ANAPC4 - anaphase promoting complex subunit 4 Gene

Homo sapiens

Also known as APC4

Gene ID: 29945 | Gene type: protein coding

About ANAPC4

Cytogenetic location: 4p15.2 Genomic coordinates (GRCh38): 4:25,377,263-25,418,498 (from NCBI)

This gene has 11 transcripts (splice variants) and 200 orthologues. Ubiquitous expression in endometrium (RPKM 15.3), lymph node (RPKM 11.0) and 25 other tissues.

Summary

A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S Proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

ANAPC4 Products(2)

mRNA	Protein	Name
NM_001286756.2	NP_001273685.1	anaphase-promoting complex subunit 4 isoform 1
NM_013367.3	NP_037499.2	anaphase-promoting complex subunit 4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20360068	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	21241890	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	18485873	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA
involved in protein branched polyubiquitination	IDA IDA: Inferred from direct assay	29033132	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	16364912	GOA
part of anaphase-promoting complex	IPI IPI: Inferred from physical interaction	27120157	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18445686	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC4 Protein Structure

ANAPC4_WD40

ANAPC4

0
200
400
600
808 a.a.

Protein Preferred Names

Protein Names

anaphase-promoting complex subunit 4

cyclosome subunit 4

ANAPC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ANAPC4	Q9UJX5	KIF18A	Homo sapiens	Q8NI77	Anti Bait CoIP	23288039
Intra	ANAPC4	Q9UJX5	KIF18A	Homo sapiens	Q8NI77	Anti Tag CoIP	35271311
Intra	ANAPC4	Q9UJX5	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	25383541
Intra	ANAPC4	Q9UJX5	CDC20	Homo sapiens	Q12834	Anti Bait CoIP	23288039
Intra	ANAPC4	Q9UJX5	CDC20	Homo sapiens	Q12834	Anti Tag CoIP	35271311
Intra	ANAPC4	Q9UJX5	NEK2	Homo sapiens	P51955	Anti Bait CoIP	23288039
Intra	ANAPC4	Q9UJX5	NEK2	Homo sapiens	P51955	Anti Tag CoIP	35271311
Intra	ANAPC4	Q9UJX5	CDC27	Homo sapiens	P30260	Anti Bait CoIP	25383541
Intra	ANAPC4	Q9UJX5	CDC27	Homo sapiens	P30260	Pull Down	26083744
Intra	ANAPC4	Q9UJX5	CDC27	Homo sapiens	P30260	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Brugada Syndrome 9

BRGDA9

Brugada Syndrome, Type 9

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00681	ANAPC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ANAPC4	VGNC	VGNC:25884
Canis familiaris	ANAPC4	VGNC	VGNC:37850
Felis catus	ANAPC4	VGNC	VGNC:107309
Macaca mulatta	ANAPC4	VGNC	VGNC:69642
Rattus norvegicus	ANAPC4	RGD	RGD:1306572
Mus musculus	ANAPC4	MGD	MGI:1098673

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