IL36RN - interleukin 36 receptor antagonist Gene

Homo sapiens

Also known as FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)

Gene ID: 26525 | Gene type: protein coding

About IL36RN

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,058,638-113,064,744 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues, 7 paralogues and is associated with 5 phenotypes. Biased expression in skin (RPKM 14.6), esophagus (RPKM 6.5) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight Other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

IL36RN Products(2)

mRNA	Protein	Name
NM_012275.3	NP_036407.1	interleukin-36 receptor antagonist protein
NM_173170.1	NP_775262.1	interleukin-36 receptor antagonist protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antifungal humoral response	IMP IMP: Inferred from mutant phenotype	23147407	GOA
involved in negative regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23147407	GOA
involved in negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	23147407	GOA
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	23147407	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL36RN Protein Structure

IL1

0
100
155 a.a.

Protein Preferred Names

Protein Names

interleukin-36 receptor antagonist protein

IL-1 related protein 3

IL36RN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IL36RN	Q9UBH0	UBL4B	Homo sapiens	Q8N7F7	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	UBL4B	Homo sapiens	Q8N7F7	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	CNOT4	Homo sapiens	O95628-2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	CNOT4	Homo sapiens	O95628-2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	HPCA	Homo sapiens	P84074	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	HPCA	Homo sapiens	P84074	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SH2B2	Homo sapiens	O14492-2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SH2B2	Homo sapiens	O14492-2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	AP3M1	Homo sapiens	Q9Y2T2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	AP3M1	Homo sapiens	Q9Y2T2	Validated Y2H	32296183
Intra	IL36RN	Q9UBH0	AP3M1	Homo sapiens	Q9Y2T2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	ZKSCAN4	Homo sapiens	Q969J2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	ZKSCAN4	Homo sapiens	Q969J2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Validated Y2H	25416956
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	25416956
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Prey Pooling	25416956
Intra	IL36RN	Q9UBH0	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	IL36RN	Q9UBH0	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	SSBP4	Homo sapiens	Q9BWG4	Y2H Pooling	16189514
Intra	IL36RN	Q9UBH0	SSBP4	Homo sapiens	Q9BWG4	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SSBP4	Homo sapiens	Q9BWG4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL36RN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71965	IL-36RN Protein, Human	Q9UBH0 (V2-D155)	≥95%
HY-P700127AF	Animal-Free IL-36RN Protein, Human (His)	Q9UBH0 (M1-T108)	≥95%

Related Diseases

Diseases

Alias

Psoriasis 14, Pustular

Generalized Pustular Psoriasis	Gpp
Ditra	Acrodermatitis Continua Of Hallopeau
Palmoplantar Pustulosis	PSORS14
Interleukin 36 Receptor Antagonist Deficiency	Psorp
Pustular Psoriasis 14	Deficiency Of Il-36r Antagonist
Acute Generalised Pustular Psoriasis	Deficiency Of The Interleukin-36 Receptor Antagonist
Generalized Pustular Psoriasis Of Von Zumbusch	Von Zumbusch Psoriasis
Deficiency Of Il-36ra	Psoriasis, Pustular, Generalized
Psoriasis, Pustular, Type 14	Pustulosis Of Palms And Soles
Acute Generalized Pustular Psoriasis	Palmoplantar Pustular Psoriasis
Pustulosis Palmaris Et Plantaris	Ppp - [Palmoplantar Pustulosis]
Pustular Psoriasis Of The Palms And Soles	Pustular Bacterid

Autoinflammatory Syndrome

Periodontitis, Aggressive, 1

Pustulosis Palmaris Et Plantaris	Ppp
Periodontitis, Juvenile	Localized Pustular Psoriasis
Jpd	Periodontitis 1, Juvenile
Lpp	Palmoplantar Pustulosis
Prepubertal Periodontitis	Periodontitis, Aggressive 1
Periodontitis, Prepubertal	Periodontititis, Aggressive, 1
AP1	Juvenile Periodontitis
Periodontitis Juvenile	Pustulosis Of Palms And Soles
Generalized Pustular Psoriasis

Acrodermatitis

Acute Generalized Exanthematous Pustulosis

Agep	Pustular Drug Eruption
Toxic Pustuloderma

Impetigo

Geographic Tongue

Benign Migratory Glossitis	Glossitis Areata Exfoliativa
Glossitis, Benign Migratory	Pityriasis Linguae
Ectopic Geographic Tongue	Erythema Migrans
Erythema Chronicum Migrans	Benign Migrating Glossitis
Geographical Tongue	Lingua Geographica
Erythema Migrans Of Tongue	Wandering Rash Of Tongue

