SERBP1 - SERPINE1 mRNA binding protein 1 Gene

Homo sapiens

Also known as CGI-55; CHD3IP; HABP4L; PAIRBP1; PAI-RBP1

Gene ID: 26135 | Gene type: protein coding

About SERBP1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,407,810-67,430,402 (from NCBI)

This gene has 8 transcripts (splice variants), 282 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 40.3), thyroid (RPKM 34.9) and 25 other tissues.

Summary

Enables SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SERBP1 Products(4)

mRNA	Protein	Name
NM_001018067.2	NP_001018077.1	plasminogen activator inhibitor 1 RNA-binding protein isoform 1
NM_001018068.2	NP_001018078.1	plasminogen activator inhibitor 1 RNA-binding protein isoform 2
NM_001018069.2	NP_001018079.1	plasminogen activator inhibitor 1 RNA-binding protein isoform 3
NM_015640.4	NP_056455.3	plasminogen activator inhibitor 1 RNA-binding protein isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	EXP EXP: Inferred from Experiment	34631798	GOA
enables SUMO binding	IDA IDA: Inferred from direct assay	28695742	GOA
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	11001948	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12505151	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	23636399	GOA
enables translation repressor activity	IDA IDA: Inferred from direct assay	36691768	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in PML body organization	IDA IDA: Inferred from direct assay	28695742	GOA
involved in negative regulation of translation	IDA IDA: Inferred from direct assay	36691768	GOA
involved in ribosome hibernation	IDA IDA: Inferred from direct assay	36691768	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16879614	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16879614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERBP1 Protein Structure

HABP4_PAI-RBP1

0
100
200
300
408 a.a.

Protein Preferred Names

Protein Names

plasminogen activator inhibitor 1 RNA-binding protein

PAI-1 mRNA binding protein

SERBP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SERBP1	Q8NC51	TGFBR2	Homo sapiens	P37173	Validated Y2H	32814053
Intra	SERBP1	Q8NC51	TGFBR2	Homo sapiens	P37173	Y2H Pooling	32814053
Intra	SERBP1	Q8NC51	TGFBR2	Homo sapiens	P37173	Y2H Array	32814053
Intra	SERBP1	Q8NC51	SERPINH1	Homo sapiens	P50454	Validated Y2H	32814053
Intra	SERBP1	Q8NC51	SERPINH1	Homo sapiens	P50454	Y2H Array	32814053
Intra	SERBP1	Q8NC51	SERPINH1	Homo sapiens	P50454	Y2H Pooling	32814053
Intra	SERBP1	Q8NC51	CHD3	Homo sapiens	Q12873	Y2H	12505151
Intra	SERBP1	Q8NC51	CHD3	Homo sapiens	Q12873	Anti Bait CoIP	12505151
Intra	SERBP1	Q8NC51	CHD3	Homo sapiens	Q12873	Pull Down	12505151
Intra	SERBP1	Q8NC51	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	SERBP1	Q8NC51	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	SERBP1	Q8NC51	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	SERBP1	Q8NC51	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	SERBP1	Q8NC51	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	SERBP1	Q8NC51	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12687	SERBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SERBP1	VGNC	VGNC:46018
Felis catus	SERBP1	VGNC	VGNC:65016
Bos taurus	SERBP1	VGNC	VGNC:34461
Mus musculus	SERBP1	MGD	MGI:1914120
Macaca mulatta	SERBP1	VGNC	VGNC:81566
Rattus norvegicus	SERBP1	RGD	RGD:619907

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