2. Gene
  3. SENP1 - SUMO specific peptidase 1 Gene

SENP1 - SUMO specific peptidase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SuPr-2

Gene ID: 29843 | Gene type: protein coding

About SENP1

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:48,042,897-48,106,079 (from NCBI)

This gene has 10 transcripts (splice variants), 204 orthologues and 3 paralogues. Broad expression in testis (RPKM 36.5), lymph node (RPKM 5.6) and 18 other tissues.

Summary

This gene encodes a cysteine Protease that specifically targets members of the small ubiquitin-like modifier (SUMO) protein family. This Protease regulates SUMO pathways by deconjugating sumoylated proteins. This Protease also functions to process the precursor SUMO proteins into their mature form. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

SENP1 Products(2)

mRNA Protein Name
NM_001267594.2 NP_001254523.1 sentrin-specific protease 1
NM_001267595.2 NP_001254524.1 sentrin-specific protease 1

SENP1 Protein Structure

Peptidase_C48

Peptidase_C48: Ulp1 protease family, C-terminal catalytic domain (464 - 634)

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  • 643 a.a.
Protein Preferred Names Protein Names

sentrin-specific protease 1

SUMO1/sentrin specific peptidase 1

Recombinant SENP1 Proteins

Cat. No. Product Name Accession Purity
HY-P79459 SENP1 Catalytic Domain Protein, Human (His) Q9P0U3-1 (D415-L644) ≥95%

Related Diseases

Diseases Alias
Chronic Mountain Sickness

Chronic Mountain Sickness, Susceptibility To

Monge Disease

Monge'S Disease
Combat Disorder

Combat Disorders

Combat Neurosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0330 Momordin Ic 99.71% Unkown
HY-N2360 Hinokiflavone 99.80% Unkown
HY-103435 Vialinin A Inhibitor 99.89% Unkown
HY-134594 SENP1-IN-1 Inhibitor 99.81% Unkown
HY-134596 SENP1-IN-3 Inhibitor / Unkown
HY-134595 SENP1-IN-2 Inhibitor / Unkown
HY-134597 SENP1-IN-4 Inhibitor ≥98.0% Unkown
HY-151358 SENP2-IN-1 Inhibitor / Unkown
HY-RS12671 SENP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SENP1 VGNC VGNC:100103
Canis familiaris SENP1 VGNC VGNC:46005
Bos taurus SENP1 VGNC VGNC:34445
Mus musculus SENP1 MGD MGI:2445054
Felis catus SENP1 VGNC VGNC:65002
Rattus norvegicus SENP1 RGD RGD:1310275
Others SENP1 NCBI