GNAI2 - G protein subunit alpha i2 Gene

Homo sapiens

Also known as GIP; HG1C; GNAI2B; H_LUCA15.1; H_LUCA16.1

Gene ID: 2771 | Gene type: protein coding

About GNAI2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,227,068-50,263,358 (from NCBI)

This gene has 12 transcripts (splice variants), 292 orthologues, 15 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 106.7), bone marrow (RPKM 93.2) and 25 other tissues.

Summary

The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of Adenylate Cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

GNAI2 Products(6)

mRNA	Protein	Name
NM_001166425.2	NP_001159897.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 2
NM_001282617.2	NP_001269546.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 3
NM_001282618.2	NP_001269547.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 4
NM_001282619.2	NP_001269548.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 5
NM_001282620.2	NP_001269549.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 6
NM_002070.4	NP_002061.1	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell division	IMP IMP: Inferred from mutant phenotype	17635935	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21079996	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	17635935	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17635935	GOA
located in midbody	IDA IDA: Inferred from direct assay	17635935	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17635935	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNAI2 Protein Structure

G-alpha

0
100
200
300
355 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-2

GTP-binding regulatory protein Gi alpha-2 chain

Related Diseases

Diseases

Alias

Ventricular Tachycardia, Familial

Familial Ventricular Tachycardia	Ventricular Tachycardia, Familial Polymorphic
Ventricular Tachycardia, Idiopathic

Granulosa Cell Tumor Of The Ovary

Adult Granulosa Cell Tumor Of The Ovary	Gct Of The Ovary
Gtct	Granulosa Theca Cell Tumor
Granulosa Theca Cell Tumor Of The Ovary

Pituitary Adenoma 4, Acth-Secreting

PITA4	Cushing Disease, Pituitary
Pituitary Adenoma 4, Acth-Secreting, Somatic	Cushing Disease
Pituitary Cushing Disease	Adenoma, Pituitary, Acth-Secreting, Type 4
Pituitary-Dependent Cushing'S Disease

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Hyperinsulinemic Hypoglycemia, Familial, 5

Hyperinsulinism Due To Insr Deficiency	HHF5
Familial Hyperinsulinemic Hypoglycemia 5	Hyperinsulinemic Hypoglycemia Due To Insr Deficiency
Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency	Congenital Hyperinsulinism
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
Hyperinsulinemic Hypoglycemia Familial 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05535	GNAI2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GNAI2	VGNC	VGNC:62617
Rattus norvegicus	GNAI2	RGD	RGD:620243
Mus musculus	GNAI2	MGD	MGI:95772
Canis familiaris	GNAI2	VGNC	VGNC:41302
Bos taurus	GNAI2	VGNC	VGNC:29450
Macaca mulatta	GNAI2	VGNC	VGNC:73090

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