DBNL - drebrin like Gene

Homo sapiens

Also known as ABP1; HIP55; SH3P7; HIP-55

Gene ID: 28988 | Gene type: protein coding

About DBNL

Cytogenetic location: 7p13 Genomic coordinates (GRCh38): 7:44,044,702-44,069,456 (from NCBI)

This gene has 22 transcripts (splice variants), 268 orthologues and 4 paralogues. Ubiquitous expression in esophagus (RPKM 54.1), spleen (RPKM 52.7) and 25 other tissues.

Summary

Enables cadherin binding activity. Predicted to be involved in several processes, including Rac protein signal transduction; nervous system development; and podosome assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DBNL Products(6)

mRNA	Protein	Name
NM_001014436.3	NP_001014436.1	drebrin-like protein isoform b
NM_001122956.2	NP_001116428.1	drebrin-like protein isoform c
NM_001284313.2	NP_001271242.1	drebrin-like protein isoform d
NM_001284315.2	NP_001271244.1	drebrin-like protein isoform e
NM_001362723.2	NP_001349652.1	drebrin-like protein isoform f
NM_014063.7	NP_054782.2	drebrin-like protein isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBNL Protein Structure

Cofilin_ADF

SH3_9

0
100
200
300
400
430 a.a.

Protein Preferred Names

Protein Names

drebrin-like protein

HPK1-interacting protein of 55 kDa

Related Diseases

Diseases

Alias

Glycogen Storage Disease X

Myopathy Due To Phosphoglycerate Mutase Deficiency	GSD10
Pgamm Deficiency	Gsd X
Muscle Phosphoglycerate Mutase Deficiency	Glycogen Storage Disease Type X
Phosphoglycerate Mutase Deficiency	Gsdx
Pgam Deficiency	Phosphoglycerate Mutase, Muscle, Deficiency Of
Deficiency Mutase Phosphoglycerate	Glycogen Storage Disease Due To Phosphoglycerate Mutase Deficiency
Gsd Due To Phosphoglycerate Mutase Deficiency	Gsd Type 10
Glycogenosis Due To Phosphoglycerate Mutase Deficiency	Glycogen Storage Disease 10
Storage Disease, Glycogen, Type X

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03551	DBNL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DBNL	VGNC	VGNC:97186
Mus musculus	DBNL	MGD	MGI:700006
Felis catus	DBNL	VGNC	VGNC:61349
Macaca mulatta	DBNL	VGNC	VGNC:108394
Bos taurus	DBNL	VGNC	VGNC:27893
Rattus norvegicus	DBNL	RGD	RGD:70941
Others	DBNL	NCBI

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