Fto - FTO, alpha-ketoglutarate dependent dioxygenase Gene

Rattus norvegicus

Also known as RGD1305121

Gene ID: 291905 | Gene type: protein coding

About Fto

Primary_assembly 19: 15,349,696-15,692,083 reverse strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 202 orthologues and is associated with 14 phenotypes. Biased expression in Brain (RPKM 136.3), Kidney (RPKM 111.9) and 9 other tissues.

Summary

Predicted to enable 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Predicted to be involved in several processes, including mRNA destabilization; nucleic acid metabolic process; and regulation of respiratory system process. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FTO (FTO alpha-ketoglutarate dependent dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Fto Products(1)

mRNA	Protein	Name
NM_001039713.1	NP_001034802.1	alpha-ketoglutarate-dependent dioxygenase FTO

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in heart development	IEP IEP: Inferred from expression pattern	36426889	RGD
involved in negative regulation of eating behavior	IMP IMP: Inferred from mutant phenotype	20098739	RGD
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	35006515	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	30835997	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	29890211	RGD
involved in regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	30835997	RGD
involved in response to bisphenol A	IEP IEP: Inferred from expression pattern	35945320	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	28179100	RGD
involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	33829413	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fto Protein Structure

FTO_NTD

FTO_CTD

0
100
200
300
400
502 a.a.

Protein Preferred Names

Protein Names

alpha-ketoglutarate-dependent dioxygenase FTO

U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO	U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
fat mass and obesity associated	fat mass and obesity-associated protein
m6A(m)-demethylase FTO	mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
mRNA N(6)-methyladenosine demethylase FTO	protein fto
tRNA N1-methyl adenine demethylase FTO

Related Agents

Approval

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14280	Entacapone	Inhibitor	99.97%	Yes
HY-B1320	Meclofenamic acid sodium	Inhibitor	99.86%	Unkown
HY-117275	Meclofenamic acid	Inhibitor	98.60%	Unkown
HY-101082	N6,2′-O-Dimethyladenosine	Inhibitor	99.93%	Unkown
HY-117275A	Meclofenamic acid sodium hydrate	Inhibitor	/	Unkown
HY-14280R	Entacapone (Standard)	Inhibitor	/	Unkown
HY-14280A	Entacapone sodium salt	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-127103	FB23-2	Inducer	99.93%	Unkown
HY-137187	FB23		98.66%	Unkown
HY-N6769	Radicicol	Inhibitor	99.63%	Unkown
HY-151106	FTO-IN-8	Inhibitor	98.03%	Unkown
HY-145238	FTO-IN-6		98.94%	Unkown
HY-138843A	FTO-IN-1 TFA		98.04%	Unkown
HY-149334	ZLD115	Inhibitor	99.24%	Unkown
HY-147011	FTO-IN-7	Inhibitor	99.22%	Unkown
HY-132865	FTO-IN-3		99.79%	Unkown
HY-RS05137	Fto Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W588293	3-Methylthymidine		99.68%	Unkown
HY-14280S	Entacapone-d10	Inhibitor	≥98.0%	Unkown
HY-117275S	Meclofenamic acid-d4	Inhibitor	/	Unkown
HY-117275S1	Meclofenamic acid-13C6	Inhibitor	/	Unkown
HY-117426	MO-I-500	Inhibitor	99.10%	Unkown
HY-132863	FTO-IN-2		/	Unkown
HY-138843	FTO-IN-1		/	Unkown
HY-139820	FTO-IN-4		/	Unkown
HY-139821	FTO-IN-5		/	Unkown
HY-156405	FTO-IN-10		/	Unkown
HY-N10340	Clausine E	Inhibitor	/	Unkown
HY-RS05136	FTO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05138	Fto Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W026109	FTO-IN-12	Inhibitor	/	Unkown
HY-131871	Ethyl LipotF	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fto	NCBI	NCBI:79068

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