2. GPCR/G Protein Neuronal Signaling
  3. Somatostatin Receptor
  4. Veldoreotide TFA

Veldoreotide TFA  (Synonyms: DG3173 TFA; PTR-3173 TFA)

Cat. No.: HY-P0024A Purity: 98.37%
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Veldoreotide (DG3173) TFA a somatostatin analogue, binds to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide TFA inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent

For research use only. We do not sell to patients.

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Veldoreotide TFA Chemical Structure

Veldoreotide TFA Chemical Structure

CAS No. : 2126831-23-8

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5 mg USD 610 In-stock
10 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

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Veldoreotide TFA Related Antibodies

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SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

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Description

Veldoreotide (DG3173) TFA a somatostatin analogue, binds to and activate the somatostatin receptors (SSTR) 2, 4, and 5. Veldoreotide TFA inhibits growth hormone (GH) secretion in adenomas compared with Octreotide (HY-P0036). Veldoreotide has the potential to be used as pain modulating agent[1]

IC50 & Target[1]

SSTR2

37.6 nM (EC50)

SSTR3

31.3 nM (EC50)

SSTR4

10.5 nM (EC50)

In Vitro

Veldoreotide stimulates the SST2, SST4, and SST5 receptors with high potency and efficacy in the HEK293 cells, co-expressing these receptors with the GIRK2 channels; EC50s of 37.6 ± 4.5 nM, 31.3 ± 14.4 nM and 10.5 ± 3.4 nM for GIRK2-SST2, GIRK2-SST4 and GIRK2-SST5, respectively[1].
Veldoreotide (10 μM; 24 h) inhibits SST4-expressing BON-1 cells[1].
Veldoreotide (DG3173) (100 nM or 1 μM; 6 h) inhibits GH secreation in adenomas with an IC50 of 0.49 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Veldoreotide TFA Related Antibodies

Cell Viability Assay[1]

Cell Line: SST4-expressing BON-1 cells.
Concentration: 10 μM.
Incubation Time: 24 h.
Result: Inhibited SST4-expressing BON-1 cells, while did not significantly inhibited wild type BON-1 cells.
Molecular Weight

1237.33

Formula

C62H75F3N12O12
CAS No.
Appearance

Solid

Color

White to off-white

Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 25 mg/mL (20.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8082 mL 4.0410 mL 8.0819 mL
5 mM 0.1616 mL 0.8082 mL 1.6164 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8082 mL 4.0410 mL 8.0819 mL 20.2048 mL
5 mM 0.1616 mL 0.8082 mL 1.6164 mL 4.0410 mL
10 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0205 mL
15 mM 0.0539 mL 0.2694 mL 0.5388 mL 1.3470 mL
20 mM 0.0404 mL 0.2020 mL 0.4041 mL 1.0102 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Veldoreotide TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Veldoreotide2126831-23-8DG3173PTR-3173DG 3173DG-3173PTR3173PTR 3173Somatostatin ReceptorSSTRsSSTRsomatostatingrowth hormonepainInhibitorinhibitorinhibit

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