TNRC6C - trinucleotide repeat containing adaptor 6C Gene

Homo sapiens

Gene ID: 57690 | Gene type: protein coding

About TNRC6C

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:77,957,557-78,108,835 (from NCBI)

This gene has 11 transcripts (splice variants), 198 orthologues and 5 paralogues. Ubiquitous expression in brain (RPKM 4.2), testis (RPKM 3.1) and 25 other tissues.

Summary

Predicted to enable RNA binding activity. Involved in gene silencing by miRNA; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TNRC6C Products(7)

mRNA	Protein	Name
NM_001142640.2	NP_001136112.2	trinucleotide repeat-containing gene 6C protein isoform 1
NM_001395508.1	NP_001382437.1	trinucleotide repeat-containing gene 6C protein isoform 3
NM_001395509.1	NP_001382438.1	trinucleotide repeat-containing gene 6C protein isoform 4
NM_001395510.1	NP_001382439.1	trinucleotide repeat-containing gene 6C protein isoform 5
NM_001395511.1	NP_001382440.1	trinucleotide repeat-containing gene 6C protein isoform 6
NM_001395512.1	NP_001382441.1	trinucleotide repeat-containing gene 6C protein isoform 7
NM_018996.3	NP_061869.2	trinucleotide repeat-containing gene 6C protein isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19383768	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in miRNA-mediated post-transcriptional gene silencing	IGI IGI: Inferred from genetic interaction	23172285	GOA
involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	IDA IDA: Inferred from direct assay	21984185	GOA
involved in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	IDA IDA: Inferred from direct assay	21984185	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNRC6C Protein Structure

Ago_hook

UBA

M_domain

RRM_5

0
300
600
900
1200
1500
1690 a.a.

Protein Preferred Names

Protein Names

trinucleotide repeat-containing gene 6C protein

trinucleotide repeat containing 6C

TNRC6C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TNRC6C	Q9HCJ0	CNOT6L	Homo sapiens	Q96LI5	Pull Down	21984185
Intra	TNRC6C	Q9HCJ0	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	CNOT10	Homo sapiens	Q9H9A5	Pull Down	21984185
Intra	TNRC6C	Q9HCJ0	CNOT10	Homo sapiens	Q9H9A5	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	CNOT1	Homo sapiens	A5YKK6	Pull Down	21984185
Intra	TNRC6C	Q9HCJ0	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	CNOT7	Homo sapiens	Q9UIV1	Pull Down	21984185
Intra	TNRC6C	Q9HCJ0	AGO4	Homo sapiens	Q9HCK5	Confocal	19383768
Intra	TNRC6C	Q9HCJ0	PAN3	Homo sapiens	Q58A45	Anti Tag CoIP	21981923
Cross	TNRC6C	Q9HCJ0	Ago2	Mus musculus	Q8CJG0	Anti Tag CoIP	23340509
Intra	TNRC6C	Q9HCJ0	CNOT2	Homo sapiens	Q9NZN8	Pull Down	21984185
Intra	TNRC6C	Q9HCJ0	CNOT2	Homo sapiens	Q9NZN8	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	CNOT3	Homo sapiens	O75175	Pull Down	21984185
Intra	TNRC6C	Q9HCJ0	CNOT3	Homo sapiens	O75175	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	X-Ray Diffraction	20098421
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	ITC	20181956
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	23340509
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	GMS	20098421
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	21981923
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	NMR	20181956
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Pull Down	19716330
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Pull Down	20098421
Intra	TNRC6C	Q9HCJ0	PABPC1	Homo sapiens	P11940	Anti Tag CoIP	19716330

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14866	TNRC6C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TNRC6C	VGNC	VGNC:47700
Rattus norvegicus	TNRC6C	RGD	RGD:1310027
Macaca mulatta	TNRC6C	VGNC	VGNC:79800
Mus musculus	TNRC6C	MGD	MGI:2443265
Bos taurus	TNRC6C	VGNC	VGNC:36206
Felis catus	TNRC6C	VGNC	VGNC:99564

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