Atrophic Glossitis

Atrophy Of Tongue Papillae	Glossitis, Hunter'S
Hunter'S Glossitis	Smooth Atrophic Tongue
Hunter Glossitis	Central Papillary Atrophy Of The Tongue

Impetigo Herpetiformis

Pustulosis Of Palm And Sole

Psoriasis	Acropustulosis
Palmoplantar Pustulosis	Pustular Psoriasis Of The Palms And/Or Soles
Pustulosis Of Palms And Soles	Acrodermatitis Continua Of Hallopeau
Generalized Pustular Psoriasis

Psoriasis

Pityriasis Rubra Pilaris

PRP	Devergie'S Disease
Prp - [Pityriasis Rubra Pilaris]

Erythema Elevatum Diutinum

Alopecia Areata

Aa	Alopecia Celsi
Alopecia Circumscripta	Cazenave'S Vitiligo
Celsus' Vitiligo	Diffuse Alopecia
Jonston'S Alopecia	Marginal Alopecia
Pseudopelade	Circumscribed Alopecia
Alopecia Cicatrisata	Patchy Alopecia
Alopecia	Aa - [Alopecia Areata]
Pelade

Psoriasis 13

PSORS13	Psoriasis 13, Susceptibility To
Psoriasis	Psoriasis Vulgaris
Psoriasis Susceptibility 13	Pv
Psoriasis, Susceptibility To, Type 13

Pulmonary Hemosiderosis

Idiopathic Pulmonary Hemosiderosis	Alveolar Hypoventilation Syndrome
Brown Induration	Brown Lung
Siderosis	Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin
Byssinosis

Psoriasis 15

Psors15

Periostitis

Psoriasis 3

PSORS3	Psoriasis Susceptibility 3
Psoriasis 3, Susceptibility To

Glossitis

Inflammation Of Tongue	Tongue Inflammation
Glazed Tongue

Periodic Fever, Familial, Autosomal Dominant

Familial Hibernian Fever	Tumor Necrosis Factor Receptor-Associated Periodic Syndrome
Traps	FPF
Tnf Receptor-Associated Periodic Fever Syndrome	Hibernian Fever, Familial
Fhf	Tnf Receptor-Associated Periodic Syndrome
Autosomal Dominant Familial Periodic Fever	Periodic Fever, Familial
Tnf Receptor 1-Associated Periodic Syndrome	Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome
Familial Periodic Fever	Traps Syndrome
Tnf Receptor Associated Periodic Syndrome	Caledonian Fever
Fever, Periodic, Familial	Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome

Autoimmune Disease Of Skin And Connective Tissue

Neutrophilic Dermatosis, Acute Febrile

Sweet Syndrome	Acute Febrile Neutrophilic Dermatosis
Ss	AFND
Pyrin-Associated Autoinflammatory Disease	PAAND
Gomm-Button Disease	Sweet'S Syndrome
Gomm Button Disease	Sweets Syndrome
Acromelic Frontonasal Dysostosis	Sweet Disease

Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne

Papa Syndrome	Fra
Familial Recurrent Arthritis	Pyogenic Arthritis, Pyoderma Gangrenosum And Acne
PAPAS	Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome
Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne	Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne

Pyoderma

Cinca Syndrome

CINCA	Nomid
Cryopyrin-Associated Periodic Syndrome 3	Chronic Neurologic Cutaneous And Articular Syndrome
Multisystem Inflammatory Disease, Neonatal-Onset	Caps3
Chronic Infantile Neurological Cutaneous Articular Syndrome	Infantile-Onset Multisystem Inflammatory Disease
Iomid Syndrome	Neonatal-Onset Multisystem Inflammatory Disease
Nomid Syndrome	Prieur-Griscelli Syndrome
Neonatal Onset Multisystem Inflammatory Disease	Chronic Infantile Neurological, Cutaneous And Articular Syndrome
Iomid	Infantile Onset Multisystem Inflammatory Disease
Prieur Griscelli Syndrome	Chronic Infantile Neurological Cutaneous And Articular Syndrome
Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome	Chronic Infantile Neurologic Cutaneous And Articular Syndrome
Chronic Infantile Neurological, Cutaneous, And Articular Syndrome	Cryopyrin-Associated Periodic Syndromes

Psoriasis 11

PSORS11	Psoriasis Susceptibility 11
Psoriasis	Psoriasis Vulgaris
Psoriasis 11, Susceptibility To	Pv

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06762	IL36RN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IL36RN	VGNC	VGNC:41985
Mus musculus	IL36RN	MGD	MGI:1859325
Rattus norvegicus	IL36RN	RGD	RGD:1311212
Macaca mulatta	IL36RN	VGNC	VGNC:106173
Bos taurus	IL36RN	VGNC	VGNC:30159
Others	IL36RN	NCBI