Vdr - vitamin D receptor Gene

Rattus norvegicus

Also known as Nr1i1

Gene ID: 24873 | Gene type: protein coding

About Vdr

Primary_assembly 7: 128,987,981-129,037,677 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 462 orthologues, 19 paralogues and is associated with 109 phenotypes. Biased expression in Kidney (RPKM 182.4), Lung (RPKM 16.2) and 3 other tissues.

Summary

Enables calcitriol binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of bone trabecula formation; and positive regulation of parathyroid hormone secretion. Located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Colocalizes with caveola. Used to study vitamin D-dependent rickets type 2A. Biomarker of secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vdr Products(1)

mRNA	Protein	Name
NM_017058.2	NP_058754.2	vitamin D3 receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcitriol binding	IDA IDA: Inferred from direct assay	8179318	RGD
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	9579411	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19074549	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16481392	RGD
enables vitamin D binding	IDA IDA: Inferred from direct assay	2829212	RGD
enables vitamin D binding	IMP IMP: Inferred from mutant phenotype	2829212	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	9579411	RGD
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	23752060	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	9753201	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	12107506	RGD
involved in negative regulation of bone trabecula formation	IMP IMP: Inferred from mutant phenotype	32231239	RGD
involved in negative regulation of ossification	IMP IMP: Inferred from mutant phenotype	32231239	RGD
involved in positive regulation of parathyroid hormone secretion	IMP IMP: Inferred from mutant phenotype	32231239	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	18353900	RGD
involved in response to aldosterone	IEP IEP: Inferred from expression pattern	29713904	RGD
involved in response to calcium ion	IEP IEP: Inferred from expression pattern	20181667	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10724336	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	20015453	RGD
located in caveola	IDA IDA: Inferred from direct assay	15272054	RGD
located in dense fibrillar component	IDA IDA: Inferred from direct assay	8392883	RGD
located in euchromatin	IDA IDA: Inferred from direct assay	8392883	RGD
located in heterochromatin	IDA IDA: Inferred from direct assay	8392883	RGD
located in nuclear matrix	IDA IDA: Inferred from direct assay	9744521	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9220147	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Vdr Protein Structure

NR_DBD_VDR

NR_LBD_VDR

0
100
200
300
400
423 a.a.

Protein Preferred Names

Protein Names

vitamin D3 receptor

1,25-dihydroxyvitamin D3 receptor	nuclear receptor subfamily 1 group I member 1
vitamin D (1,25- dihydroxyvitamin D3) receptor

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10002	Calcitriol	Agonist	99.94%	Unkown
HY-32351	Calcifediol		99.94%	Unkown
HY-10003	Alfacalcidol	Activator	99.96%	Unkown
HY-32339	Maxacalcitol	Activator	99.71%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-32344	Inecalcitol		97.42%	Phase 2
HY-32345	Elocalcitol	Agonist	99.2%	Phase 2
HY-14863	Lunacalcipol		/	Phase 2
HY-B1844	Flucythrinate		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147337	MeTC7	Antagonist	98.52%	Unkown
HY-32343	Secalciferol	Activator	99.89%	Unkown
HY-12398	TEI-9647	Agonist	99.88%	Unkown
HY-76814	Calcitriol-d6	Activator	99.06%	Unkown
HY-12407	ZK168281	Antagonist	≥98.0%	Unkown
HY-12398A	TEI-9648	Inhibitor	99.30%	Unkown
HY-12397	ZK159222	Antagonist	98.27%	Unkown
HY-103053	PS121912	Inhibitor	≥95.0%	Unkown
HY-15329	Maxacalcitol-d6	Activator	99.63%	Unkown
HY-10002A	(1S)-Calcitriol		98.94%	Unkown
HY-15332	Alfacalcidol-d6	Activator	≥98.0%	Unkown
HY-RS15632	VDR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-13294	Impurity C of Alfacalcidol	Activator	99.81%	Unkown
HY-15265	Impurity F of Calcipotriol	Activator	97.64%	Unkown
HY-13292	Impurity B of Calcitriol	Activator	98.04%	Unkown
HY-13293	Impurity C of Calcitriol	Activator	99.84%	Unkown
HY-75035	Calcipotriol Impurity C	Activator	99.20%	Unkown
HY-77278	25-Hydroxytachysterol3	Agonist	98.89%	Unkown
HY-131961	Triciferol		98.61%	Unkown
HY-15266	24R-Calcipotriol	Activator	/	Unkown
HY-75041	Calcitriol Impurities A	Activator	99.78%	Unkown
HY-77274	Calcitriol Impurities D	Activator	95.18%	Unkown
HY-15264	MC 1046	Activator	91.48%	Unkown
HY-114310	VDR agonist 1		/	Unkown
HY-10002S1	Calcitriol-d3		/	Unkown
HY-10003S	Alfacalcidol-d7	Activator	/	Unkown
HY-117182	LG190178		/	Unkown
HY-149899	VDR agonist 2	Agonist	/	Unkown
HY-161778	ZG-126		/	Unkown
HY-163947	UG-480	Modulator	/	Unkown
HY-32351AS	Calcifediol-d6 monohydrate		/	Unkown
HY-32351AS1	Calcifediol-13C5 monohydrate		/	Unkown
HY-RS15633	Vdr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS15634	Vdr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-10002S	Calcitriol-13C3	Inhibitor	≥97.0%	Unkown
HY-107218	11-Hydroxysugiol	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vdr	NCBI	NCBI:7421
Mus musculus	Vdr	NCBI	NCBI:22337

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