PRL 2915

Name: PRL 2915
Brand: MedChemExpress
SKU: HY-P4452
Rating: 4.5 (1 reviews)

Cat. No.: HY-P4452 Purity: 99.57%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst₂) antagonist with a K_i of 12 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PRL 2915 Chemical Structure

CAS No. : 209006-18-8

Size	Price	Stock	Quantity
1 mg	USD 30	In-stock	Estimated Time of Arrival: April 21
5 mg	USD 60	In-stock	Estimated Time of Arrival: April 21
10 mg	USD 100	In-stock	Estimated Time of Arrival: April 21
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst₂) antagonist with a K_i of 12 nM^[1].

IC₅₀ & Target^[1]^[2]

hsst₂

12 nM (Ki)

hsst₃

100 nM (Ki)

hsst₅

520 nM (Ki)

hsst₁

>1000 nM (Ki)

hsst₂

1.8 nM (IC₅₀, rat antagonist bioassay versus somatostatin)

hsst₄

895 nM (Ki)

rat urotensin II receptor

293 nM (Ki)

human urotensin II receptor

562 nM (Ki)

In Vitro

PRL 2915 (0.3-30 nM; 30 min) dose-dependently blocks the development of human urotensin II-induced tonic contractions of rat aortic rings^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1175.85

Formula

C₅₉H₇₁ClN₁₂O₈S₂

CAS No.

209006-18-8

Appearance

Solid

Color

White to off-white

Sequence

{Phe<4-Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-Lys-{Val<3-Me>}-Cys-{2-Nal}-NH2(Disulfide bond)

Sequence Shortening

{F<4-Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-K-{V<3-Me>}-C-{A<3(2-Naph)>}-NH2 (Disulfide bridge:Cys2-Cys7)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (85.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8504 mL	4.2522 mL	8.5045 mL
5 mM	0.1701 mL	0.8504 mL	1.7009 mL
10 mM	0.0850 mL	0.4252 mL	0.8504 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (2.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (2.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (281 KB) SDS (252 KB)

COA (259 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Hocart SJ, et al. Highly potent cyclic disulfide antagonists of somatostatin. J Med Chem. 1999 Jun 3;42(11):1863-71. [Content Brief]

[2]. Rossowski WJ, et al. Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists. Eur J Pharmacol. 2002 Mar 8;438(3):159-70. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8504 mL	4.2522 mL	8.5045 mL	21.2612 mL
	5 mM	0.1701 mL	0.8504 mL	1.7009 mL	4.2522 mL
	10 mM	0.0850 mL	0.4252 mL	0.8504 mL	2.1261 mL
	15 mM	0.0567 mL	0.2835 mL	0.5670 mL	1.4174 mL
	20 mM	0.0425 mL	0.2126 mL	0.4252 mL	1.0631 mL
	25 mM	0.0340 mL	0.1701 mL	0.3402 mL	0.8504 mL
	30 mM	0.0283 mL	0.1417 mL	0.2835 mL	0.7087 mL
	40 mM	0.0213 mL	0.1063 mL	0.2126 mL	0.5315 mL
	50 mM	0.0170 mL	0.0850 mL	0.1701 mL	0.4252 mL
	60 mM	0.0142 mL	0.0709 mL	0.1417 mL	0.3544 mL
	80 mM	0.0106 mL	0.0532 mL	0.1063 mL	0.2658 mL

PRL 2915 Related Classifications

Endocrinology

Keywords:

PRL 2915209006-18-8PRL2915PRL-2915Somatostatin ReceptorUrotensin ReceptorSSTRsSSTRUT receptorInhibitorinhibitorinhibit

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PRL 2915

Customer Review

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•Related Screening Libraries:

View All Somatostatin Receptor Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

PRL 2915 Related Classifications

Keywords:

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