2. Anti-infection Immunology/Inflammation
  3. Bacterial CD28
  4. Reltecimod

Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Reltecimod Chemical Structure

Reltecimod Chemical Structure

CAS No. : 1447799-33-8

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10 mg USD 65 In-stock
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Based on 1 publication(s) in Google Scholar

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Reltecimod Related Antibodies

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Description

Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs)[1][2].

IC50 & Target

TP44, Bacteria[1][2]
In Vivo

Reltecimod (1.25-5 mg/kg; i.v.) increases the survival rate of mice infected with different bacteria[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free, female BALB/c mice (Acute bacterial peritonitis was induced by i.p. administration with E. coli 018:K1)[2]
Dosage: 1.25 or 5 mg/kg
Administration: i.v.; single dosage; at 4 h post infection
Result: Resulted in 100% survival at single dosage of 5 mg/kg, at day 6.
Resulted in 70% survival at 4 dosage (at 1, 12, 24 and 36 h post infection) of 1.25 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice (NSTI induced by thigh i.m. administration with Streptococcus pyogenes)[2]
Dosage: 2.5 or 5 mg/kg
Administration: i.v.; single dosage; at 1 h, or at 1 h and 12 or 72 h post infection
Result: Resulted in 65% survival at single dosage of 2.5 mg/kg, at day 8.
Resulted in 30% survival at two dosage (1 and 12 h post infection) of 2.5 mg/kg, at day 8.
Resulted in 90% survival at single dosage (1 h post infection) of 5 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice [Cecal ligation and puncture (CLP) model][2]
Dosage: 1.25, 2.5, or 5 mg/kg
Administration: i.v.; single dosage
Result: Increased day 7 survival by up to 100%.
Clinical Trial
Molecular Weight

1037.19

Formula

C46H72N10O15S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

ASPMLVAYDA
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (96.41 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9641 mL 4.8207 mL 9.6414 mL
5 mM 0.1928 mL 0.9641 mL 1.9283 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9641 mL 4.8207 mL 9.6414 mL 24.1036 mL
5 mM 0.1928 mL 0.9641 mL 1.9283 mL 4.8207 mL
10 mM 0.0964 mL 0.4821 mL 0.9641 mL 2.4104 mL
15 mM 0.0643 mL 0.3214 mL 0.6428 mL 1.6069 mL
20 mM 0.0482 mL 0.2410 mL 0.4821 mL 1.2052 mL
25 mM 0.0386 mL 0.1928 mL 0.3857 mL 0.9641 mL
30 mM 0.0321 mL 0.1607 mL 0.3214 mL 0.8035 mL
40 mM 0.0241 mL 0.1205 mL 0.2410 mL 0.6026 mL
50 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4821 mL
60 mM 0.0161 mL 0.0803 mL 0.1607 mL 0.4017 mL
80 mM 0.0121 mL 0.0603 mL 0.1205 mL 0.3013 mL
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Reltecimod Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reltecimod1447799-33-8AB-103AB103AB 103BacterialCD28NSTIsTP44T cellE. coliStreptococcus pyogenesCecal ligation and punctureCLPInhibitorinhibitorinhibit

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