TNFAIP8 - TNF alpha induced protein 8 Gene

Homo sapiens

Also known as NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13

Gene ID: 25816 | Gene type: protein coding

About TNFAIP8

Cytogenetic location: 5q23.1 Genomic coordinates (GRCh38): 5:119,268,759-119,399,688 (from NCBI)

This gene has 7 transcripts (splice variants), 131 orthologues and 3 paralogues. Broad expression in lymph node (RPKM 31.1), fat (RPKM 24.0) and 19 other tissues.

Summary

Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in positive regulation of apoptotic process. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNFAIP8 Products(6)

mRNA	Protein	Name
NM_001077654.3	NP_001071122.1	tumor necrosis factor alpha-induced protein 8 isoform b
NM_001286813.2	NP_001273742.1	tumor necrosis factor alpha-induced protein 8 isoform a
NM_001286814.1	NP_001273743.1	tumor necrosis factor alpha-induced protein 8 isoform c
NM_001286815.2	NP_001273744.1	tumor necrosis factor alpha-induced protein 8 isoform d
NM_001286817.2	NP_001273746.1	tumor necrosis factor alpha-induced protein 8 isoform d
NM_014350.4	NP_055165.2	tumor necrosis factor alpha-induced protein 8 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	10644768	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	10644768	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14724590	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP8 Protein Structure

DUF758

0
100
198 a.a.

Protein Preferred Names

Protein Names

tumor necrosis factor alpha-induced protein 8

NF-kappa-B-inducible DED-containing protein

TNFAIP8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNFAIP8	O95379	ATN1	Homo sapiens	Q86V38	Y2H Prey Pooling	32296183
Intra	TNFAIP8	O95379	ATN1	Homo sapiens	Q86V38	Validated Y2H	32296183
Intra	TNFAIP8	O95379	ATN1	Homo sapiens	Q86V38	Y2H Array	32296183
Intra	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Pooling	16189514
Intra	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	25416956
Intra	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	25416956
Intra	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Prey Pooling	32296183
Intra	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Validated Y2H	32296183
Intra	TNFAIP8	O95379	MED4	Homo sapiens	Q9NPJ6	Y2H Array	32296183
Intra	TNFAIP8	O95379	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	TNFAIP8	O95379	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	TNFAIP8	O95379	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183
Intra	TNFAIP8	O95379	TIFA	Homo sapiens	Q96CG3	Validated Y2H	25416956
Intra	TNFAIP8	O95379	TIFA	Homo sapiens	Q96CG3	Y2H Array	25416956
Intra	TNFAIP8	O95379	PRR13	Homo sapiens	Q9NZ81	Y2H Prey Pooling	25416956
Intra	TNFAIP8	O95379	PRR13	Homo sapiens	Q9NZ81	Validated Y2H	32296183
Intra	TNFAIP8	O95379	PRR13	Homo sapiens	Q9NZ81	Y2H Array	25416956
Intra	TNFAIP8	O95379	PLEKHF1	Homo sapiens	Q96S99	Validated Y2H	32296183
Intra	TNFAIP8	O95379	PLEKHF1	Homo sapiens	Q96S99	Y2H Prey Pooling	32296183
Intra	TNFAIP8	O95379	PLEKHF1	Homo sapiens	Q96S99	Y2H Array	32296183
Intra	TNFAIP8	O95379	EAPP	Homo sapiens	Q56P03	Validated Y2H	32296183
Intra	TNFAIP8	O95379	EAPP	Homo sapiens	Q56P03	Y2H Array	32296183
Intra	TNFAIP8	O95379	EAPP	Homo sapiens	Q56P03	Y2H Prey Pooling	32296183
Intra	TNFAIP8	O95379	EAF1	Homo sapiens	Q96JC9	Validated Y2H	32296183
Intra	TNFAIP8	O95379	INO80E	Homo sapiens	Q8NBZ0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFAIP8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76682	TNFAIP8 Protein, Human (His)	O95379-1 (M1-I198)	≥95%

TNFAIP8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81855	TNFAIP8 Antibody (YA1600)	WB, IP	Human

Related Diseases

Diseases

Alias

Plantar Fasciitis

Fasciitis, Plantar

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14791	TNFAIP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14792	TNFAIP8L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14793	TNFAIP8L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14794	TNFAIP8L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNFAIP8	RGD	RGD:1305908
Felis catus	TNFAIP8	VGNC	VGNC:102349
Bos taurus	TNFAIP8	VGNC	VGNC:36157
Mus musculus	TNFAIP8	MGD	MGI:2147191
Macaca mulatta	TNFAIP8	VGNC	VGNC:79068
Canis familiaris	TNFAIP8	VGNC	VGNC:47652
Others	TNFAIP8	NCBI

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