Cd28 - Cd28 molecule Gene

Rattus norvegicus

Also known as CD28RNA

Gene ID: 25660 | Gene type: protein coding

About Cd28

Primary_assembly 9: 62,166,192-62,194,685 forward strand.mRatBN7.2:CM026982.1

This gene has 3 transcripts (splice variants), 132 orthologues, 1 paralogue and is associated with 34 phenotypes. Biased expression in Thymus (RPKM 29.4), Spleen (RPKM 42.9) and 4 other tissues.

Summary

Enables identical protein binding activity. Involved in T cell activation and T cell costimulation. Located in membrane raft. Used to study lymphopenia. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd28 Products(1)

mRNA	Protein	Name
NM_013121.2	NP_037253.2	T-cell-specific surface glycoprotein CD28 precursor

Cd28 Protein Structure

0
100
200
218 a.a.

Protein Preferred Names

Protein Names

T-cell-specific surface glycoprotein CD28

CD28 antigen

Recombinant Cd28 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74309	CD28 Protein, Rat (HEK293, His)	P31042 (N20-K149)	≥95%
HY-P74310	CD28 Protein, Rat (HEK293, Fc)	P31042/EDL98926.1 (N20-K149)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1698B	Reltecimod TFA	Chemical	99.78%	Phase 3
HY-P1698	Reltecimod	Antagonist	99.88%	Phase 3

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99961	Tifcemalimab	Inhibitor	95.00%	Phase 3
HY-P99293	Galiximab	Inhibitor	99.23%	Phase 3
HY-P99302	Lulizumab	Inhibitor	≥95.0%	Phase 2
HY-P99420	Acazicolcept	Antagonist	99.27%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Purity	Rare Diseases
HY-102090	B7/CD28 interaction inhibitor 1	99.47%	Unkown
HY-100891	CD80-IN-3	98.08%	Unkown
HY-N10445	Maydispenoid A	/	Unkown
HY-162810	ICOS-IN-1	/	Unkown
HY-N10446	Maydispenoid B	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9975	Theralizumab	Agonist	97.21%	Unkown
HY-P99123	Anti-Mouse CD28 Antibody (37.51)		≥95.0%	Unkown
HY-P990752	Nezastomig		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd28	NCBI	NCBI:940
Canis familiaris	Cd28	NCBI	NCBI:403646
Macaca fascicularis	Cd28	NCBI	NCBI:102146670
Mus musculus	Cd28	NCBI	NCBI:12487
Macaca mulatta	Cd28	NCBI	NCBI:705313

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