AGO1 - argonaute RISC component 1 Gene

Homo sapiens

Also known as Q99; EIF2C; hAgo1; EIF2C1; GERP95

Gene ID: 26523 | Gene type: protein coding

About AGO1

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,869,761-35,930,532 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 4.5), brain (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to MicroRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

AGO1 Products(3)

mRNA	Protein	Name
NM_001317122.2	NP_001304051.1	protein argonaute-1 isoform 1x
NM_001317123.2	NP_001304052.1	protein argonaute-1 isoform 2
NM_012199.5	NP_036331.1	protein argonaute-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	23809764	GOA
NOT enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	23809764	GOA
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	25336585	GOA
enables core promoter sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	25336585	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	15260970	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12526743	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in RISC complex assembly	IDA IDA: Inferred from direct assay	19966796	GOA
involved in RNA secondary structure unwinding	IDA IDA: Inferred from direct assay	19966796	GOA
involved in RNA secondary structure unwinding	IMP IMP: Inferred from mutant phenotype	22795694	GOA
involved in miRNA processing	IMP IMP: Inferred from mutant phenotype	22795694	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	18771919	GOA
NOT involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23426184	GOA
involved in nuclear-transcribed mRNA catabolic process	IDA IDA: Inferred from direct assay	18771919	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25336585	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	19966796	GOA
NOT involved in siRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RISC complex	IDA IDA: Inferred from direct assay	15260970	GOA
part of RISC-loading complex	IDA IDA: Inferred from direct assay	19966796	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15260970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGO1 Protein Structure

ArgoL1

PAZ

Piwi

0
200
400
600
800
857 a.a.

Protein Preferred Names

Protein Names

protein argonaute-1

Golgi Endoplasmic Reticulum protein 95 kDa

Recombinant AGO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74424	AGO1 Protein, Human (sf9, His)	Q9UL18 (M1-A857)	≥95%

Related Diseases

Diseases

Alias

Tremor

Medicament-Induced Tremor

Medication-Induced Postural Tremor

Cartilage-Hair Hypoplasia

Metaphyseal Chondrodysplasia, Mckusick Type	CHH
Mckusick Type Metaphyseal Chondrodysplasia	Metaphyseal Dysplasia Without Hypotrichosis
Cartilage Hair Hypoplasia Like Syndrome	Metaphyseal Chondrodysplasia Mckusick Type
Chhv	Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only
Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency	Cartilage-Hair Syndrome
Mckusick'S Metaphyseal Chondrodysplasia Syndrome	Metaphyseal Chondrodysplasia, Recessive Type
Autosomal Recessive Metaphyseal Chondrodysplasia

Cervical Non-Keratinizing Squamous Cell Carcinoma

Retinitis Pigmentosa 7

Leber Congenital Amaurosis 18	RP7
Retinitis Pigmentosa 7, Digenic Form	Retinitis Pigmentosa 7 And Digenic Form
Retinitis Pigmentosa 7, Digenic	LCA18
Retinitis Pigmentosa 7 Digenic

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00452	AGO1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AGO1	RGD	RGD:1304619
Felis catus	AGO1	VGNC	VGNC:107483
Bos taurus	AGO1	VGNC	VGNC:25732
Macaca mulatta	AGO1	VGNC	VGNC:81346
Mus musculus	AGO1	MGD	MGI:2446630
Canis familiaris	AGO1	VGNC	VGNC:54192
Others	AGO1	NCBI

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