IL27 - interleukin 27 Gene

Homo sapiens

Also known as p28; IL30; IL-27; IL27A; IL-27A; IL27p28

Gene ID: 246778 | Gene type: protein coding

About IL27

Cytogenetic location: 16p12.1-p11.2 Genomic coordinates (GRCh38): 16:28,499,362-28,506,834 (from NCBI)

This gene has 2 transcripts (splice variants) and 88 orthologues. Biased expression in liver (RPKM 1.5), appendix (RPKM 0.4) and 6 other tissues.

Summary

The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR). [provided by RefSeq, Jul 2008]

IL27 Products(1)

mRNA	Protein	Name
NM_145659.3	NP_663634.2	interleukin-27 subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19933857	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	12734330	GOA
involved in regulation of T-helper 1 cell differentiation	IDA IDA: Inferred from direct assay	12734330	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interleukin-27 subunit alpha

IL-27 p28 subunit

IL27 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL27	Q8NEV9	CRLF1	Homo sapiens	O75462	Anti Tag CoIP	19933857
Intra	IL27	Q8NEV9	EBI3	Homo sapiens	Q14213	Anti Tag CoIP	20974977

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL27 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73199	IL-27 Protein, Human (CHO, His)	Q14213 (R21-K229)&Q8NEV9 (F29-P243)	≥95%
HY-P700122AF	Animal-Free IL-30/IL-27A Protein, Human (His)	Q8NEV9 (F29-P243)	≥95%

Related Diseases

Diseases

Alias

Toxoplasmosis

Disseminated Toxoplasmosis	Multisystemic Disseminated Toxoplasmosis
Acquired Toxoplasmosis	Toxoplasmosis Disease Or Disorder
Infection By Toxoplasma Gondii	Toxoplasmal
Toxoplasma

Autoimmune Disease Of Eyes, Ear, Nose And Throat

Autoimmune Uveitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990024	Casdozokitug	Inhibitor	96.49%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151508	Diamino lipid DAL4		/	Unkown
HY-RS06746	IL27 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06747	IL27RA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	IL27	VGNC	VGNC:62909
Rattus norvegicus	IL27	RGD	RGD:1561420
Canis familiaris	IL27	VGNC	VGNC:41976
Mus musculus	IL27	MGD	MGI:2384409
Macaca mulatta	IL27	VGNC	VGNC:99516
Bos taurus	IL27	VGNC	VGNC:30150
Others	IL27	NCBI

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