RGS17 - regulator of G protein signaling 17 Gene

Homo sapiens

Also known as RGSZ2; RGS-17; hRGS17

Gene ID: 26575 | Gene type: protein coding

About RGS17

Cytogenetic location: 6q25.2 Genomic coordinates (GRCh38): 6:153,004,459-153,131,282 (from NCBI)

This gene has 2 transcripts (splice variants), 207 orthologues and 23 paralogues. Broad expression in thyroid (RPKM 1.8), brain (RPKM 1.6) and 17 other tissues.

Summary

This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]

RGS17 Products(1)

mRNA	Protein	Name
NM_012419.5	NP_036551.3	regulator of G-protein signaling 17

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS17 Protein Structure

RGS

0
100
210 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 17

RGS17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGS17	Q9UGC6	PTGER3	Homo sapiens	P43115-12	Y2H Array	25416956
Intra	RGS17	Q9UGC6	LCE3C	Homo sapiens	Q5T5A8	Y2H Prey Pooling	25416956
Intra	RGS17	Q9UGC6	LCE4A	Homo sapiens	Q5TA78	Y2H Array	25416956
Intra	RGS17	Q9UGC6	LCE4A	Homo sapiens	Q5TA78	Y2H Prey Pooling	25416956
Intra	RGS17	Q9UGC6	LCE2A	Homo sapiens	Q5TA79	Y2H Prey Pooling	25416956
Intra	RGS17	Q9UGC6	q9nwl9_human	Homo sapiens	Q9NWL9	Validated Y2H	25416956
Intra	RGS17	Q9UGC6	NUFIP2	Homo sapiens	Q7Z417	Validated Y2H	25416956
Intra	RGS17	Q9UGC6	NUFIP2	Homo sapiens	Q7Z417	Y2H Array	25416956
Intra	RGS17	Q9UGC6	GLE1	Homo sapiens	Q53GS7	Y2H Pooling	32814053
Intra	RGS17	Q9UGC6	GLE1	Homo sapiens	Q53GS7	Validated Y2H	32814053
Intra	RGS17	Q9UGC6	GLE1	Homo sapiens	Q53GS7	Y2H Array	32814053
Intra	RGS17	Q9UGC6	RPL10A	Homo sapiens	P62906	Y2H Array	25416956
Intra	RGS17	Q9UGC6	STUB1	Homo sapiens	Q9UNE7	Validated Y2H	32296183
Intra	RGS17	Q9UGC6	GNAI3	Homo sapiens	P08754	Y2H Array	25416956
Intra	RGS17	Q9UGC6	GNAI3	Homo sapiens	P08754	Y2H Prey Pooling	25416956
Intra	RGS17	Q9UGC6	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	RGS17	Q9UGC6	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	RGS17	Q9UGC6	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	RGS17	Q9UGC6	GNAI1	Homo sapiens	P63096	Y2H Array	25416956
Intra	RGS17	Q9UGC6	GNAI1	Homo sapiens	P63096	Validated Y2H	25416956
Intra	RGS17	Q9UGC6	CRCT1	Homo sapiens	Q9UGL9	Validated Y2H	32296183
Intra	RGS17	Q9UGC6	OTX1	Homo sapiens	P32242	Y2H Array	25416956
Intra	RGS17	Q9UGC6	OTX1	Homo sapiens	P32242	Validated Y2H	25416956
Intra	RGS17	Q9UGC6	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	25416956
Intra	RGS17	Q9UGC6	HOXA1	Homo sapiens	P49639	Y2H Array	25416956
Intra	RGS17	Q9UGC6	AQP1	Homo sapiens	P29972	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RGS17 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700384	RGS17 Protein, Human (GST)	Q9UGC6 (M1-S210)	≥95%

Related Diseases

Diseases

Alias

Jejunal Somatostatinoma

Jejunal Delta Cell Somatostatin Producing Tumor	Somatosatinoma Of Jejunum
Jejunal Somatostatin-Producing Neuroendocrine Tumor

Posterior Uveal Melanoma

Medium/Large Size Posterior Uveal Melanoma	Small Size Posterior Uveal Melanoma
Ciliary Body And Choroid Melanoma, Medium/Large Size	Ciliary Body And Choroid Melanoma, Small Size

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11911	RGS17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RGS17	VGNC	VGNC:45526
Macaca mulatta	RGS17	VGNC	VGNC:76731
Bos taurus	RGS17	VGNC	VGNC:33916
Felis catus	RGS17	VGNC	VGNC:102501
Rattus norvegicus	RGS17	RGD	RGD:1305515
Mus musculus	RGS17	MGD	MGI:1927469
Others	RGS17	NCBI

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