Cd28 - CD28 antigen Gene

Mus musculus

Gene ID: 12487 | Gene type: protein coding

About Cd28

Chromosome 1: 60,755,959-60,812,518 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 132 orthologues, 1 paralogue and is associated with 47 phenotypes. Biased expression in thymus adult (RPKM 17.9), spleen adult (RPKM 1.8) and 1 other tissue.

Summary

Enables protein kinase binding activity. Acts upstream of or within several processes, including positive regulation of immune response; positive regulation of intracellular signal transduction; and regulation of lymphocyte activation. Located in external side of plasma membrane and immunological synapse. Human ortholog(s) of this gene implicated in multiple sclerosis and type 1 diabetes mellitus. Orthologous to human CD28 (CD28 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd28 Products(2)

mRNA	Protein	Name
NM_007642.4	NP_031668.3	T-cell-specific surface glycoprotein CD28 precursor
NM_007642.4	NP_031668.3	T-cell-specific surface glycoprotein CD28 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21245484	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	8125140	MGI
acts upstream of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	9368605	MGI
acts upstream of or within T cell costimulation	IDA IDA: Inferred from direct assay	8125140	MGI
acts upstream of or within T cell costimulation	IGI IGI: Inferred from genetic interaction	23793062	MGI
acts upstream of or within T cell costimulation	IMP IMP: Inferred from mutant phenotype	7688139	MGI
acts upstream of T cell proliferation	IDA IDA: Inferred from direct assay	12925852	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	7688139	MGI
acts upstream of or within T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23793062	MGI
acts upstream of or within apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10429671	MGI
acts upstream of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	7688139	MGI
acts upstream of or within negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	10429671	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	23589618	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	8125140	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell proliferation	IMP IMP: Inferred from mutant phenotype	9368605	MGI
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	12867038	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	7688139	MGI
acts upstream of or within positive regulation of inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	10791997	MGI
acts upstream of or within positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	7688139	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IMP IMP: Inferred from mutant phenotype	7688139	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	23589618	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16809611	MGI
acts upstream of or within regulation of regulatory T cell differentiation	IGI IGI: Inferred from genetic interaction	21245484	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16809611	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	7790813	MGI
located in external side of plasma membrane	IMP IMP: Inferred from mutant phenotype	7688139	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	23793062	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cd28 Protein Structure

0
100
200
218 a.a.

Protein Preferred Names

Protein Names

T-cell-specific surface glycoprotein CD28

Recombinant Cd28 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70614	CD28 Protein, Mouse (HEK293, Fc-His)	P31041 (N20-K149)	≥95%
HY-P74311	CD28 Protein, Mouse (Biotinylated , HEK293, His)	P31041 (N20-K149)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1698	Reltecimod	Antagonist	99.88%	Phase 3
HY-P1698B	Reltecimod TFA	Chemical	99.78%	Phase 3

Inhibitory Antibodies (7)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P9986	Tiragolumab	Inhibitor	99.04%	Phase 3
HY-P99961	Tifcemalimab	Inhibitor	95.00%	Phase 3
HY-P99293	Galiximab	Inhibitor	99.23%	Phase 3
HY-P99302	Lulizumab	Inhibitor	≥95.0%	Phase 2
HY-P99414	Prezalumab	Inhibitor	99.23%	Phase 2
HY-P99420	Acazicolcept	Antagonist	99.27%	Phase 2
HY-P99431	KY-1044		99.51%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-102090	B7/CD28 interaction inhibitor 1		99.47%	Unkown
HY-100891	CD80-IN-3		98.08%	Unkown
HY-N10445	Maydispenoid A		/	Unkown
HY-162810	ICOS-IN-1		/	Unkown
HY-N10446	Maydispenoid B		/	Unkown
HY-169819	Calcium influx inducer compound 634	Activator	/	Unkown

Inhibitory Antibodies (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9975	Theralizumab	Agonist	99.46%	Unkown
HY-P99123	Anti-Mouse CD28 Antibody (37.51)		≥95.0%	Unkown
HY-P990773	Venanprubart	Inhibitor	98.00%	Unkown
HY-P991038	Zadoprubart		/	Unkown
HY-P990938	Pegrizeprument		/	Unkown
HY-P990236	Anti-Mouse/Rat/Monkey/Human ICOS/CD278 Antibody (C398.4A)		/	Unkown
HY-P990819	Anti-Rat CD28 Antibody (JJ316)	Inhibitor	/	Unkown
HY-P990752	Nezastomig		/	Unkown
HY-P990793	Anti-Mouse CD28 Antibody (D665)	Inhibitor	/	Unkown
HY-P990865	Anti-CD28 Antibody (9.3)	Inhibitor	/	Unkown
HY-P990079	Renvistobart	Inhibitor	/	Unkown
HY-P99893	Rozibafusp alfa	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd28	NCBI	NCBI:940
Canis familiaris	Cd28	NCBI	NCBI:403646
Macaca fascicularis	Cd28	NCBI	NCBI:102146670
Rattus norvegicus	Cd28	NCBI	NCBI:25660
Macaca mulatta	Cd28	NCBI	NCBI:705313

Name
Email *

	Sorry, but the email address you supplied was invalid.