Sstr4 - somatostatin receptor 4 Gene

Rattus norvegicus

Also known as Smstr4

Gene ID: 25555 | Gene type: protein coding

About Sstr4

Primary_assembly 3: 135,854,826-135,856,689 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 100 orthologues, 14 paralogues and is associated with 3 phenotypes.

Summary

Enables Somatostatin Receptor activity. Involved in several processes, including cellular response to glucocorticoid stimulus; positive regulation of arachidonic acid secretion; and regulation of signal transduction. Located in cytoplasm and plasma membrane. Biomarker of status epilepticus. Orthologous to human SSTR4 (Somatostatin Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Sstr4 Products(1)

mRNA	Protein	Name
NM_013036.3	NP_037168.1	somatostatin receptor type 4

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17950729	RGD
enables somatostatin receptor activity	IDA IDA: Inferred from direct assay	1362243	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IDA IDA: Inferred from direct assay	17945410	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	16534498	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	14512709	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	10805921	RGD
involved in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8175684	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	8175684	RGD
involved in positive regulation of arachidonate secretion	IDA IDA: Inferred from direct assay	8175684	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr4 Protein Structure

7tmA_SSTR4

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

somatostatin receptor type 4

SS-4-R	SS4-R
SS4R	Somatostatin receptor subtype 4 Rattus norvegicus Sprague-Dawley major hippocampal somatostatin receptor (SSTR4) mRNA

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105172	TT-232	Agonist	98.27%	Phase 2
HY-P0024	Veldoreotide	Activator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.21%	Unkown
HY-P4452	PRL 2915	Antagonist	99.57%	Unkown
HY-P3618	Cortistatin-29 (reduced)		98.12%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.37%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P2150	Cortistatin-29		/	Unkown
HY-139347	SSTR4 agonist-1	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sstr4	NCBI	NCBI:6754

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