GLP1R - glucagon like peptide 1 receptor Gene

Homo sapiens

Also known as GLP-1; GLP-1R; GLP-1-R

Gene ID: 2740 | Gene type: protein coding

About GLP1R

Cytogenetic location: 6p21.2 Genomic coordinates (GRCh38): 6:39,048,781-39,091,303 (from NCBI)

This gene has 1 transcript (splice variant), 127 orthologues and 42 paralogues. Biased expression in heart (RPKM 1.0), brain (RPKM 1.0) and 10 other tissues.

Summary

This gene encodes a 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced Insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to Insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

GLP1R Products(1)

mRNA	Protein	Name
NM_002062.5	NP_002053.3	glucagon-like peptide 1 receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables glucagon-like peptide 1 receptor activity	IDA IDA: Inferred from direct assay	28514449	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	28514449	GOA
involved in cAMP-mediated signaling	IDA IDA: Inferred from direct assay	7589461	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	7589461	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	28514449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLP1R Protein Structure

HRM

7tm_2

0
100
200
300
400
463 a.a.

Protein Preferred Names

Protein Names

glucagon-like peptide 1 receptor

GLP-1 receptor

Recombinant GLP1R Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70352	GLP1R Protein, Human (HEK293, Fc)	P43220 (R24-Y145)	≥95%
HY-P700468	GLP1R Protein, Human (HEK293, N-His, C-Myc)	P43220 (R24-Y145)	≥95%

Related Diseases

Diseases

Alias

Insulinoma

Islet Cell Adenoma	Insulin-Producing Tumor Of Islet Cells
Adenoma Islet Cell	Islet Cell Tumor
Experimental Organism Islet Cell Adenoma Neoplasm

Hyperglycemia

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis	KPD
Diabetes Mellitus, Ketosis-Prone, Susceptibility To	Ketosis-Prone Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent	Diabetic Ketoacidosis Nos
Dka - [Diabetic Ketoacidosis] Nos	Dka - [Diabetic Ketoacidosis] Without Coma
Dka - [Diabetic Ketoacidosis] With Coma

Diabetes Mellitus

Diabetes

Hyperinsulinism

Hyperinsulinemia

Prediabetes Syndrome

Prediabetes	Impaired Glucose Tolerance
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Hyperinsulinemic Hypoglycemia

Nesidioblastosis	Islet Cell Hyperplasia
Persistent Hyperinsulinemia Hypoglycemia Of Infancy	Hyperinsulinemic Hypoglycaemia

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Gall Duct
Ca Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Biliary Passages
Intrahepatic Bile Duct Carcinoma

Dipsogenic Diabetes Insipidus

Primary Polydipsia	Doid:0081058
Psychogenic Polydipsia

Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism	Disorder Of Carbohydrate Metabolism
Carbohydrate Metabolism, Inborn Errors	Disorder Of Carbohydrate Transport And Metabolism
Inborn Carbohydrate Metabolism Disorder	Inborn Carbohydrate Metabolic Disorder
Carbohydrate Metabolism Disorder	Carbohydrate Metabolism Disorders
Disorders Of Carbohydrate Metabolism	Congenital Disorders Of Carbohydrate Metabolism
Inherited Disorders Of Carbohydrate Metabolism

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Inherited Metabolic Disorder

Inborn Errors Of Metabolism	Inborn Metabolic Disorder
Inborn Metabolism Disorder	Metabolic Hereditary Disorder
Inborn Error Of Metabolism	Metabolism, Inborn Errors

