2. Gene
  3. ARHGEF16 - Rho guanine nucleotide exchange factor 16 Gene

ARHGEF16 - Rho guanine nucleotide exchange factor 16 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NBR; GEF16

Gene ID: 27237 | Gene type: protein coding

About ARHGEF16

Cytogenetic location: 1p36.32 Genomic coordinates (GRCh38): 1:3,454,665-3,481,113 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 6 paralogues. Broad expression in duodenum (RPKM 15.0), small intestine (RPKM 12.9) and 17 other tissues.

Summary

Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

ARHGEF16 Products(1)

mRNA Protein Name
NM_014448.4 NP_055263.2 rho guanine nucleotide exchange factor 16
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
21139582 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
20679435 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15161933 GOA
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
20679435 GOA
enables small GTPase binding IPI
IPI: Inferred from physical interaction
20679435 GOA
Biological Process GO Annotation Evidence Reference Source
involved in activation of GTPase activity IDA
IDA: Inferred from direct assay
21139582 GOA
involved in activation of GTPase activity IMP
IMP: Inferred from mutant phenotype
20679435 GOA
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
20679435 GOA
involved in positive regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
20679435 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF16 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (289 - 467)

PH

PH: PH domain (502 - 617)

SH3_9

SH3_9: Variant SH3 domain (640 - 683)

  • 0
  • 200
  • 400
  • 600
  • 709 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 16

Rho guanine exchange factor (GEF) 16

ARHGEF16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ARHGEF16 Q5VV41 BOLL Homo sapiens Q8N9W6-4
Y2H Prey Pooling
32296183
Intra
ARHGEF16 Q5VV41 BOLL Homo sapiens Q8N9W6-4
Validated Y2H
32296183
Intra
ARHGEF16 Q5VV41 BOLL Homo sapiens Q8N9W6-4
Y2H Array
32296183
Intra
ARHGEF16 Q5VV41 YWHAZ Homo sapiens P63104
Anti Tag CoIP
33961781
Intra
ARHGEF16 Q5VV41 YWHAZ Homo sapiens P63104
Pull Down
15161933
Intra
ARHGEF16 Q5VV41 HNRNPH1 Homo sapiens P31943
Y2H Array
32296183
Intra
ARHGEF16 Q5VV41 HNRNPH1 Homo sapiens P31943
Y2H Prey Pooling
32296183
Intra
ARHGEF16 Q5VV41 YWHAE Homo sapiens P62258
Crosslink
36931259
Intra
ARHGEF16 Q5VV41 TFG Homo sapiens Q92734
Y2H Array
25416956
Intra
ARHGEF16 Q5VV41 TFG Homo sapiens Q92734
Validated Y2H
25416956
Intra
ARHGEF16 Q5VV41 SCRIB Homo sapiens Q14160
Anti Tag CoIP
32203420
Intra
ARHGEF16 Q5VV41 DLG1 Homo sapiens Q12959
Anti Tag CoIP
32203420
Intra
ARHGEF16 Q5VV41 MAGED1 Homo sapiens Q9Y5V3
Y2H Prey Pooling
32296183
Intra
ARHGEF16 Q5VV41 MAGED1 Homo sapiens Q9Y5V3
Validated Y2H
32296183
Intra
ARHGEF16 Q5VV41 MAGED1 Homo sapiens Q9Y5V3
Y2H Array
32296183
Intra
ARHGEF16 Q5VV41 MAPK1IP1L Homo sapiens Q8NDC0
Validated Y2H
25416956
Intra
ARHGEF16 Q5VV41 LASP1 Homo sapiens Q14847-2
Y2H Prey Pooling
32296183
Intra
ARHGEF16 Q5VV41 LASP1 Homo sapiens Q14847-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized 2

EIG2

Epilepsy, Idiopathic Generalized, Susceptibility To, 2

Idiopathic Generalized Epilepsy 2

Epilepsy, Idiopathic Generalized Locus On Chromosome 14

Epilepsy, Idiopathic Generalized, Susceptibility To, Locus On Chromosome 14
Frontal Sinusitis
Facial Neuralgia
Gastrojejunal Ulcer

Acute Gastrojejunal Ulcer With Hemorrhage

Acute Gastrojejunal Ulcer With Hemorrhage And Obstruction

Acute Gastrojejunal Ulcer With Hemorrhage And Perforation

Acute Gastrojejunal Ulcer With Hemorrhage And Perforation, With Obstruction

Acute Gastrojejunal Ulcer With Hemorrhage, With Perforation And With Obstruction

Acute Gastrojejunal Ulcer With Perforation

Acute Gastrojejunal Ulcer With Perforation And Obstruction

Acute Gastrojejunal Ulcer With Perforation, With Obstruction

Acute Gastrojejunal Ulcer Without Hemorrhage And Without Perforation

Acute Gastrojejunal Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

Acute Gastrojejunal Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

Acute Gastrojejunal Ulcer, With Hemorrhage, With Obstruction

Chronic Gastrojejunal Ulcer Without Hemorrhage And Without Perforation

Chronic Gastrojejunal Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

Chronic Gastrojejunal Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

Marginal Ulcer
Locked-In Syndrome

Locked In Syndrome

Cerebromedullospinal Disconnection

Locked-In State

Quadriplegia
Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I

OI1

Oi, Type I

Osteogenesis Imperfecta Tarda

Osteogenesis Imperfecta With Blue Sclerae

Osteogenesis Imperfecta Type 1

Adair-Dighton Syndrome

Mild Osteogenesis Imperfecta

Non-Deforming Osteogenesis Imperfecta

Oi Type 1

Van Der Hoeve Syndrome

Classic Non-Deforming Oi With Blue Sclerae

Osteogenesis Imperfecta 1

Oi-I

Osteopenic Non-Fracture Syndrome

Osteogenesis Imperfecta, Mild

Osteogenesis Imperfecta

Lobstein'S Disease
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00951 ARHGEF16 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ARHGEF16 RGD RGD:1588981
Mus musculus ARHGEF16 MGD MGI:2446219
Bos taurus ARHGEF16 VGNC VGNC:26108
Felis catus ARHGEF16 VGNC VGNC:59901
Canis familiaris ARHGEF16 VGNC VGNC:38077
Macaca mulatta ARHGEF16 VGNC VGNC:69830