2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor Urotensin Receptor
  4. PRL 2915

PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PRL 2915 Chemical Structure

PRL 2915 Chemical Structure

CAS No. : 209006-18-8

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5 mg USD 280 In-stock
10 mg USD 420 In-stock
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Based on 1 publication(s) in Google Scholar

PRL 2915 Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM[1].

IC50 & Target[1][2]

hsst2

12 nM (Ki)

hsst3

100 nM (Ki)

hsst5

520 nM (Ki)

hsst4

895 nM (Ki)

hsst1

>1000 nM (Ki)

hsst2

1.8 nM (IC50, rat antagonist bioassay versus somatostatin)

rat urotensin II receptor

293 nM (Ki)

human urotensin II receptor

562 nM (Ki)

In Vitro

PRL 2915 (0.3-30 nM; 30 min) dose-dependently blocks the development of human urotensin II-induced tonic contractions of rat aortic rings[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PRL 2915 Related Antibodies
Molecular Weight

1175.85

Formula

C59H71ClN12O8S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Phe<4-Cl>}-{d-Cys}-{β-Ala<3-Py>}-{d-Trp}-Lys-{Val<3-Me>}-Cys-{2-Nal}-NH2(Disulfide bond)
Sequence Shortening

{F<4-Cl>}-{d-C}-{β-A<3-Py>}-{d-W}-K-{V<3-Me>}-C-{A<3(2-Naph)>}-NH2 (Disulfide bridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (85.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8504 mL 4.2522 mL 8.5045 mL
5 mM 0.1701 mL 0.8504 mL 1.7009 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.57%

SDS (252 KB)

COA (259 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8504 mL 4.2522 mL 8.5045 mL 21.2612 mL
5 mM 0.1701 mL 0.8504 mL 1.7009 mL 4.2522 mL
10 mM 0.0850 mL 0.4252 mL 0.8504 mL 2.1261 mL
15 mM 0.0567 mL 0.2835 mL 0.5670 mL 1.4174 mL
20 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0631 mL
25 mM 0.0340 mL 0.1701 mL 0.3402 mL 0.8504 mL
30 mM 0.0283 mL 0.1417 mL 0.2835 mL 0.7087 mL
40 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5315 mL
50 mM 0.0170 mL 0.0850 mL 0.1701 mL 0.4252 mL
60 mM 0.0142 mL 0.0709 mL 0.1417 mL 0.3544 mL
80 mM 0.0106 mL 0.0532 mL 0.1063 mL 0.2658 mL
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PRL 2915 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PRL 2915209006-18-8PRL2915PRL-2915Somatostatin ReceptorUrotensin ReceptorSSTRsSSTRUT receptorInhibitorinhibitorinhibit

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