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P3506	Retatrutide	Agonist	99.95%	Phase 3
HY-112185	Orforglipron	Agonist	99.80%	Phase 3
HY-P3375	Mazdutide	Agonist	99.74%	Phase 3
HY-P3506A	Retatrutide TFA	Agonist	99.31%	Phase 3
HY-P3375A	Mazdutide TFA	Agonist	/	Phase 3
HY-P3506B	Retatrutide acetate	Agonist	/	Phase 3
HY-125824	Danuglipron	Agonist	98.63%	Phase 2
HY-P4146	Survodutide	Agonist	99.83%	Phase 2
HY-P3291	Dapiglutide	Agonist	99.40%	Phase 2
HY-P4146A	Survodutide TFA	Agonist	99.62%	Phase 2
HY-P10019	Pegsebrenatide	Agonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (57)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121835	GLP-1R agonist 2	Agonist	99.94%	Unkown
HY-101116	GLP-1R Antagonist 1	Antagonist	99.84%	Unkown
HY-153865	Lotiglipron	Agonist	99.68%	Unkown
HY-142162	LSN3318839	Modulator	99.81%	Unkown
HY-143312	V-0219	Modulator	98.65%	Unkown
HY-112679	GLP-1 receptor agonist 2	Agonist	98.70%	Unkown
HY-141839	GLP-1R modulator C16	Modulator	99.60%	Unkown
HY-116819A	VU0453379 hydrochloride	Modulator	≥99.0%	Unkown
HY-141842	GLP-1R modulator L7-028	Modulator	98.77%	Unkown
HY-143312A	V-0219 hydrochloride	Modulator	99.65%	Unkown
HY-141840	GLP-1R modulator C5	Modulator	99.60%	Unkown
HY-144035	GLP-1R agonist 4	Agonist	98.26%	Unkown
HY-144034	GLP-1R agonist 3	Agonist	99.15%	Unkown
HY-147625	GLP-1R agonist 12	Agonist	95.06%	Unkown
HY-148212	GLP-1R agonist 17	Agonist	/	Unkown
HY-P10302A	GLP-1R/GIPR agonist-1 (soduim)	Agonist	96.55%	Unkown
HY-112185A	Orforglipron hemicalcium hydrate	Agonist	99.48%	Unkown
HY-116819	VU0453379	Modulator	≥98.0%	Unkown
HY-143312E	(S)-V-0219 hydrochloride	Modulator	99.71%	Unkown
HY-147623	GLP-1R agonist 10	Agonist	98.99%	Unkown
HY-143312D	(R)-V-0219 hydrochloride	Modulator	99.37%	Unkown
HY-147622	GLP-1R agonist 9	Agonist	/	Unkown
HY-P10302	GLP-1R/GIPR agonist-1	Agonist	/	Unkown
HY-P10716	Exendin-P5	Activator	/	Unkown
HY-138996	GLP-1 receptor agonist 8	Agonist	/	Unkown
HY-120828	Albenatide	Agonist	/	Unkown
HY-129657	GLP-1 receptor agonist 4	Agonist	/	Unkown
HY-143312B	(R)-V-0219	Modulator	/	Unkown
HY-143312C	(S)-V-0219	Modulator	/	Unkown
HY-144033	GLP-1R agonist 1	Agonist	/	Unkown
HY-144133	GLP-1R agonist 5	Agonist	/	Unkown
HY-144134	GLP-1R agonist 6	Agonist	/	Unkown
HY-144135	GLP-1R agonist 7	Agonist	/	Unkown
HY-144136	GLP-1R agonist 8	Agonist	/	Unkown
HY-147626	GLP-1R agonist 13	Agonist	/	Unkown
HY-147627	GLP-1R agonist 14	Agonist	/	Unkown
HY-147628	GLP-1R agonist 15	Agonist	/	Unkown
HY-147629	GLP-1R agonist 16	Agonist	/	Unkown
HY-153193	LSN3160440	Modulator	/	Unkown
HY-160031	GLP-1R agonist 19	Agonist	/	Unkown
HY-161915	GLP-1R agonist 23	Agonist	/	Unkown
HY-162306	GLP-1R agonist 18	Agonist	/	Unkown
HY-162435	GLP-1R agonist 20	Agonist	/	Unkown
HY-162436	GLP-1R agonist 21	Agonist	/	Unkown
HY-162437	GLP-1R agonist 22	Agonist	/	Unkown
HY-162979	GLP-1R agonist 25	Agonist	/	Unkown
HY-163996	DD202-114	Agonist	98.47%	Unkown
HY-P0264A	Exendin(9-39) amide acetate	Antagonist	/	Unkown
HY-P10337	OXM-7	Agonist	/	Unkown
HY-P3539	Exendin-4 (3-39)		/	Unkown
HY-P3542	Des His1, Glu8 Exendin-4	Antagonist	/	Unkown
HY-P4386	(Asp28)-Exenatide	Agonist	/	Unkown
HY-P5161A	FC382K10W15 TFA	Agonist	/	Unkown
HY-RS05490	GLP1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125824A	Danuglipron tromethamine	Agonist	/	Unkown
HY-142162A	(S,R)-LSN3318839		/	Unkown
HY-168585	GLP-1R agonist 26	Agonist	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990013	Gulgafafusp alfa	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GLP1R	VGNC	VGNC:29410
Mus musculus	GLP1R	MGD	MGI:99571
Macaca mulatta	GLP1R	VGNC	VGNC:73072
Canis familiaris	GLP1R	VGNC	VGNC:41266
Felis catus	GLP1R	VGNC	VGNC:62586
Rattus norvegicus	GLP1R	RGD	RGD:2703
Others	GLP1R	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.