LTA - lymphotoxin alpha Gene

Rattus norvegicus

Also known as Tnfb

Gene ID: 25008 | Gene type: protein coding

About LTA

Primary_assembly 20: 3,618,853-3,620,859 forward strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 239 orthologues, 8 paralogues and is associated with 55 phenotypes. Biased expression in Spleen (RPKM 15.3), Thymus (RPKM 13.) and 1 other tissue.

Summary

Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Located in extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha). [provided by Alliance of Genome Resources, Apr 2022]

LTA Products(1)

mRNA	Protein	Name
NM_080769.2	NP_542947.1	lymphotoxin-alpha precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	1080770	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9798700	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	11595667	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15197744	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	12849708	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	12122042	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	20298761	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	1080770	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LTA Protein Structure

TNF

0
100
202 a.a.

Protein Preferred Names

Protein Names

lymphotoxin-alpha

LT-alpha	TNF-beta
lymphotoxin A	lymphotoxin alpha (TNF superfamily, member 1)
lymphotoxin-alpha-like	tumor necrosis factor beta
tumor necrosis factor ligand superfamily member 1

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0494	Bufexamac	Inhibitor	≥98.0%	Unkown

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99309	Pagibaximab	Inhibitor	98.81%	Phase 3

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103226	SC-57461A	Inhibitor	99.89%	Unkown
HY-W074890	Palmitoylglycine	Modulator	99.74%	Unkown
HY-135813	LtaS-IN-1	Inhibitor	95.05%	Unkown
HY-137298	LYS006	Inhibitor	98.61%	Unkown
HY-164051	1650-M15	Inhibitor	99.33%	Unkown
HY-113446S	Leukotriene C4-d5		97.9%	Unkown
HY-125770	5(S)-HPETE		≥98.0%	Unkown
HY-W004291	Methyl arachidate	Inhibitor	≥98.0%	Unkown
HY-10826	DG051 free acid	Inhibitor	/	Unkown
HY-112621	Leukotriene A4 methyl ester		/	Unkown
HY-118795	SC-22716	Inhibitor	/	Unkown
HY-130441	Leukotriene B3		/	Unkown
HY-146811	HSGN-94	Inhibitor	/	Unkown
HY-149801A	Antibacterial agent 140 chloride	Inhibitor	/	Unkown
HY-156960	JNJ-40929837	Inhibitor	/	Unkown
HY-156960A	JNJ-40929837 succinate	Inhibitor	/	Unkown
HY-160646	LTA4H-IN-3	Inhibitor	/	Unkown
HY-161349	LTA4H-IN-4	Inhibitor	/	Unkown
HY-162710	LTA4H-IN-5	Inhibitor	/	Unkown
HY-163336	14,15-Leukotriene A4 methyl ester		/	Unkown
HY-N8760	Batatasin IV	Inhibitor	/	Unkown
HY-RS07868	LTA Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07869	Lta Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07870	LTA Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07871	LTA4H Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W004291R	Methyl arachidate (Standard)	Inhibitor	/	Unkown
HY-10320A	Doramapimod hydrochloride	Inhibitor	/	Unkown
HY-129461	Dibenzyl trisulfide	Inducer	/	Unkown
HY-137298A	LYS006 hydrochloride	Inhibitor	/	Unkown
HY-156416	LtaS-IN-2	Inhibitor	/	Unkown
HY-162015	LTA4H-IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	LTA	NCBI	NCBI:4049
Canis familiaris	LTA	NCBI	NCBI:607183
Macaca fascicularis	LTA	NCBI	NCBI:102138497
Mus musculus	LTA	NCBI	NCBI:16992
Macaca mulatta	LTA	NCBI	NCBI:715425

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