Dnm2 - dynamin 2 Gene

Rattus norvegicus

Also known as DYIIAAB

Gene ID: 25751 | Gene type: protein coding

About Dnm2

Summary

Enables several functions, including D2 Dopamine Receptor binding activity; Enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including positive regulation of transport; regulation of plasma membrane bounded cell projection assembly; and regulation of signal transduction. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and ruffle membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Colocalizes with growth cone. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate B; centronuclear myopathy 1; and lethal congenital contracture syndrome. Orthologous to human DNM2 (Dynamin 2). [provided by Alliance of Genome Resources, Apr 2022]

Dnm2 Products(1)

mRNA	Protein	Name
NM_013199.2	NP_037331.1	dynamin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D2 dopamine receptor binding	IPI IPI: Inferred from physical interaction	14709338	RGD
enables GTPase activity	IDA IDA: Inferred from direct assay	16325581	RGD
enables SH3 domain binding	IPI IPI: Inferred from physical interaction	19122684	RGD
enables WW domain binding	IPI IPI: Inferred from physical interaction	23994472	RGD
enables nitric-oxide synthase binding	IDA IDA: Inferred from direct assay	21490139	RGD
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: Inferred from direct assay	12205083	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11583995	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15007081	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	20802490	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17257598	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor internalization	IMP IMP: Inferred from mutant phenotype	14709338	RGD
involved in Golgi to plasma membrane transport	IMP IMP: Inferred from mutant phenotype	20231454	RGD
involved in actin filament bundle organization	IMP IMP: Inferred from mutant phenotype	19605363	RGD
involved in cellular response to X-ray	IEP IEP: Inferred from expression pattern	15994918	RGD
involved in cellular response to carbon monoxide	IEP IEP: Inferred from expression pattern	25100282	RGD
involved in cellular response to dopamine	IDA IDA: Inferred from direct assay	12205083	RGD
involved in cellular response to nitric oxide	IEP IEP: Inferred from expression pattern	25100282	RGD
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	15048127	RGD
involved in macropinocytosis	IMP IMP: Inferred from mutant phenotype	18003703	RGD
involved in membrane tubulation	IMP IMP: Inferred from mutant phenotype	35620056	RGD
involved in negative regulation of non-motile cilium assembly	IMP IMP: Inferred from mutant phenotype	23994472	RGD
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25100282	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	21210813	RGD
involved in positive regulation of P-type sodium:potassium-exchanging transporter activity	IMP IMP: Inferred from mutant phenotype	12205083	RGD
involved in positive regulation of clathrin-dependent endocytosis	IMP IMP: Inferred from mutant phenotype	11925437	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	18435821	RGD
involved in positive regulation of lamellipodium assembly	IMP IMP: Inferred from mutant phenotype	14617821	RGD
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	16973909	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	12802072	RGD
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	14617821	RGD
involved in postsynaptic endocytosis	EXP EXP: Inferred from Experiment	31597090	RGD
involved in postsynaptic endocytosis	IDA IDA: Inferred from direct assay	31597090	RGD
involved in postsynaptic endocytosis	IMP IMP: Inferred from mutant phenotype	31597090	RGD
involved in protein polymerization	IMP IMP: Inferred from mutant phenotype	35620056	RGD
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	11925437	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	19995918	RGD
involved in regulation of Golgi organization	IMP IMP: Inferred from mutant phenotype	20231454	RGD
involved in regulation of Rac protein signal transduction	IMP IMP: Inferred from mutant phenotype	14617821	RGD
involved in regulation of axon extension	IMP IMP: Inferred from mutant phenotype	21210813	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	19562697	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	22666495	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	12199526	RGD
involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	35620056	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	15821732	RGD
located in cell junction	IDA IDA: Inferred from direct assay	21210813	RGD
located in centrosome	IDA IDA: Inferred from direct assay	15048127	RGD
located in clathrin-coated endocytic vesicle	IDA IDA: Inferred from direct assay	11925437	RGD
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	9725914	RGD
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	9438853	RGD
located in endosome	IDA IDA: Inferred from direct assay	12802072	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	31597090	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11583995	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	11583995	RGD
located in growth cone	IDA IDA: Inferred from direct assay	21210813	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	9725914	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	11583995	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15126636	RGD
located in phagocytic cup	IDA IDA: Inferred from direct assay	12802072	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	11583995	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	11583995	RGD
is active in postsynaptic density, intracellular component	IMP IMP: Inferred from mutant phenotype	11583995	RGD
is active in postsynaptic endocytic zone	IDA IDA: Inferred from direct assay	35072626	RGD
is active in postsynaptic endocytic zone	IMP IMP: Inferred from mutant phenotype	35072626	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17257598	RGD
located in ruffle membrane	IDA IDA: Inferred from direct assay	9725914	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	12802072	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dynamin-2

Dnm2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Dnm2	P39052	SH3BP4	Homo sapiens	Q9P0V3	SPR	16325581
Cross	Dnm2	P39052	SH3BP4	Homo sapiens	Q9P0V3	Pull Down	16325581
Cross	Dnm2	P39052	SH3KBP1	Homo sapiens	Q96B97	Pull Down	20711168
Cross	Dnm2	P39052	SORBS1	Homo sapiens	Q9BX66	Pull Down	19116150
Intra	Dnm2	P39052	Shank1	Rattus norvegicus	Q9WV48	Anti Tag CoIP	11583995
Intra	Dnm2	P39052	Shank1	Rattus norvegicus	Q9WV48	Anti Bait CoIP	11583995

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132583	IONIS-DNM2-2.5Rx	Inhibitor	/	Unkown
HY-132583A	IONIS-DNM2-2.5Rx sodium	Inhibitor	/	Unkown
HY-RS03905	DNM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnm2	NCBI	NCBI:1785

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