Cd36 - CD36 molecule Gene

Rattus norvegicus

Also known as Fat; RGD1562323

Gene ID: 29184 | Gene type: protein coding

About Cd36

Summary

Enables several functions, including oleic acid binding activity; scavenger receptor activity; and thrombospondin receptor activity. Involved in several processes, including fatty acid metabolic process; positive regulation of macromolecule metabolic process; and response to peptide hormone. Located in several cellular components, including brush border membrane; caveola; and sarcolemma. Part of protein-containing complex. Used to study interstitial lung disease (multiple); macular degeneration; myocardial infarction; obesity; and polycystic ovary syndrome. Biomarker of artery disease (multiple); hypertrophic cardiomyopathy; nephrosis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd36 Products(1)

mRNA	Protein	Name
NM_031561.2	NP_113749.2	platelet glycoprotein 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables oleic acid binding	IDA IDA: Inferred from direct assay	8320718	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15161924	RGD
enables scavenger receptor activity	IMP IMP: Inferred from mutant phenotype	18941241	RGD
enables thrombospondin receptor activity	IDA IDA: Inferred from direct assay	10487979	RGD
enables transforming growth factor beta binding	IDA IDA: Inferred from direct assay	10487979	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta clearance by cellular catabolic process	IMP IMP: Inferred from mutant phenotype	18941241	RGD
involved in cell-cell adhesion via plasma-membrane adhesion molecules	IEP IEP: Inferred from expression pattern	24317495	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	19273501	RGD
involved in digestive tract development	IEP IEP: Inferred from expression pattern	11595646	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	25477422	RGD
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	23557700	RGD
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	11729182	RGD
involved in fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	11175782	RGD
involved in fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	15161924	RGD
involved in fatty acid transport	IDA IDA: Inferred from direct assay	14748718	RGD
involved in fatty acid transport	IEP IEP: Inferred from expression pattern	16684853	RGD
involved in fatty acid transport	IMP IMP: Inferred from mutant phenotype	15331529	RGD
involved in long-chain fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	15161924	RGD
involved in long-chain fatty acid transport	IMP IMP: Inferred from mutant phenotype	9315741	RGD
involved in maternal placenta development	IEP IEP: Inferred from expression pattern	24391823	RGD
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	18772338	RGD
involved in negative regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	22128087	RGD
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	20075072	RGD
involved in positive regulation of glycogen biosynthetic process	IDA IDA: Inferred from direct assay	14640889	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	23238794	RGD
involved in positive regulation of triglyceride metabolic process	IDA IDA: Inferred from direct assay	23099442	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	18941241	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	17374701	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17640331	RGD
involved in response to fatty acid	IDA IDA: Inferred from direct assay	21610069	RGD
involved in response to fatty acid	IMP IMP: Inferred from mutant phenotype	23557700	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	17640331	RGD
involved in response to lipid	IMP IMP: Inferred from mutant phenotype	21610069	RGD
involved in response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	18772338	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	17640331	RGD
involved in response to vitamin B3	IEP IEP: Inferred from expression pattern	19878707	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15492479	RGD
involved in triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	15331529	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	9315741	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	21610069	RGD
located in caveola	IDA IDA: Inferred from direct assay	12637562	RGD
located in cell surface	IDA IDA: Inferred from direct assay	10487979	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	20237389	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	12829625	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

platelet glycoprotein 4

CD36 antigen (collagen type I receptor, thrombospondin receptor)	CD36 molecule (thrombospondin receptor)
Cd36 antigen-like	GPIIIB
GPIV	PAS IV
PAS-4	adipocyte membrane protein
collagen type I receptor thrombospondin receptor	fatty acid translocase

Recombinant Cd36 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74302	CD36 Protein, Rat (HEK293, His)	Q07969 (G30-K439)	≥95%
HY-P74303	CD36 Protein, Rat (HEK293, Fc)	Q07969 (G30-K439)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112847A	Sulfosuccinimidyl oleate sodium	Inhibitor	≥98.0%	Unkown
HY-163541	SMS121	Inhibitor	98.75%	Unkown
HY-P3970A	KRFK TFA	Agonist	99.90%	Unkown
HY-126726	KOdiA-PC		≥99.0%	Unkown
HY-128671	6-Thioinosine		98.82%	Unkown
HY-116003	12,13-DiHOME		≥99.0%	Unkown
HY-112847	Sulfosuccinimidyl oleate	Inhibitor	/	Unkown
HY-154857	1-Palmitoyl-2-succinyl-sn-glycerophosphorylcholine		/	Unkown
HY-RS02237	CD36 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-125554	KDdiA-PC		/	Unkown
HY-163649	A17	Activator	/	Unkown
HY-168049	ZLY06	Agonist	/	Unkown
HY-P10388	TAX2 peptide		/	Unkown
HY-P3970	KRFK	Agonist	/	Unkown
HY-112847B	(E/Z)-Sulfosuccinimidyl oleate sodium		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd36	NCBI	NCBI:948
Canis familiaris	Cd36	NCBI	NCBI:475931
Macaca fascicularis	Cd36	NCBI	NCBI:101926577
Mus musculus	Cd36	NCBI	NCBI:12491
Macaca mulatta	Cd36	NCBI	NCBI:574296

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