174	Ngf	Mus musculus	P01139	Solution Sedimentation	18596692
Cross	Ngfr	P07174	TRAF2	Homo sapiens	Q12933	Anti Tag CoIP	10514511
Cross	Ngfr	P07174	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	10514511
Intra	Ngfr	P07174	Ngfr	Rattus norvegicus	P07174	Crosslink	11756426
Intra	Ngfr	P07174	Ngfr	Rattus norvegicus	P07174	Solution Sedimentation	18596692
Cross	Ngfr	P07174	TRAF4	Homo sapiens	Q9BUZ4	Anti Tag CoIP	10514511
Cross	Ngfr	P07174	TRAF2	Homo sapiens	Q12933	Pull Down	10514511
Cross	Ngfr	P07174	TRAF6	Homo sapiens	Q9Y4K3	Anti Tag CoIP	21541365
Cross	Ngfr	P07174	P05067-PRO_0000000093	Homo sapiens	P05067-PRO_0000000093	Anti Bait CoIP	11756426
Intra	Ngfr	P07174	Ntrk1	Rattus norvegicus	P35739	Anti Bait CoIP	19549834

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111163	NSC49652	Inducer	99.92%	Unkown
HY-RS09278	NGFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ngfr	NCBI	NCBI:4804
Mus musculus	Ngfr	NCBI	NCBI:18053
Leporidae	Ngfr	NCBI

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